CAS: 622-59-3; P-Tolylisothiocyanate

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CAS号75-15-0 二硫化碳 | CAS号106-49-0 对甲苯胺 | CAS号43009-17-2 p-tolyldithi°Ca... | CAS号463-71-8 硫光气 | CAS号7175-47-5 4-甲苯基异腈 | CAS号1005-56-7 氯化硫代甲酸苯酯 | CAS号22517-50-6 O-phenyl N-(4-m... | CAS号13037-22-4 N-(4-methylphen... | CAS号97-65-4 衣康酸 | CAS号333-20-0 硫氰酸钾 | CAS号109322-22-7 3-[(2-chloroind... | CAS号109322-12-5 1-[[2-(2-chloro... | CAS号3507-26-4 2-氯-6-甲基苯并噻唑 | CAS号14185-56-9 N-[(4-methylphe... | CAS号141300-18-7 5-amino-6-(4-me... | CAS号141300-28-9 brn 4878225 | CAS号20369-61-3 2,3,4,6-四-o-乙酰基... | CAS号22814-94-4 Hydrazinecarbot... | CAS号20950-37-2 1-(4-methylphen... | CAS号2209-25-8 1,2-Hydrazinedi...

4-甲苯基异腈置于selenium,Sulfur,三乙胺体系中,用 四氢呋喃 作为反应溶剂,化学反应 1.0H,以90%的收率获得产物对甲苯异硫氰酸酯
参考文献:新型硒催化异氰酸酯和元素硫合成异硫氰酸酯
标题:新型硒催化异氰酸酯和元素硫合成异硫氰酸酯
摘要:通过催化量的元素硒,在温和的条件下,由相应的异氰化物和元素硫以非常好至极佳的收率合成了各种脂肪族和芳香族异硫氰酸酯.
DOI:10.1016/0040-4039(91)80817-P

专利信息

专利号:US-5635157-A
优先权日:1992-04-13
标 题 :Synthesis of 4-substituted-trans-1,2-diaminocyclohexyl polyaminocarboxylate metal chelating agents for the preparation of stable radiometal antibody immunoconjugates for therapy and spect and pet imaging
发明人：MEASE RONNIE C; KOLSKY KATHRYN L; MAUSNER LEONARD F; SRIVASTAVA SURESH C
摘要:Cyclohexyl chelating agents useful in forming antibody-metal conjugates useful for diagnostic and therapeutic purposes. New compounds and processes of forming these compounds are disclosed including 4-haloacetamido-trans-1,2-diaminocyclohexyl polyaminocarboxylate and 4-isothiocyanato-trans-1,2-diamino cyclohexane-N, N, N', N'-tetra acetic acid.

专利号:US-5585487-A
优先权日:1995-05-26
标题:Method for the preparation of β-thiolactam compound
发明人：OISHI AKIHIRO; TAGUCHI YOICHI; SHIBUYA ISAO; TSUCHIYA TOHRU
权利人:AGENCY IND SCIENCE TECHN
摘要:Disclosed is a method for the preparation of a beta -thiolactam compound, i.e. a 7-substituted-2-oxa-7-azabicyclo [3.2.0]-heptan-6-thione, represented by the general formula in which R is an alkyl or aryl group, having usefulness as an intermediate for the synthesis of various biologically active compounds. The compound can be prepared by the reaction of an isothiocyanate compound R-NCS, R being the same as above, and 2,3-dihydrofuran, preferably, under pressurization up to 2000 atmospheres or higher at an elevated temperature.

专利号:US-7147856-B2
优先权日:1996-08-28
标题 :Stable radioiodine conjugates and methods of their synthesis
发明人：GOVINDAN SERENGULAM V
权利人:IMMUNOMEDICS INC
摘要:Methods are described for conjugating radioiodinated peptides or carbohydrate structures to proteins with improved yields and qualities of conjugates. In one method, specially designed radioiodinated bifunctional peptides containing nonmetabolizable amide bonds are coupled to antibodies. In a second method, radioiodinated nonmetabolizable bifunctional peptides, which also contain aminopolycarboxylates, are coupled to antibodies. In a third method, radioiodinated bifunctional aminopolycarboxylates are coupled to antibodies. In a fourth method, a hydrazide-appended antibody is coupled to a radioiodinated carbohydrate or a thiolated antibody is coupled to a hydrazide-appended and radioiodinated carbohydrate. In a fifth method a monoderivatized cyanuric chloride is used to conjugate thiolated antibody. Radioiodinated residualizing antibody conjugates made by these methods are particularly stable in vivo and are suitable for radioimmunodetection and radioimmunotherapy.

专利号:US-6663866-B1
优先权日:1996-08-28
标题:Stable radioiodine conjugates and methods for their synthesis
发明人：GOVINDAN SERENGULAM V
权利人:IMMUNOMEDICS INC
摘要:Methods are described for conjugating radioiodinated peptides to non-metabolizable carbohydrates with improved yields and qualities of conjugates. Radioiodinated residualizing antibody conjugates comprising a carbohydrate-appended peptide are also provided. The instant radioiodinated residualizing antibody conjugates are particularly stable in vivo and are suitable for radioimmunodetection and radioimmunotherapy.

专利号:US-5292938-A
优先权日:1992-04-13
标题 :Synthesis of 4-substituted-trans-1, 2-diaminocyclohexyl polyaminocarboxylate metal chelating agents for the preparation of stable radiometal antibody immunoconjugates for therapy and spect and pet imaging

专利号:DD-294021-A5
优先权日:1990-05-02
标题 :PROCESS FOR SYNTHESIS OF 1- (4,7-DIMETHYL-2-OXO-2H-CHROMEN-6-YLOXYACETYL) -4-SUBSTITUTED -THIOSEMICARBAZIDES