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专利信息

专利号:WO-9421230-A1
优先权日:1993-03-19
标题 :Method and compositions for disrupting the epithelial barrier function
发明人：ELIAS PETER M; THORNFELDT CARL R; GRAYSON STEPHEN
权利人:CELLEGY PHARMA INC; UNIV CALIFORNIA; ELIAS PETER M; THORNFELDT CARL R; GRAYSON STEPHEN
摘要:A method for disrupting epithelial barrier function in a host in need of the topical administration of a physiologically active substance which comprises applying to the epithelium of the host, barrier-disrupting amount of at least one agent selected from the group consisting of an inhibitor of ceramide synthesis, inhibitor of acylceramide synthesis, inhibitor of glucosylceramide synthesis, and inhibitor of sphingomyelin synthesis, an inhibitor of fatty acid synthesis, an inhibitor of cholesterol synthesis, a degradation enzyme of ceramides, acylceramide, glucosylceramides, sphingomyelin, an inhibitor of phospholipid, glycosphingolipid, including glucosylceramide, acylceramide or sphingomyelin degradation, and both inhibitors and stimulators of metabolic enzymes of free fatty acids, ceramide, and cholesterol, as well as a topical composition useful therefor are disclosed.

专利号:WO-9817253-A1
优先权日:1996-10-23
标 题 :Method and compositions for disrupting the epithelial barrier function
发明人：ELIAS PETER M; FEINGOLD KENNETH R; HOLLERAN WALTER M; THORNFELDT CARL R
权利人:UNIV CALIFORNIA; CELLEGY PHARMA INC
摘要:A method for disrupting epithelial barrier function in a host in need of the topical administration of a physiologically active substance which comprises applying to the epithelium of the host, barrier-disrupting amount of at least one agent selected from the group consisting of an inhibitor of ceramide synthesis, inhibitor of acylceramide synthesis, inhibitor of glucosylceramide synthesis, and inhibitor of sphingomyelin synthesis, an inhibitor of fatty acid synthesis, an inhibitor of cholesterol synthesis, a degradation enzyme of ceramides, acylceramide, glucosylceramides, sphingomyelin, an inhibitor of phospholipid, glycosphingolipid, including glucosylceramide, acylceramide or sphingomyelin degradation, and both inhibitors and stimulators of metabolic enzymes of free fatty acids, ceramide, and cholesterol, as well as a topical composition useful therefor are disclosed.

专利号:US-6562606-B1
优先权日:1993-03-19
标 题:Methods and compositions for disrupting the epithelial barrier function
发明人：ELIAS PETER M; FEINGOLD KENNETH R; HOLLERAN WALTER M
权利人:UNIV CALIFORNIA; CELLEGY PHARMA INC
摘要:A method for disrupting epithelial barrier function in a host in need of the topical administration of a physiologically active substance which comprises applying to the epithelium of the host, barrier-disrupting amount of at least one agent selected from the group consisting of an inhibitor of ceramide synthesis, inhibitor of acylceramide synthesis, inhibitor of glucosylceramide synthesis, and inhibitor of sphingomyelin synthesis, an inhibitor of fatty acid synthesis, an inhibitor of cholesterol synthesis, a degradation enzyme of ceramides, acylceramide, glucosylceramides, sphingomyelin, an inhibitor of phospholipid, glycosphingolipid, including glucosylceramide, acylceramide or sphingomyelin degradation, and both inhibitors and stimulators of metabolic enzymes of free fatty acids, ceramide, and cholesterol, as well as a topical composition useful therefor are disclosed.