专利号:US-11938546-B2 优先权日:2018-10-18 标题:Precision control of large-scale green synthesis of biodegradable gold nanodandelions as potential radiotheranostics 发明人:LO LEU-WEI; CHUANG YAO-CHEN 权利人:NATIONAL HEALTH RES INST; LO LEU WEI 摘要:The present invention relates to a new type of metabolizable flower-like gold nanodandelion (GND), which possesses features: (1) large scale green synthesis with high monodispersity and a circa 100% yield; (2) cellular/physiological degradability; (3) precision control of the shape, petal number and size; (4) highly efficient radiotheranostics encompassing better enhanced CT contrast and pronounced x-ray induced ROS generation than conventional spherical AuNP.
专利号:US-6448412-B1 优先权日:1995-07-31 标题:Methods for the preparation and characterization of multi-substituted fullerenes 发明人:MURPHY RANDALL B; WILSON STEPHEN R; LU QUING 权利人:SPHERE BIOSYSTEMS INC 摘要:The invention is directed to multiply-substituted fullerene derivatives of novel configurations, and methods for their preparation and use. The methods involve the combinatorial synthesis of a library of fullerene derivatives and comprises the steps of forming a mixture of fullerene derivatives by reacting the C n fullerene with two or more reactive precursor compounds, and removing the unreacted compounds to yield the fullerene derivatives having the desired activity. Methods for the identification and screening of a combinatorial library of fullerenes by 3 He-nuclear magnetic resonance and electrospray mass spectrometry to define members with the optimal desired activity are also provided.
专利号:US-9611281-B2 优先权日:2013-12-05 标题:BODIPY derivatives and methods of synthesis and use thereof 发明人:YOU YOUNGJAE; AWUAH SAMUEL; WATLEY RYAN 权利人:UNIV OKLAHOMA 摘要:Derivatives of BODIPY (boron dipyrromethene difluoride) and their synthesis and use are disclosed.
专利号:US-2009054649-A1 优先权日:2005-09-22 标题 :Bridged Organosilane and Production Method Thereof 发明人:SHIMADA TOYOSHI; GOTO YASUTOMO; INAGAKI SHINJI; MIZOSHITA NORIHIRO; IKAI MASAMICHI 权利人:TOYOTA CHUO KENKYUSHO KK; TOYOSHI SHIMADA 摘要:Provided is a bridged organosilane, which has a large complex organic group, and which is useful in the synthesis of a mesoporous silica and a light-emitting material, and a production method of the bridged organosilane. The bridged organosilane is expressed by the following general formula (1): n n n n n n n n n n [in the formula (1), q represents an integer in a range from 2 to 4, X 1 — represents a substituent selected from the group consisting of substituents expressed by the following general formulae (2) to (5): n n n n n n n n n n (in the formulae (2) to (5), R 1 represents alkyl group having 1 to 5 carbon atoms, R 2 represents an allyl group, and n represents an integer in a range from 0 to 3, and m represents an integer in a range from 0 to 6), and A 1 represents an organic group expressed by, for example, the following general formula (6): n n n n n n n n n n (in the formula (6), Y 1 < represents a substituent expressed by, for example, Oâ•?<)].
专利号:TW-202015706-A 优先权日:2018-10-18 标题 :Synthesis of degradable flower-like gold nanoparticles and its use for radiological diagnosis and treatment
专利号:WO-2020081088-A1 优先权日:2018-10-18 标题:Precision control of large-scale green synthesis of biodegradable gold nanodandelions as potential radiotheranostics