CAS: 1255942-06-3; 3-Amino-1-(11,12-Didehydrodibenz[b,F]Azocin-5(6H)-yl)-1-Propanone

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参考文献:一种基于click反应的car-T细胞药物递送平台及其构建方法与应用
标题:一种基于click反应的car-T细胞药物递送平台及其构建方法与应用
摘要:本发明公开了一种基于click反应的car‑t细胞药物递送平台及其构建方法与应用,其是由负载药物的烯/炔基工具分子和表达至car‑t细胞表面的叠氮基寡糖发生click反应形成.本发明优点包括:以car‑t细胞为基础,通过click反应键合载药纳米颗粒与car‑t细胞,构建一种新的药物递送平台,增强药物疗效,减少了药物的毒副作用,为car‑t细胞在药物递送平台领域的应用提供了理论和实践基础.

专利信息

专利号:US-2022411860-A1
优先权日:2015-09-28
标题:Design and synthesis of novel disulfide linker based nucleotides as reversible terminators for dna sequencing by synthesis

专利号:US-2023160000-A1
优先权日:2015-09-28
标 题:Synthesis of novel disulfide linker based nucleotides as reversible terminators for dna sequencing by synthesis

专利号:US-12018097-B2
优先权日:2017-06-09
标题 :Non-chromatographic purification of macrocyclic peptides by a resin catch and release
发明人：CREECH GARDNER S; KHEIRABADI MAHBOUBEH; EASTGATE MARTIN D; NIRSCHL DAVID S; CARTER PERCY H
权利人:BRISTOL MYERS SQUIBB CO
摘要:The disclosure is directed to the synthesis and improved methods for purifying macrocyclic peptides produced by solid phase peptide synthesis. The synthesized peptide is capped with an alkyne-functionalized or azide-functionalized compound of formula (I):prior to cleavage of the peptide from the solid phase support.

专利号:US-2023028388-A1
优先权日:2015-09-28
标 题 :Design and synthesis of novel disulfide linker based nucleotides as reversible terminators for dna sequencing by synthesis

专利号:US-2022401561-A1
优先权日:2019-09-30
标题 :Protein-macromolecule conjugates and methods of use thereof
发明人：SONG YUNTAO; LI HUI; ZHOU HAIPING; LIAO CHUAN
权利人:BEIJING XUANYI PHARMASCIENCES CO LTD
摘要:The present disclosure provides protein-macromolecule conjugates, releasable linkers, and macromolecules, as defined herein. The disclosed conjugates provide unique properties that ae based at least upon the properties of linker and number of linker-Macromolecule moieties. Also provided herein are a method of synthesis and use of conjugates in treating diseases and disorders.

专利号:US-11725224-B2
优先权日:2018-04-16
标题 :Methods for co-activating in vitro non-standard amino acid (nsAA) incorporation and glycosylation in crude cell lysates
发明人：JEWETT MICHAEL CHRISTOPHER; STARK JESSICA CAROL; HERSHEWE JASMINE
权利人:UNIV NORTHWESTERN
摘要:Disclosed are methods, systems, components, and compositions for cell-free synthesis of proteins and glycoproteins. The methods, systems, components, and compositions may be utilized for incorporating non-standard amino acids (nsAAs) into cell-free synthesized proteins and glycosylating or otherwise modifying the cell-free synthesized proteins in vitro. The nsAAs of the cell-free synthesized protein may be modified via glycosylation or other modification.