CAS: 1721-26-2; Ethyl 2-Methylnicotinate

相似化合物

56826-61-0 3222-56-8 60032-57-7

上下游产品

ethyl 4-chloro-2-methylpyridine-3-carboxylate Z)-1-amino-ethyliden)-5-oxo-pent-3t-enoic acid ethyl ester2-((Z)-1-amino-ethyliden)-5-oxo-pent-3t-enoic acid ethyl ester 1,3,3-triethoxypropene ethyl amin°Crotonate2-(2,2-diphenyl-vinyl)-nicotinic acid trans-styryl)-nicotinic acid2-(3-nitro-trans-styryl)-nicotinic acid b]pyridin-5-one7-phenyl-7,8-dihydro-pyrano[4,3-b]pyridin-5-one (2-methylpyridin-3-yl)methanol

3-氨基巴豆酸乙酯置于哌啶,Ammonium Cerium(Iv) Nitrate体系中,用 乙醇,丙酮 用作溶剂,化学反应 3.33H,反应生成2-甲基烟酸乙酯
参考文献:非肽血管紧张素ii受体拮抗剂.I.吡啶衍生物的合成和生物活性.
标题:非肽血管紧张素ii受体拮抗剂.I.吡啶衍生物的合成和生物活性.
摘要:取代的吡啶被合成为潜在的血管紧张素ii(aii)受体拮抗剂.在吡啶的2位取代导致有效的活性,并且最佳的烷基长度为四个碳.随着在位置4处引入羟甲基的影响,效力进一步提高.化合物之一是2-丁基-6-氯-4-氯甲基-4-羟甲基-5-甲基-3-[[2'-(1H-四唑-5)-Yl)联苯基-4-Yl]甲基]吡啶9 H(kt3-579)是竞争性aii拮抗剂,Pa2值为9.31,效力是du Pont 753的约10倍.发现它是at1特异性拮抗剂,Ic50为3.09 Nm.
Doi:10.1248/cpb.42.1841

专利信息

专利号:US-9884830-B2
优先权日:2004-05-21
标题 :Synthesis of tetracyclines and analogues thereof
发明人：MYERS ANDREW G; CHAREST MARK G; LERNER CHRISTIAN D; BRUBAKER JASON D; SIEGEL DIONICIO R
权利人:HARVARD COLLEGE
摘要:The tetracycline class of antibiotics has played a major role in the treatment of infectious diseases for the past 50 years. However, the increased use of the tetracyclines in human and veterinary medicine has led to resistance among many organisms previously susceptible to tetracycline antibiotics. The modular synthesis of tetracyclines and tetracycline analogs described provides an efficient and enantioselective route to a variety of tetracycline analogs and polycyclines previously inaccessible via earlier tetracycline syntheses and semi-synthetic methods. These analogs may be used as anti-microbial agents or anti-proliferative agents in the treatment of diseases of humans or other animals.

专利号:US-8486921-B2
优先权日:2006-04-07
标 题:Synthesis of tetracyclines and analogues thereof
发明人：MYERS ANDREW G; BRUBAKER JASON D; SUN CUIXIANG; WANG QIU
权利人:MYERS ANDREW G; BRUBAKER JASON D; SUN CUIXIANG; WANG QIU; HARVARD COLLEGE
摘要:The tetracycline class of antibiotics has played a major role in the treatment of infectious diseases for the past 50 years. However, the increased use of the tetracyclines in human and veterinary medicine has led to resistance among many organisms previously susceptible to tetracycline antibiotics. The modular synthesis of tetracyclines and tetracycline analogs described provides an efficient and enantioselective route to a variety of tetracycline analogs and polycyclines previously inaccessible via earlier tetra-cycline syntheses and semi-synthetic methods. These analogs may be used as anti-microbial agents or anti-pro liferative agents in the treatment of diseases of humans or other animals.

专利号:WO-2024262824-A1
优先权日:2023-06-20
标 题 :Novel process for synthesis of polysubstituted pyridine derivatives
发明人：PARK SEUNG BUM; YI SIHYEONG
权利人:SEOUL NAT UNIV R&DB FOUNDATION
摘要:The present invention relates to a novel method for synthesizing a polysubstituted pyridine derivative and, more specifically, to a method for synthesizing a 2,3,5-substituted pyridine derivative through a specific ring cleavage reaction. In the synthesis method of the present invention, an enamine structure is formed in situ by using beta keto ester/sulfone/phosphonic acid ester and ammonium acetate and subjected to an aldol condensation reaction with 3-formyl (aza) indole/benzofuran, a cyclization reaction, and a ring-cleavage reaction in that order to synthesize a characteristic pyridine structure having an alkyl/aryl substituent attached to the 2-position thereof, an ester/sulfone/phosphonic acid ester attached to the 3-position thereof, and ortho-aminoaryl/phenol including various substituents attached to the 5-position thereof. In particular, (aza)indole/benzofuran and beta keto ester/sulfone/phosphonic acid ester, which are reaction substrates, are substrates having very high accessibility, and enable the introduction of various substituents, thereby constructing a pyridine skeleton having high biocompatibility into which ortho-aminoaryl or phenol substituents having various substituents are introduced.

专利号:US-2018230111-A1
优先权日:2004-05-21
标 题:Synthesis of tetracyclines and analogues thereof

专利号:US-8598148-B2
优先权日:2004-05-21
标题:Synthesis of tetracyclines and analogues thereof

专利号:US-2010130451-A1
优先权日:2006-04-07
标 题:Synthesis of tetracyclines and analogues thereof