CAS: 79-33-4; (S)-2-Hydroxypropanoic Acid

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CAS号56-41-7 L-丙氨酸 | CAS号53651-69-7 乳酸丙酯 | CAS号687-47-8 (-)-乳酸乙酯 | CAS号27871-49-4 L-乳酸甲酯 | CAS号50-99-7 D(+)-无水葡萄糖 | CAS号127-17-3 丙酮酸 | CAS号113-24-6 丙酮酸钠 | CAS号530-26-7 D-甘露糖 | CAS号138-08-9 磷烯醇丙酮酸 | CAS号36394-75-9 (S)-(-)-2-乙酰氧基丙酰氯 | CAS号4254-15-3 (S)-1,2-丙二醇 | CAS号13076-19-2 (3R,6S)-3,6-Dim... | CAS号13076-17-0 D-丙交酯 | CAS号4511-42-6 L-丙交酯 | CAS号192316-22-6 (alphas)-(9ci)-... | CAS号127-17-3 丙酮酸 | CAS号34451-19-9 L－乳酸正丁酯 | CAS号71-23-8 正丙醇 | CAS号57-55-6 丙二醇

葡萄糖 反应生成 L-乳酸
参考文献:An Analysis Of Skin Perfusion Over The Achilles Tendon In Varying Degrees Of Plantarflexion
标题:An Analysis Of Skin Perfusion Over The Achilles Tendon In Varying Degrees Of Plantarflexion
摘要:开放性跟腱修复术后延迟伤口愈合和较少见的伤口破裂是重要的并发症.当踝关节背屈时,跟腱上的皮肤灌注可能会减少.本研究旨在分析20名志愿者在不同程度背屈踝关节时跟腱上的皮肤灌注情况. 皮肤灌注通过使用novametrix Tco2M 860监测器测量经皮皮肤氧压(tcpo2)来确定.在20名志愿者的跟腱内侧边缘进行测量.当踝关节背屈至20°时,皮肤灌注最大.超过这个角度后,皮肤灌注减少.在40°背屈时,皮肤灌注减少了高达49%(平均35%,范围27%至49%).我们得出结论,超过20°的背屈会减少跟腱区域的皮肤灌注.尽管这项研究是在未手术病例上进行的,因此受限,但这些发现可能对跟腱修复术后石膏固定位置具有临床意义.
DOI:10.1177/107110070102200707

专利信息

专利号:WO-2020253243-A1
优先权日:2019-06-20
标题:Process method for catalyzed synthesis of lactide with alkali metal compound
发明人：JIANG WEI; ZHANG YANKAI; SUN PING; LI AIMIN; CHEN JINLONG; ZHANG QUANXING
权利人:NANJING UNIVERSITY OF TECHNOLOGY; NANJING QUANKAI RES INSTITUTE OF BIOMATERIALS CO LTD
摘要:The present invention provides a process method for catalyzed synthesis of lactide with an alkali metal compound, comprising: mixing an alkali metal compound with a lactic acid oligomer, and carrying out a cracking reaction to obtain lactide by means of vacuum distillation, wherein the alkali metal compound used is one or a plurality of an alkali metal carbonate, an alkali metal bicarbonate, and an alkali metal hydroxide. Compared with the prior art, the advantages of the present invention is that the alkali metal compound reacts and dissolves quickly after being added to the system avoiding the problem of pipeline blocking due to a catalyst not dissolving, the alkali metal compound used is cheap and readily available, the amount of the catalyst used is small, the yield of the reaction product lactide is greater than 80%, and the reaction is rapid and easy to industrialize.

专利号:WO-2020253244-A1
优先权日:2019-06-20
标 题 :Process for catalytic synthesis of lactide
发明人：JIANG WEI; ZHANG YANKAI; SUN PING; LI AIMIN; ZHANG QUANXING
权利人:NANJING UNIVERSITY OF TECHNOLOGY; NANJING QUANKAI RES INSTITUTE OF BIOMATERIALS CO LTD
摘要:The present invention provides a process for the catalytic synthesis of lactide, comprising: mixing a lactic acid oligomer with a composite catalyst; and synthesizing lactide under a heating condition, and collecting the product using a vacuum distillation mode. The used composite catalyst is composed of a zinc or tin compound and an alkali metal compound. Compared with the prior art, the advantages of the present invention are that: the used composite catalyst features a high production rate with a small use amount, a low reaction temperature (150-220°C), and a short reaction time (2-5 h), has a single pass yield that may reach 95% or more, reduces energy consumption compared with the prior art, and facilitates industrial implementations.

