CAS: 78587-05-0; (S,S)-Hexythiazox

该化合物是一种化学化合物,被归类为杀螨剂,主要用于农业,以控制各种作物的微生物群;它属于硫化碘化合物类别,其特点是独特的分子结构,其中包括一个硫酸盐环;Hexythiazox功能,它抑制了红斑的发育,特别是在蛋和幼虫的生长阶段,从而扰乱了它们的生命周期;众所周知,它对哺乳动物和有益昆虫的毒性相对较低,使其成为综合虫害管理的一种首选;该化合物通常用作花生喷雾,对一系列微生物有效使用;其行动方式涉及干扰目标虫害的...

结构式图片

欧盟法规

[欧盟农药活性物质

上下游产品

trans-4-methyl-5-(4-chlorophenyl)-2-thiazolidone Cyclohexyl is°Cyanate 4'-chloropropiophenone 1-(4-chlorophenyl)-2-(hydroxyimino)propan-1-one

合成工艺路线路线简述

    Trans-4-Methyl-5-(4-Chlorophenyl)-2-Thiazolidone,环己基异氰酸酯 以 二甲基亚砜作为反应溶剂,获得 Hexythiazox
    参考文献:Heteroyclic Compounds
    标题:Heteroyclic Compounds
    摘要:一种化合物的分子式为##str1##其中x,Y和z的典型表示形式为氧或硫;R.Sub.1为甲基;R.Sub.2为苯基,取代基为氯,甲基,甲氧基,硝基或亚甲氧基;R.Sub.3为环己基,甲基环己基或四氢吡喃基,可用作杀螨剂.

    海关参考信息

    专利信息


    专利号:US-10423780-B1
    优先权日:2016-08-04
    标 题 :System and method for synthesis of correct-by-construction cryptographic software from specification
    发明人:KOPYLOV ALEXEI; NOGIN ALEKSEY
    权利人:HRL LAB LLC
    摘要:Described is a system for synthesis of cryptographic software from specification. During operation, the system generates a first level formalization code of a cryptographic protocol based on a user input protocol specification and a library of transformation rules. A second level formalization code is then generated by implementing communication protocols to the first level formalization code. A third level formalization code subsequently generated by implementing cryptographic primitives to the second level formalization code. Finally, the third level formalization code is encoded on a computer readable medium as an executable code.

    专利号:EP-1397373-B1
    优先权日:2001-06-07
    标 题 :Improved synthesis of allofuranose
    发明人:KOCH TROELS; HANSEN HENRIK FRYDENLUND
    权利人:SANTARIS PHARMA AS
    摘要:The present invention provides a novel strategy for the synthesis of allofuranose using glucofuranose as starting material in a one-pot reaction. The novel finding is that it is possible to carry out the oxidation of 1,2: 5,6-di-O-isopropylidene- alpha -D-glucofuranose with DMSO/acetic anhydride and a reduction reaction in one pot obtaining high yields of recrystallised and analytical pure 1,2:5,6-di-O-isopropylidene- alpha -D-allofuranose.

    专利号:US-6858726-B2
    优先权日:2001-06-07
    标 题:Synthesis of allofuranose
    发明人:KOCH TROELS; HANSEN HENRIK FRYDENLUND
    权利人:SANTARIS PHARMA AS
    摘要:The present invention provides a novel strategy for the synthesis of allofuranose using glucofuranose as starting material in a one-pot reaction. The novel finding is that it is possible to carry out the oxidation of 1,2:5,6-di-O-isopropylidene-alpha-D-glucofuranose with DMSO/acetic anhydride and a reduction reaction in one pot obtaining high yields of recrystallised and analytical pure 1,2:5,6-di-O-isopropylidene-alpha-D-allofuranose.

    专利号:WO-2025056767-A1
    优先权日:2023-09-15
    标题 :Process for the preparation of enantiomerically enriched aliphatic amines
    发明人:BOU HAMDAN FARHAN; GODINEAU EDOUARD; SMEJKAL TOMAS; DUMEUNIER RAPHAEL; BOUSSEMGHOUNE MOHAMED ABDELOUAHAB; BLUM MATHIAS
    权利人:SYNGENTA CROP PROTECTION AG
    摘要:The present invention relates to a process for the preparation of enantiomerically enriched cyclobutylamines of formula (I) from α-tertiary cyclobutanones and reacting said enantiomerically enriched cyclobutylamines to enantiomerically enriched cyclobutylamides. Such compounds are useful intermediates in the synthesis of microbiocidal thiazole compounds.

