CAS: 6705-33-5; Pyrazin-2-Ylmethanol

该化合物是一种有机化合物,其特点是其配有双子环结构,这是一个由六人组成的芳香环,在非对称位置上含有两个氮原子;该化合物具有配附于环的氢氧甲基组(-CH2OH),有助于其反应性和潜在应用;它一般是无色的,可粉黄的黄色液体或固体,视其纯度和形态而定;2-Pyrazinemirmoal在水和各种有机溶剂中溶解,可使其适应不同的化学反应;其特性包括中极性,以及由于氢氧化甲基组而参与氢联结的能力;该化合物由于具有潜在的生物活动,并作为有机合成的建筑块,因此对各个领域,包括制药和农用化学物感兴趣;在处理和储存时,应参考安全数据,如任何化学物质,以确保采取适当的预防措施.

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98-97-5 6924-68-1 5780-66-5

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ECHA物质C&L通报

上下游产品

ethylenediamine glycerol pyrazinecarboxaldehyde 4-{[(2-pyrazinyl)methyl]sulfanyl}aniline 7-{4-[2-(butoxy)ethoxy]phenyl}-1-isobutyl-N-({4-[(2-pyrazinyl)methyl]sulfanyl}phenyl)-2,3-dihydro-1H-1-benzazepine-4-carboxamide [6-(pyrazin-2-ylmethoxy)-pyridin-3-yl]-carbamic acid phenyl ester

合成工艺路线路线简述

    2-甲基吡嗪置于sodium Hydroxide,双氧水,溶剂黄146体系中,化学反应生成 2-羟甲基吡嗪
    参考文献:Some Diazine-N-Oxides1
    标题:Some Diazine-N-Oxides1
    摘要:
    DOI:10.1021/jo01105A003

    海关参考信息

    专利信息


    专利号:US-2011319644-A1
    优先权日:2006-11-02
    标 题:Process for production of 1-hydroxy-19-norcyclovitamin d derivative and intermediate for the production
    发明人:TOYODA ASAKO; NAGAI HAZUKI; KONUKI KANAME; TSUCHIDA TOSHIO
    权利人:TOYODA ASAKO; NAGAI HAZUKI; KONUKI KANAME; TSUCHIDA TOSHIO
    摘要:A cyclovitamin D derivative produced from 25-hydroxyvitamin D is reacted with osmium tetraoxide or a permanganic acid salt to produce a 10,19-diolcyclovitamin D derivative. The 10,19-diolcyclovitamin D derivative is reacted with a perhalogenic acid salt or lead tetraacetate to produce a 10-oxocyclovitamin D derivative. A 1-hydroxycyclovitamin D derivative is produced from the 10-oxocyclovitamin D derivative via a cyclovitamin D derivative and a 1,10-olefincyclovitamin D derivative. The 1-hydrocyclovitamin D derivative is subjected to solvolysis, thereby producing a 1-hydroxy-19-norviatmin D derivative. Thus provided are a novel process for production of 1-hydroxy-19-norcyclovitamin D derivative that is utilizable as an intermediate in the synthesis of 1-hydroxy-19-norvitamin D derivative which is useful as a pharmaceutical agent; and an intermediate for the production.

    专利号:WO-2014093723-A2
    优先权日:2012-12-12
    标 题 :Group-assistant-purification (gap) synthesis of velcade, dimeric analogs, and amino compounds
    发明人:LI GUIGEN
    权利人:NANJING UNIVERSITY OF TECHNOLOGY

    专利号:US-3113132-A
    优先权日:1961-03-17
    标 题:Synthesis of chlorinated alkylpyrazines
    发明人:BAXTER GEORGE E; LEVIS JR WILLIAM W
    权利人:WYANDOTTE CHEMICALS CORP

    专利号:US-2008176865-A1
    优先权日:2005-06-15
    标 题:Substituted arylpyrazoles
    发明人:BILLEN DENIS; BOYLE JESSICA; CRITCHER DOUGLAS JAMES; GETHIN DAVID MORRIS; HALL KIM THOMAS; KYNE GRAHAM MICHAEL
    权利人:PFIZER LTD
    摘要:This invention relates to a range of 1-aryl-4-cyclopropylpyrazoles in which the cyclopropyl ring is substituted at the angular position, and pharmaceutically acceptable salts and solvates thereof, to compositions comprising such compounds, processes to their synthesis and their use as parasiticides.

    专利号:CN-107827827-A
    优先权日:2017-12-13
    标题:A kind of synthesis technique of 2,5-dimethylol-3,6-dimethylpyrazine

    专利号:US-7968584-B2
    优先权日:2005-06-15
    标 题:Substituted arylpyrazoles
    发明人:BILLEN DENIS; BOYLE JESSICA; CRITCHER DOUGLAS JAMES; GETHIN DAVID MORRIS; HALL KIM THOMAS; KYNE GRAHAM MICHAEL
    权利人:PFIZER; PFIZER PROD INC
    摘要:This invention relates to a range of 1-aryl-4-cyclopropylpyrazoles in which the cyclopropyl ring is substituted at the angular position, and pharmaceutically acceptable salts and solvates thereof, to compositions comprising such compounds, processes to their synthesis and their use as parasiticides.
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    合成参考文献


    摘要:Toxicology and Applied Pharmacology., 17(244), 1970 []
    参考文献:10.1007/s10886-021-01324-4
    摘要:Bohman B, Tan MMY, Flematti GR, Peakall R. Drakolide Structure-activity Relationships for Sexual Attraction of Zeleboria Wasp Pollinator. Journal of Chemical Ecology. 2022 Jan 31;48(3):323–36. doi: 10.1007/s10886-021-01324-4.
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