CAS: 20098-48-0; 1,2,3-Trichloro-5-Nitrobenzene

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CAS号99-30-9 2,6-二氯-4-硝基苯胺 | CAS号87-61-6 1,2,3-三氯苯 | CAS号99-54-7 1,2-二氯-4-硝基苯 | CAS号7647-18-9 氯化锑(V) | CAS号3107-19-5 3,5-二氯-4-氟硝基苯 | CAS号2729-34-2 3,5-二氯-4-氟苯胺 | CAS号618-80-4 2,6-二氯-4-硝基苯酚 | CAS号634-91-3 3,4,5-三氯苯胺 | CAS号315224-26-1 2,4-二氯-N-[3,5-二... | CAS号17742-69-7 2,6-二氯-4-硝基苯甲醚 | CAS号88135-30-2 2,6-Dichloro-4-... | CAS号58291-70-6 1-(2,6-dichloro... | CAS号58291-91-1 3,5-dichloro-4-... | CAS号599-52-0 HEXACHLORO-2,5-...

三氯苯置于(1,5-Cyclooctadiene)(Methoxy)Iridium(I) Dimer,Copper Diacetate,三乙胺,4,4'-二叔丁基-2,2'-二吡啶,Sodium Nitrite体系中,用 四氢呋喃,乙腈 用作溶剂,化学反应 36.03H,反应生成1,2,3-三氯-5-硝基苯
参考文献:带有芳基化的芳烃的邻位/对位导向基团的亚硝化
标题:带有芳基化的芳烃的邻位/对位导向基团的亚硝化
摘要:在本文中,我们报道了荟萃芳烃的-Nitration轴承邻/对位用铱催化的c-H硼化反应之后是新开发的铜(II)粗频哪醇的芳基硼酸酯入的催化的变换引导组(多个)以一锅的方式对应的硝基芳烃.该协议允许的合成元-Nitrated芳烃是乏味来制备或使用现有的方法需要多步合成.该反应可耐受多种邻位/对位导向基团,例如-F,-Cl,-Br,-Ch 3,-Et,-I Pr-och 3和-ocf 3.它还提供对π电子缺陷杂环的硝基衍生物(例如吡啶和喹啉衍生物)的区域选择性访问.该方法的应用在复杂分子的后期修饰中以及在以克级制备到fda批准的药物nilotinib途中的中间体中得到了证明.最后,我们证明了通过该策略获得的硝基产物也可以通过baran的胺化方案直接转化为苯胺或受阻胺.
Doi:10.1002/chem.201901633

专利信息

专利号:CN-101658788-A
优先权日:2009-09-24
标 题:A catalyst for efficient catalytic hydrogenation of halogenated aromatic nitro compounds and green synthesis of halogenated aromatic amines and its preparation method

专利号:CN-101658788-B
优先权日:2009-09-24
标 题 :A catalyst for efficient catalytic hydrogenation of halogenated aromatic nitro compounds and green synthesis of halogenated aromatic amines and its preparation method

专利号:GB-1567300-A
优先权日:1977-03-28
标 题:Synthesis of biocidal 2-aryl-1,3-cycloalkane-diones and their enol esters

专利号:US-2019152962-A1
优先权日:2016-07-14
标题 :Cyclopropyl derivatives as ror-gamma modulators
发明人：DESAI RANJIT; KUMAR SANJAY S; PANDYA VRAJESH; DESAI JIGAR; RAVAL SAURIN
权利人:CADILA HEALTHCARE LTD
摘要:The present invention provides compounds which are modulators of RORγ and their use for the treatment of diseases or conditions mediated by RORγ. Further, the present invention relates to processes of preparing such compounds, their tautomeric forms, novel intermediates involved in their synthesis, their pharmaceutically acceptable salts, methods for using such compounds and pharmaceutical compositions containing them (Formula I).

专利号:WO-2018011747-A1
优先权日:2016-07-14
标 题 :Polycyclic compounds as ror-gamma modulators
发明人：DESAI RANJIT; KUMAR SANJAY S; PANDYA VRAJESH; DESAI JIGAR; RAVAL SAURIN
权利人:CADILA HEALTHCARE LTD
摘要:The present invention provides compounds which are modulators of RORγ and their use for the treatment of diseases or conditions mediated by RORγ. Further, the present invention relates to processes of preparing such compounds, their tautomeric forms, novel intermediates involved in their synthesis, their pharmaceutically acceptable salts, methods for using such compounds and pharmaceutical compositions containing them.

专利号:CN-104193699-B
优先权日:2014-08-14
标 题:A kind of small molecule compound and its synthesis method and application