CAS: 866783-13-3; (1S)-4,5-Dimethoxy-1-[(Methylamino)Methyl]Benzocyclobutane Hydrochloride

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CAS号866783-12-2 (S)-(4,5-dimeth... | CAS号35202-54-1 4,5-二甲氧基-1-氰基苯并环丁烷 | CAS号41234-23-5 4,5-二甲氧基苯并环丁烷-1-甲酸 | CAS号35249-62-8 2-溴-4,5-二甲氧基苯丙腈 | CAS号1346558-07-3 (S)-3,4-dimetho... | CAS号155974-00-8 伊伐雷定 | CAS号148849-67-6 盐酸伊伐布雷定 | CAS号1086026-31-4 3-[3-[[[(7S)-3,...

4,5-二甲氧基-1-(氨基甲基)苯并环丁烷置于三氟化硼四氢呋喃络合物,溶剂黄146,N,N'-羰基二咪唑,Sodium Hydroxide体系中,用 四氢呋喃,乙醇,二氯甲烷,醋酸异丙酯,水 作为反应溶剂,化学反应 23.75H,反应生成 (1S)-4,5-二甲氧基-1-[(甲基氨基)甲基]苯并环丁烷盐酸盐
参考文献:(1S)-4,5-二甲氧基-1-[(甲基氨基)甲基]苯 并环丁烷盐酸盐的制备方法
标题:(1S)-4,5-二甲氧基-1-[(甲基氨基)甲基]苯 并环丁烷盐酸盐的制备方法
摘要:本发明提供了一种(1S)‑4,5‑二甲氧基‑1‑[(甲基氨基)甲基]苯并环丁烷盐酸盐的制备方法,具体地,所述的方法通过用在惰性溶剂中,用4,5‑二甲氧基苯并环丁烷‑1‑甲基甲酰胺,经还原,盐析的合成路线,最后得到(1S)‑4,5‑二甲氧基‑1‑[(甲基氨基)甲基]苯并环丁烷盐酸盐(I).该反应具有操作简单,反应条件温和,原辅料洁净易得,总体成本低以及化学和对映异构体纯度高等优点,因此适合工业化生产.

专利信息

专利号:US-6982350-B2
优先权日:2004-05-19
标 题:Process for the synthesis of (1S)-4,5-dimethoxy-1-(methylaminomethyl)-benzocyclobutane and addition salts thereof, and to the application thereof in the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid
发明人：LERESTIF JEAN-MICHEL; GONZALEZ BLANCO ISAAC; LECOUVE JEAN-PIERRE; BRIGOT DANIEL
权利人:SERVIER LAB
摘要:Process for the synthesis of the compound of formula (I): n n Application in the synthesis of ivabradine, addition salts thereof with a pharmaceutically acceptable acid, and hydrates thereof.

专利号:US-8101747-B2
优先权日:2009-03-31
标 题:Process for the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid
发明人：PEGLION JEAN-LOUIS; DESSINGES AIMEE; SERKIZ BERNARD
权利人:PEGLION JEAN-LOUIS; DESSINGES AIMEE; SERKIZ BERNARD; SERVIER LAB
摘要:Process for the synthesis of ivabradine of formula (I): n nand addition salts thereof with a pharmaceutically acceptable acid.

专利号:US-8835627-B2
优先权日:2012-03-27
标 题 :Process for the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid
发明人：LE FLOHIC ALEXANDRE; GRANDJEAN MATHIEU
权利人:SERVIER LAB
摘要:Process for the synthesis of ivabradine of formula (I): n nand addition salts thereof with a pharmaceutically acceptable acid.

专利号:BR-PI0500480-B1
优先权日:2004-05-19
标 题 :PROCESS FOR THE SYNTHESIS OF IVABRADINE AS WELL AS PROCESSES FOR THE RESOLUTION OF AMINE AND FOR THE SYNTHESIS OF COMPOUND RELATED TO THE SYNTHESIS OF IVABRADINE

专利号:US-2005261376-A1
优先权日:2004-05-19
标 题:Process for the synthesis of (is)-4,5-dimethoxy-1-(methylaminomethyl)-benzocyclobutane and addition salts thereof, and to the application thereof in the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid

专利号:FR-2986804-A1
优先权日:2012-02-09
标题 :PROCESS FOR THE ENZYMATIC SYNTHESIS OF (7S) 3,4-DIMETHOXYBICYCLO [4.2.0] OCTA-1,3,5-TRIENE 7-CARBOXYLIC ACID OR ITS ESTERS, AND APPLICATION TO THE SYNTHESIS OF IVABRADIN AND IES SALTS