CAS: 246047-72-3; (1,3-Bis(2,4,6-Trimethylphenyl)-2-Imidazolidinylidene)Dichloro(Phenylmethylene)(Tricyclohexylphosphine)Ruthenium

上下游产品

Grubbs catalyst first generation 1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazolium chloride 1,3-bis(2,4,6-trimethylphenyl)-2-(trichloromethyl)imidazolidine 1,3-di(2,4,6-trimethylphenyl)-2-(pentafluorophenyl)-2,4,5-trihydroimidazole

专利信息

专利号:US-9809566-B2
优先权日:2012-09-06
标题:Organocatalytic process for asymmetric synthesis of decanolides
发明人：RAWAT VARUN; DEY SOUMEN; SHELKE ANIL MARUTI; SURYAVANSHI GURUNATH MALLAPPA; SUDALAI ARUMUGAM
权利人:COUNCIL SCIENT IND RES
摘要:The present invention discloses organocatalytic process for asymmetric synthesis of highly enantioselective decanolide compounds in high yield with >99% ee. Further, the present invention disclose cost effective, improved organocatalytic process for asymmetric synthesis of highly enantioselective decanolides compounds from non-chiral, cheap, easily available raw materials.

专利号:US-8940923-B2
优先权日:2007-06-13
标题:Method for the synthesis of diacids or diesters from natural fatty acids and/or esters
发明人：DUBOIS JEAN-LUC
权利人:ARKEMA FRANCE
摘要:Disclosed herein a process for the synthesis of diacids or diesters of general formula ROOC—(CH 2 )x-COOR, in which n represents an integer between 5 and 14 and R is either H or an alkyl radical of 1 to 4 carbon atoms, starting from long-chain natural monounsaturated fatty acids or esters comprising at least 10 adjacent carbon atoms per molecule, of formula CH 3 —(CH 2 )n-CHR 1 —CH 2 —CHâ•?CH—(CH 2 )p-COOR, in which R represents H or an alkyl radical comprising from 1 to 4 carbon atoms, R 1 is either H or OH, and n and p, which are identical or different, are indices between 2 and 11.

专利号:US-9150498-B2
优先权日:2011-10-25
标题:Process for the preparation of oseltamivir and methyl 3-epi-shikimate
发明人：RAWAT VARUN; DEY SOUMEN; ARUMUGAM SUDALAI
权利人:COUNCIL SCIENT IND RES
摘要:The present invention discloses high yielding enantioselective process for synthesis of Oseltamivir from readily available starting material, cis-1,4-butene diol. The process features incorporation of chirality using sharpless asymmetric epoxidation (AE) and diastereoselective Barbier allylation and construction of cyclohexene carboxylic acid ester core through a ring closing metathesis (RCM) reaction. Further also disclosed herein is synthesis of (−)-methyl 3-epi-shikimate.

专利号:US-10640482-B2
优先权日:2017-07-21
标题:Synthesis of cannabinoids
发明人：LEAHY JAMES WILLIAM; SHULTZ ZACHARY PAUL; LAWRENCE GRANT ALEXANDER
权利人:UNIV SOUTH FLORIDA
摘要:Provided are synthesis processes and intermediates for preparing cannabinoids and analogs.

专利号:US-8487108-B2
优先权日:2005-11-14
标题 :Piperidinyl carbamate intermediates for the synthesis of aspartic protease inhibitors
发明人：BALDWIN JOHN J; CLAREMON DAVID A; TICE COLIN; CACATIAN SALVACION; DILLARD LAWRENCE W; ISHCHENKO ALEXEY V; YUAN JING; XU ZHENRONG; MCGEEHAN GERARD; SIMPSON ROBERT D; SINGH SURESH B; ZHAO WEI; FLAHERTY PATRICK T
权利人:BALDWIN JOHN J; CLAREMON DAVID A; TICE COLIN; CACATIAN SALVACION; DILLARD LAWRENCE W; ISHCHENKO ALEXEY V; YUAN JING; XU ZHENRONG; MCGEEHAN GERARD; SIMPSON ROBERT D; SINGH SURESH B; ZHAO WEI; FLAHERTY PATRICK T; VITAE PHARMACEUTICALS INC
摘要:The present invention is directed to aspartic protease inhibitors. Certain aspartic protease inhibitors of the invention can be represented by the following structural formula or a pharmaceutically acceptable salt thereof. The present invention is also directed to pharmaceutical compositions comprising the disclosed aspartic protease inhibitors. The present invention is further directed to methods of antagonizing one or more aspartic proteases in a subject in need thereof, and methods for treating an aspartic protease mediated disorder in a subject using the disclosed aspartic protease inhibitors.

专利号:US-12049443-B2
优先权日:2018-12-10
标题 :Synthesis of conjugated diene pheromones and related compounds
发明人：WAMPLER KEITH M; LEE CHOON WOO; ROZZELL DAVID
权利人:PROVIVI INC
摘要:Methods for preparing conjugated dienes are described. An α,β-unsaturated E olefin intermediate may be prepared via cross-metathesis using a catalyst comprising a transition metal (e.g., ruthenium), a first carbene ligand (e.g., a substituted indenylidene) and an N-heterocyclic carbene ligand (e.g., an imidazolidinylidene). The catalyst further includes a phenylphosphine ligand, a tri(isopropoxy)phosphine ligand, a dimethylsulfoxide ligand, an acetonitrile ligand, or a pyridine ligand. Following the cross metathesis-step, the α,β-unsaturated aldehyde intermediate may be converted to the conjugated diene product via reaction with a phosphonium ylide. Products obtained via the methods of the disclosure include (7E,9Z)-dodeca-7,9-dien-1-yl acetate, a pheromone produced by Lobesia botrana (European grapevine moth), and other insect pheromones.