    专利号:US-2016073631-A1
    优先权日:2013-03-04
    标 题 :Process for the preparation of dihydropyrrole derivatives
    发明人:EL QACEMI MYRIEM; SMITS HELMARS; CASSAYRE JEROME YVES; MULHOLLAND NICHOLAS PHILLIP; RENOLD PETER; GODINEAU EDOUARD; PITTERNA THOMAS
    权利人:SYNGENTA PARTICIPATIONS AG; SYNGENTA LTD
    摘要:The present invention provides stereoselective processes for the preparation of compounds of formula (I) n n n n n n n n n n n n wherein n P is phenyl, naphthyl, a 6-membered heteroaryl group containing one or two nitrogen atoms as ring members, or a 10-membered bicyclic heteroaryl group containing one or two nitrogen atoms as ring members, and wherein the phenyl, naphthyl and heteroaryl groups are optionally substituted; n R 1 is chlorodifluoromethyl or trifluoromethyl; n R 2 is optionally substituted aryl or optionally substituted heteroaryl; n n is 0 or 1; n including the process comprising n (a-i) reacting a compound of formula II n n n n n n n n n n n n n n n n wherein P, R 1 and R 2 are as defined for the compound of formula I; n with nitromethane in the presence a chiral catalyst to give a compound of formula III n n n n n n n n n n n n n n n n wherein P, R 1 and R 2 are as defined for the compound of formula I; and n (a-ii) reductively cyclising the compound of formula III to give the compound of formula I. n n n n n The invention also provides intermediates useful for processes for the synthesis of compounds of formula (I).

    专利号:US-9233920-B2
    优先权日:2010-06-11
    标题 :Process for the preparation of dihydropyrrole derivatives
    发明人:EL QACEMI MYRIEM; SMITS HELMARS; CASSAYRE JEROME YVES; MULHOLLAND NICHOLAS PHILLIP; RENOLD PETER; GODINEAU EDOUARD; PITTERNA THOMAS
    权利人:EL QACEMI MYRIEM; SMITS HELMARS; CASSAYRE JEROME YVES; MULHOLLAND NICHOLAS PHILLIP; RENOLD PETER; GODINEAU EDOUARD; PITTERNA THOMAS; SYNGENTA PARTICIPATIONS AG; SYNGENTA LTD
    摘要:The present invention provides stereoselective processes for the preparation of compounds of formula (I) wherein P is phenyl, naphthyl, a 6-membered heteroaryl group containing one or two nitrogen atoms as ring members, or a 10-membered bicyclic heteroaryl group containing one or two nitrogen atoms as ring members, and wherein the phenyl, naphthyl and heteroaryl groups are optionally substituted; R 1 is chlorodifluoromethyl or trifluoromethyl; R 2 is optionally substituted aryl or optionally substituted heteroaryl; n is 0 or 1; including the process comprising (a-i) reacting a compound of formula II wherein P, R 1 and R 2 are as defined for the compound of formula I; with nitromethane in the presence a chiral catalyst to give a compound of formula III Wherein P, R 1 and R 2 are as defined for the compound of formula I; and (a-ii) reductively cyclizing the compound of formula III to give the compound of formula I. The invention also provides intermediates useful for processes for the synthesis of compounds of formula (I).
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    主要参考文献


    1: Demaeght P, Osborne EJ, Odman-Naresh J, Grbić M, Nauen R, Merzendorfer H, Clark RM, Van Leeuwen T. High resolution genetic mapping uncovers chitin synthase-1 as the target-site of the structurally diverse mite growth inhibitors clofentezine, hexythiazox and etoxazole in Tetranychus urticae. Insect Biochem Mol Biol. 2014 Aug;51:52-61. doi: 10.1016/j.ibmb.2014.05.004. Epub 2014 May 22.
    2: Yorulmaz Salman S, Ay R. Effect of hexythiazox and spiromesifen resistance on the life cycle of the predatory mite Neoseiulus californicus (Acari: Phytoseiidae). Exp Appl Acarol. 2014 Oct;64(2):245-52. doi: 10.1007/s10493-014-9817-8. Epub 2014 Apr 29. doi: 10.1016/j.foodchem.2014.10.015. Epub 2014 Oct 18. doi: 10.1016/j.foodchem.2015.10.052. Epub 2015 Oct 22. doi: 10.1021/jf202144p. Epub 2011 Oct 19. Portuguese. doi: 10.1016/j.talanta.2005.08.025. Epub 2005 Sep 15. doi: 10.1111/1744-7917.12190. Epub 2015 Jan 29. doi: 10.1002/ps.3330. Epub 2012 Jul 13. doi: 10.1603/EC14064. doi: 10.1080/19440049.2015.1050460. Epub 2015 Jun 8. doi: 10.1021/acs.jafc.5b00795. Epub 2015 Apr 24. doi: 10.1016/j.pestbp.2014.12.009. Epub 2014 Dec 12. Review. doi: 10.1673/031.014.104. doi: 10.1016/j.chroma.2014.11.079. Epub 2014 Dec 18. doi: 10.1002/ps.3623. Epub 2013 Aug 30. doi: 10.1016/j.jhazmat.2013.11.016. Epub 2013 Nov 16. doi: 10.1093/jee/tov189. Epub 2015 Jul 3.

    合成参考文献


    参考文献:10.1007/s10493-005-1423-3
    摘要:Pree DJ, Whitty KJ, Van Driel L. Baseline Susceptibility and Cross Resistances of Some New Acaricides in the European Red Mite, Panonychus ulmi*. Experimental and Applied Acarology. 2005 Dec;37(3-4):165. doi: 10.1007/s10493-005-1423-3.
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