CAS: 20575-57-9; 7-Hydroxy-3-(3-Hydroxy-4-Methoxyphenyl)-4H-Chromen-4-One

该化合物是一种具有抗炎特性的天然酚类化合物,已经证明它抑制了亲炎酶和细胞外皮的活动,表现出了强效抗氧化剂和免疫性循环效应. Calycosin的治疗潜力在于它能够减少炎症和氧化性压力,使它成为各种药物应用的有前途的候选者.

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欧盟法规

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上下游产品

2,4-dihydroxyphenyl 3'-hydroxy-4-methoxybenzyl ketone orthoformic acid triethyl ester 7-Hydroxy-3-(4-methoxy-phenyl)-chromen-4-on homoisovanillic acid3',7-diacetoxy-4'-methoxyisoflavone calycosin-7-O-β-D-glucopyranoside

合成工艺路线路线简述

    1-(2,4-二羟基苯基)-2-(3-羟基-4-甲氧基苯基)乙酮,原甲酸三乙酯置于哌啶体系中,用 N,N-二甲基甲酰胺 用作溶剂,化学反应 1.0H,以62%的收率获得毛蕊异黄酮
    参考文献:Bhandari,Prabha; Crombie,Leslie; Daniels,Peter,Journal Of The Chemical Society. Perkin Transactions I,1992,# 7,P. 839-850
    标题:Bhandari,Prabha; Crombie,Leslie; Daniels,Peter,Journal Of The Chemical Society. Perkin Transactions I,1992,# 7,P. 839-850

    海关参考信息

    专利信息


    专利号:US-2007232495-A1
    优先权日:2006-03-24
    标题:Compositions and methods to add value to plant products, increasing the commercial quality, resistance to external factors and polyphenol content thereof
    发明人:NAPPA ALVARO O; LORENZINI FELIPE C; SANHUEZA ANDRES L
    权利人:NAPPA ALVARO O; LORENZINI FELIPE C; SANHUEZA ANDRES L
    摘要:The invention is related to compositions and methods that naturally protect plant tissues against ultraviolet radiation and temperature, thus giving protection against sunburn to plants, plant parts, fruits and/or flowers during their development. The invention is also related to compositions and methods to naturally improve the color of plants, plant parts, fruits and/or flowers by inducing the natural synthesis of flavonoids and anthocyanins present in plants. Likewise, the present invention is directed to improving the nutritional value of plants, plant parts, fruits and/or flowers by increasing the normal levels of polyphenolic compounds, especially flavonoids, present therein. Additionally, the present invention is related to compositions and methods that give more resistance to plants, plant parts, fruits and/or flowers against pathogens as bacteria and fungi. Finally, the present invention is related to plants, plant parts, fruits, flowers and/or propagating material treated with the compositions described in the present document.

    专利号:CN-119351239-B
    优先权日:2024-12-26
    标题:Recombinant pichia pastoris and application thereof in synthesis of stachyose and verbascose

    专利号:DE-69736840-T2
    优先权日:1996-12-24
    标 题 :SYNTHESIS OF NUCLEOSIDES AND POLYNUCLEOTIDES

    专利号:CN-119351239-A
    优先权日:2024-12-26
    标题 :Recombinant pichia pastoris and application thereof in synthesis of stachyose and verbascose

    专利号:CN-113179949-B
    优先权日:2021-04-29
    标题:Application of n-hexanol in inducing the growth of adventitious roots of Astragalus and the synthesis and accumulation of multiple active components of Astragalus

    专利号:US-2014315720-A1
    优先权日:2012-10-24
    标 题 :Polysaccharide ester microspheres and methods and articles relating thereto
    发明人:FALLON DENIS G; GARRETT THOMAS S; KIZER LAWTON E; ZAZZARA KAREN L; COMBS MICHAEL T; JOHNSON RICHARD K; DEHART GARY
    权利人:CELANESE ACETATE LLC
    摘要:A method for producing a polysaccharide ester microsphere may include forming a polysaccharide ester product from a polysaccharide synthesis, wherein the polysaccharide ester product comprises a polysaccharide ester and a solvent; diluting the polysaccharide ester product, thereby yielding a polysaccharide ester dope; and forming a plurality of polysaccharide ester microspheres from the polysaccharide ester dope. Suitable polysaccharides may include, but are not limited to, starch, cellulose, hemicellulose, algenates, chitosan, and any combination thereof. Esters thereof may be organic esters (e.g., acetate and the like), inorganic esters (e.g., sulfonates and the like), or combinations thereof. Further, the solids conent of the polysaccharide ester dope, in some instances, may be greater than about 16 wt %.
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    主要参考文献


    1: Deng M, Chen H, Long J, Song J, Xie L, Li X. Calycosin: a Review of its Pharmacological Effects and Application Prospects. Expert Rev Anti Infect Ther. 2021 Jul;19(7):911-925. doi: 10.1080/14787210.2021.1863145. Epub 2020 Dec 21.
    104:154277. doi: 10.1016/j.phymed.2022.154277. Epub 2022 Jun 15. 60(1):990-996. doi: 10.1080/13880209.2022.2067572.
    4: Shi X, Jie L, Wu P, Zhang N, Mao J, Wang P, Yin S. Calycosin mitigates chondrocyte inflammation and apoptosis by inhibiting the PI3K/AKT and NF-κB pathways. J Ethnopharmacol. 2022 Oct 28;297:115536. doi: 10.1016/j.jep.2022.115536. Epub 2022 Jul 14. 13(12):16009-16023. doi: 10.18632/aging.203093. Epub 2021 Jun 7.

    合成参考文献


    摘要:US EPA; Estimation Program Interface (EPI) Suite. Ver. 4.1. Jan, 2011. Available from, as of Feb 7, 2013:
    摘要:
    摘要:WHO; WHO Monographs on Selected Medicinal Plants - Volume 1. 295 pp (1999). Available from, as of May 21, 2013:
    摘要:Lyman WJ et al; Handbook of Chemical Property Estimation Methods. Washington, DC: Amer Chem Soc pp. 7-4, 7-5, 8-12 (1990)
    摘要:Full text: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3394397
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