乙烯酮置于乙醚,羟胺体系中,化学反应生成 乙酰氧肟酸 参考文献:Hurd; Cochran,Journal Of The American Chemical Society,1923,Vol. 45,P. 520 标题:Hurd; Cochran,Journal Of The American Chemical Society,1923,Vol. 45,P. 520
专利号:US-2023002312-A1 优先权日:2019-11-20 标题:A continuous flow process for the synthesis of hydroxamic acid 发明人:PIMPALE MILIND JAGANNATH; KINI PRASHANT VASANT 权利人:UPL LTD 摘要:The present invention relates to a process for the synthesis of hydroxamic acids by continuous flow process wherein said process comprising reacting alkyl ester with hydroxyl amine salt in presence of base in a microreactor system and continuously producing hydroxamic acid.
专利号:US-6127515-A 优先权日:1997-11-18 标 题:Functionalized resin for the synthesis of amides and peptides 发明人:MANFRE FRANCO; VANASSE BENOIT J; LABAUDINIERE RICHARD F; MORTON GEORGE C 权利人:AVENTIS PHARM PROD INC 摘要:This invention is directed to a functionalized amino resin of formula ##STR1## wherein S is a solid support; R is H or alkyl; A is ##STR2## Y is OH or OCOR 1 ; and R 1 is aliphatic or aromatic which is useful for the solid phase synthesis of amides, peptides and hydroxamic acids.
专利号:US-5646319-A 优先权日:1995-06-23 标题:Synthesis of N-acyl-N-alkylcarboxylates 发明人:LETTON JAMES CAREY; MILLER LARRY EUGENE 权利人:PROCTER & GAMBLE 摘要:Chemical synthesis of N-acyl-N-alkylcarboxylates through oxidation of substituted amides formed from carboxylic acid esters and an N-alkyl-N-alkanolamine.
专利号:US-2011281893-A1 优先权日:2010-05-11 标 题 :Compound, synthesis, composition and uses thereof 发明人:KANDULA MAHESH 权利人:KANDULA MAHESH; KRISANI BIOSCIENCES P LTD 摘要:The instant application provides the disclosure for a compound of formula I, synthesis of compound of formula I and its pharmaceutical acceptable salts, as well as its polymorphs, solvates, and hydrates thereof. The pharmaceutically acceptable salt may be formulated for oral administration, systemic administration, transdermal administration and injection. The compound of formula I and its pharmaceutical compositions may be used to treat cancer in mammal.
专利号:US-2003157061-A1 优先权日:2001-12-05 标 题 :Combinations of a cyclooxygenase-2 selective inhibitor and a TNFalpha antagonist and therapeutic uses therefor 发明人:BENNETT DENNIS A 权利人:PHARMACIA CORP 摘要:A method for the prevention, treatment, or inhibition of pain, inflammation, or inflammation-related disorder and for the prevention, treatment, or inhibition of a cardiovascular disease or disorder in a subject that is in need of such prevention, treatment or inhibition, involves the administration to the subject of a cyclooxygenase-2 selective inhibitor or prodrug thereof and a TNFα antagonist. A method can also involve the treatment, prevention, or inhibition of cancer in a subject in need of such treatment, prevention, or inhibition, by administering to the subject a cyclooxygenase-2 selective inhibitor or prodrug thereof and a TNFα antagonist which is selected from the group consisting of a compound that affects the synthesis of TNFα, a compound that inhibits the binding of TNFα with a receptor specific for TNFα, and a compound that interferes with intracellular signaling triggered by TNFα binding with a receptor. Compositions, pharmaceutical compositions and kits that can be used with the methods are also described.
专利号:US-8987504-B2 优先权日:2010-06-18 标题 :Aminohydroxylation of alkenes 发明人:MEE SIMON PETER HAROLD; LUXENBURGER ANDREAS; HARRIS LAWRENCE DANIEL 权利人:MEE SIMON PETER HAROLD; LUXENBURGER ANDREAS; HARRIS LAWRENCE DANIEL; VICTORIA LINK LTD 摘要:The invention relates to a process for the aminohydroxylation of alkenes using N-oxycarbamate reagents, e.g. N-acyloxycarbamate, N-alkyloxycarbonyloxycarbamate and N-aralkoxycarbonyloxycarbamate reagents. The invention particularly relates to an intermolecular aminohydroxylation reaction that can be carried out in the absence of added base. The invention also relates to novel N-oxycarbamate reagents that are stable crystalline materials. The process of the invention is useful in the synthesis of compounds having a vicinal amino alcohol moiety, such as biologically active compounds.
1: Liu Q, Ni WW, Li Z, Bai CF, Tan DD, Pu CJ, Zhou D, Tian QP, Luo N, Tan KL, Dai L, Yan Y, Pei Y, Li XH, Zhu HL, Xiao ZP. Resolution and evaluation of 3-chlorophenyl-3-hydroxypropionylhydroxamic acid as antivirulence agent with excellent eradication efficacy in Helicobacter pylori infected mice. Eur J Pharm Sci. 2018 May 31. pii: S0928-0987(18)30254-9. doi: 10.1016/j.ejps.2018.05.029. [Epub ahead of print] doi: 10.1016/j.jmgm.2018.04.018. [Epub ahead of print] doi: 10.1021/acs.est.8b00164. Epub 2018 May 16. doi: 10.1021/acs.jpca.8b02300. Epub 2018 Apr 9. doi: 10.1371/journal.pbio.2003887. eCollection 2018 Jan. 6: Neselioglu S, Ergin M, Erel O. A New Kinetic, Automated Assay to Determine the Ferroxidase Activity of Ceruloplasmin. Anal Sci. 2017;33(12):1339-1344. doi: 10.2116/analsci.33.1339. doi: 10.1021/acs.jpca.7b09461. Epub 2017 Dec 26. doi: 10.1016/j.biopha.2017.10.015. Epub 2017 Nov 24. Review. pii: E1696. doi: 10.3390/molecules22101696. doi: 10.1111/cbdd.13088. Epub 2017 Sep 18. doi: 10.2215/CJN.11201016. Epub 2017 Aug 22. Review. 12: Macegoniuk K, Grela E, Biernat M, Psurski M, Gościniak G, Dziełak A, Mucha A, Wietrzyk J, Berlicki Ł, Grabowiecka A. Aminophosphinates against Helicobacter pylori ureolysis-Biochemical and whole-cell inhibition characteristics. PLoS One. 2017 Aug 9;12(8):e0182437. doi: 10.1371/journal.pone.0182437. eCollection 2017.
合成参考文献
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