CAS: 287944-16-5; 3,6-Dihydro-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-yl)-2H-Pyran

相似化合物

1002127-60-7 2244092-89-3 2304685-56-9

上下游产品

2-(3-Allyloxy-1-Methylene-Propyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane 1295521-64-0

4-(Prop-2-En-1-Yloxy)But-1-Yne置于rucl2(1,3-Dimesityl-Imidazolidin-2-yl)(Pcy3)(=chph) Potassium Acetate,Copper(L) Chloride,Lithium Chloride体系中,用 二氯甲烷,N,N-二甲基甲酰胺 用作溶剂,化学反应 16.0H,反应生成3,6-二氢-2H-吡喃-4-硼酸频哪醇酯
参考文献: Akt Inhibitors[fr] Inhibiteurs D'Akt
标题: Akt Inhibitors[fr] Inhibiteurs D'Akt
摘要:本发明提供了公式为:Formula I的akt抑制剂.本发明还提供了包含formula I化合物的药物组合物,Formula I化合物的用途以及使用formula I化合物的方法.

专利信息

专利号:US-12384788-B2
优先权日:2019-09-13
标 题 :1,4-dihydrobenzo[d]pyrazolo[3,4-f][1,3]diazepine derivatives and related compounds as LRRK2, NUAK1 and/or TYK2 kinase modulators for the treatment of e.g. autoimmune disease
发明人：KOESTLER ROLAND; TASSEL JEAN; THORMANN MICHAEL; YEHIA NASSER; TREML ANDREAS; ALMSTETTER MICHAEL
权利人:ORIGENIS GMBH
摘要:The present invention relates to compounds of formula (I) that are capable of modulating, e.g., inhibiting or activating, one or more kinases, especially LRRK2 and/or NUAK1 and/or TYK2 or mutants thereof. The compounds are useful for treating diseases, such as autoimmune diseases, inflammatory diseases, bone diseases, metabolic diseases, neurological and neurodegenerative diseases, cancer, cardiovascular diseases, allergies, asthma, Alzheimer's disease, Parkinson's disease, skin disorders, eye diseases, infectious diseases and hormone-related diseases. The present description discloses the synthesis and characterisation of exemplary compounds as well as pharmacological data thereof (e.g. pages 40 to 146; examples 1 to 63; compounds 1 to 248; tables 1 to 3). Preferred compounds are e.g. 1,4-dihydrobenzo[d]pyrazolo[3,4-f][1,3]diazepine derivatives and related compounds. An exemplary compound is e.g. 5-(2,6-difluorophenyl)-8-methoxy-1,4-dihydrobenzo[d]pyrazolo[3,4-f][1,3]diazepine (example 49). (Formula (II):

专利号:US-2021085684-A1
优先权日:2016-07-06
标 题:Pde9 inhibitors for treatment of peripheral diseases
发明人：SVENSTRUP NIELS; PARACHIKOVA ANNA I; MCARTHUR JAMES
权利人:IMARA INC
摘要:The present invention relates to PDE9 inhibitors, their synthesis, and their use for treatment of benign prostate hyperplasia, beta thalassemia, and sickle cell disease.

专利号:CN-115785096-A
优先权日:2022-11-22
标 题:Method for highly selective synthesis of pyrazolone spirodihydroquinoline or pyrazolone spiroindoline compound

专利号:CN-115785096-B
优先权日:2022-11-22
标 题 :Method for highly selective synthesis of pyrazolone spirodihydroquinoline or pyrazolone spiroindoline compounds

专利号:US-2025026766-A1
优先权日:2022-01-12
标题 :Thiazolopyridyl Amide Derivatives as DNA Polymerase Theta Inhibitors
发明人：LI JING; XU WENQING; WANG ZHIWEI
权利人:BEIGENE LTD
摘要:The present invention relates to compounds containing thiazolopyridyl amide structure, the process for their synthesis, as well as the use of such compounds for inhibiting DNA Polymerase Theta (Pol Theta), and in the treatment of various diseases including cancers.