CAS: 141505-33-1; (R)-N-(4-(4-Methyl-6-Oxo-1,4,5,6-Tetrahydropyridazin-3-yl)Phenyl)Carbonohydrazonoyl Dicyanide

上下游产品

CAS号36725-28-7 6-(4-氨基苯基)-4,5-... | CAS号109-77-3 丙二腈 | CAS号101328-84-1 3(2H)-PYRIDAZIN... | CAS号1260774-44-4 (-)-6-(4-aminop...

6-(4-氨基苯基)-4,5-二氢-5-甲基-3(2H)-哒嗪酮置于盐酸,Sodium Nitrite体系中,用 乙醇,水 用作溶剂,化学反应 1.17H,反应生成左旋西孟旦
参考文献: Process For Preparing Levosimendan And Intermediates For Use In The Process[fr] Procédé Pour La Préparation De Levosimendan Et Intermédiaires Destinés à être Utilisés Dans Le Procédé
标题: Process For Preparing Levosimendan And Intermediates For Use In The Process[fr] Procédé Pour La Préparation De Levosimendan Et Intermédiaires Destinés à être Utilisés Dans Le Procédé
摘要:在一种实施例中,本发明提供了一种制备(-)-6-(4-氨基苯基)-5-甲基吡啶并嗪-3-(2H)-酮的方法,该方法包括:A)将消旋6-(4-氨基苯基)-4,5-二氢-5-甲基-3-(2H)-吡啶并嗪酮(化学式(II))与手性酒石酸衍生物反应,以获得(-)-6-(4-氨基苯基)-4,5-二氢-5-甲基-3-(2H)-吡啶并嗪酮和手性酒石酸衍生物的非对映异构盐;以及b)将非对映异构盐与碱反应,以获得(-)-6-(4-氨基苯基)-4,5-二氢-5-甲基-3-(2H)-吡啶并嗪酮.(-)-6-(4-氨基苯基)-4,5-二氢-5-甲基-3-(2H)-吡啶并嗪酮可用于制备左西咪达.

专利信息

专利号:RU-2118317-C1
优先权日:1991-01-03
标题:(-)-[[4-(1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl)phen- -yl]hydrozono]propanedinitrile and its pharmaceutically acceptable salts, pharmaceutical composition based on thereof, method of synthesis of intermediate compound and method of synthesis of end compound

专利号:TW-201518323-A
优先权日:2013-07-25
标题 :Synthesis of biological conjugates of APELIN polypeptides

专利号:US-12344607-B2
优先权日:2018-10-29
标 题:Substituted 5,6,7,8-tetrahydropyrido[2,3-d]pyrimidine-2,4-diones for treating cardiac diseases
发明人：GRILLO MARK; KANE BRIAN; OSLOB JOHAN; ZHONG MIN; THOMPSON FABIENNE
权利人:MYOKARDIA INC
摘要:The present disclosure provides novel tetrahydropyran (THP)-substituted bicyclic pyrimidinedione compounds, including (6S,7S)-6-fluoro-7-(2-fluoro-5-methylphenyl)-3-(tetrahydro-2H-pyran-4-yl)-5,6,7,8-tetrahydropyrido[2,3-d]pyrimidine-2,4(1H,3H)-dione (shown below), that are useful for the treatment of hypertrophic cardiomyopathy (HCM), conditions associated with left ventricular hypertrophy, conditions associated with diastolic dysfunction, and/or symptoms associated thereof. The synthesis and characterization of the compounds is described, as well as methods for treating HCM and other forms of heart disease.

专利号:US-2014315720-A1
优先权日:2012-10-24
标 题 :Polysaccharide ester microspheres and methods and articles relating thereto
发明人：FALLON DENIS G; GARRETT THOMAS S; KIZER LAWTON E; ZAZZARA KAREN L; COMBS MICHAEL T; JOHNSON RICHARD K; DEHART GARY
权利人:CELANESE ACETATE LLC
摘要:A method for producing a polysaccharide ester microsphere may include forming a polysaccharide ester product from a polysaccharide synthesis, wherein the polysaccharide ester product comprises a polysaccharide ester and a solvent; diluting the polysaccharide ester product, thereby yielding a polysaccharide ester dope; and forming a plurality of polysaccharide ester microspheres from the polysaccharide ester dope. Suitable polysaccharides may include, but are not limited to, starch, cellulose, hemicellulose, algenates, chitosan, and any combination thereof. Esters thereof may be organic esters (e.g., acetate and the like), inorganic esters (e.g., sulfonates and the like), or combinations thereof. Further, the solids conent of the polysaccharide ester dope, in some instances, may be greater than about 16 wt %.

专利号:CN-105439886-A
优先权日:2015-12-24
标 题:Synthesis method of levosimendan drug intermediate p-acetaminophenylethylketone

专利号:CN-119409643-A
优先权日:2024-10-30
标题:Synthesis and refining method of levosimendan