专利号:US-11987567-B2
优先权日:2021-09-15
标题 :Synthesis method of lactide by confinement effect catalysis of crystalline porous polymer material
发明人：ZHAO YINGJIE; QIU WENQI; LIU HUI; ZHANG ZHENXIU; ZHAO JINYU
权利人:QINGDAO UNIV OF SCIENCE AND TECHNOLOGY
摘要:The present invention discloses a synthesis method of lactide by confinement effect catalysis of crystalline porous polymer material, wherein the method comprising: (I) synthesis of catalyst; (II) synthesis of lactide by confinement effect catalysis; and (III) purification of lactide. In the present invention, a yield of L-lactide by catalysis of L-lactic acid by crystalline polymers is as high as 85.6%, which is 10% higher than the yield of lactide by H-β molecular sieve reported in documents currently available; it is easy to prepare the crystalline porous polymer material catalyst, which is environmental friendly, has a high yield and is recyclable, for consecutive 7 times the catalysis yield is maintained to be higher than 70%, and catalysis yield conservation rate is far higher than catalysis effects of catalysts reported in documents currently available.

专利号:US-12240835-B2
优先权日:2018-09-18
标题:Substituted benzamides as intermediates in the synthesis of inhibitors of tyrosine kinase enzymatic activity
发明人：ROMERO F ANTHONY; KIRSCHBERG THORSTEN A; HALCOMB RANDALL; XU YINGZI
权利人:TERNS PHARMACEUTICALS INC
摘要:Provided herein are compounds, preferably compounds inhibiting tyrosine kinase enzymatic activity of a protein selected from Abelson protein (ABL1), Abelson-related protein (ABL2), or a chimeric protein BCR-ABL1, compositions thereof, and methods of their preparation, and methods of inhibiting tyrosine kinase enzymatic activity of a protein selected from Abelson protein (ABL1), Abelson-related protein (ABL2), or a chimeric protein BCR-ABL1, and methods for treating diseases wherein modulation of BCR-ABL1 activity prevents, inhibits, or ameliorates the pathology and/or symptomology of the disease. Intermediates such as compounds of Formula (S23), which are useful in the synthesis of compounds inhibiting tyrosine kinase enzymatic activity of a protein selected from Abelson protein (ABL1), Abelson-related protein (ABL2), or a chimeric protein BCR-ABL1, are also provided.

专利号:WO-2023282864-A1
优先权日:2021-07-09
标 题:Synthesis of poly(lactic acid) catalyzed by nanoparticle metal
发明人：ÇAT MURAT
权利人:MD POLIMER GIDA SANAYI TICARET LTD SIRKETI
摘要:The invention relates to the synthesis of polylactic acid catalyzed by nanoparticle 5 metal, wherein, by use of metal powder in the size of nanoparticles, it enables not only increasing reaction efficiency but also easily removing metal powder from the reaction medium when the reaction is completed, without the need for depolymerization, and it prevents the primary reaction product from undergoing external processes, reduces the total reaction processing time and the number of 0 reactors, units employed in the reaction, and allows obtaining high molecular weight product.

专利号:US-4190579-A
优先权日:1977-12-29
标题:Synthesis of beta-lactams from azetidine carboxylic acid esters
发明人：LIPSHUTZ BRUCE H; WASSERMAN HARRY H; WU JAMES S
权利人:RESEARCH CORP
摘要:Azetidine carboxylic acid esters are converted into enol silyl ethers which, as enamino ketene acetals, undergo ready oxidative cleavage of the ethylenically unsaturated double bond, e.g. by dye-sensitized photo-oxygenation, to form beta-lactams. The beta-lactams and substitution products thereof are useful intermediates in the synthesis of biologically active lactams.