CAS: 994-30-9; Chlorotriethylsilane

相似化合物

995-45-9 995-25-5 13154-24-0

上下游产品

CAS号2117-34-2 三乙基甲氧基硅烷 | CAS号597-52-4 三乙基硅烷醇 | CAS号617-86-7 三乙基硅烷 | CAS号994-49-0 六乙基二硅氧烷 | CAS号544-10-5 氯(代)正己烷 | CAS号75-44-5 光气 | CAS号75-77-4 三甲基氯硅烷 | CAS号107-06-2 1,2-二氯乙烷 | CAS号2117-17-1 [amino(diethyl)... | CAS号3550-35-4 二甲胺基三乙基硅烷 | CAS号150811-54-4 methyl 2-trieth... | CAS号14629-52-8 Triethylpentoxy... | CAS号1427-33-4 trimethyl(1,2,2... | CAS号14629-62-0 Phenethyl(triet... | CAS号14579-57-8 三(三乙基硅基)磷酸酯 | CAS号37968-97-1 4,4'-联吡啶硫 | CAS号1777-03-3 (三乙基硅烷基)乙炔 | CAS号17947-98-7 BIS(TRIETHYLSIL... | CAS号1112-54-5 三乙基乙烯基硅烷

三乙基(甲氧基)硅烷置于盐酸体系中,用 正己烷 作为反应溶剂,化学反应 2.0H,以72%的收率获得产物三乙基氯硅烷
参考文献:由具有大取代基的烷氧基硅烷,硅烷醇和氢硅烷合成氯硅烷
标题:由具有大取代基的烷氧基硅烷,硅烷醇和氢硅烷合成氯硅烷
摘要:我们已经发现,商业上重要的三烷基氯硅烷可以通过烷氧基硅烷,硅烷醇和氢硅烷与浓盐酸水溶液的反应而容易地合成.带有庞大的烷基取代基的三烷基烷氧基硅烷的处理,例如i-Pr,仲-Bu,叔-Bu和环用35%盐酸水溶液的-Hex基团以优异的收率获得产物相应的三烷基氯硅烷.用35%的盐酸水溶液对三烷基硅烷醇进行类似的处理也以几乎定量的收率获得产物了三烷基氯硅烷.甲基三氯硅烷和二甲基二氯硅烷与带有庞大烷基的烷基格氏试剂反应,然后用浓盐酸水溶液处理所得混合物,以高收率生产了相应的二烷基甲基和烷基二甲基氯硅烷.在钯催化剂的存在下,用浓盐酸处理三烷基氢硅烷,可以高收率得到三烷基氯硅烷.
DOI:10.1016/j.Jorganchem.2005.08.028

专利信息

专利号:US-11548898-B2
优先权日:2017-07-06
标题 :Synthesis of halichondrins
发明人：KISHI YOSHITO; AI YANRAN; YE NING; WANG QIAOYI; YAHATA KENZO; ISO Kentaro; NAINI SANTHOSH REDDY; YAMASHITA SHUJI; LEE JIHOON; OHASHI ISAO; FUKUYAMA TAKASHI
权利人:HARVARD COLLEGE; EISAI R&D MAN CO LTD
摘要:The present invention provides methods for the synthesis of ketones involving a Ni/Zr-mediated coupling reaction. The Ni/Zr-mediated ketolization reactions can be used in the synthesis of halichondrins (e.g., halichondrin A, B, C; homohalichondrin A, B, C; norhalichondrin A, B, C), and analogs thereof. Therefore, the present invention also provides synthetic methods useful for the synthesis of halichondrins, and analogs thereof. Also provided herein are compounds (i.e., intermediates) useful in the synthesis of halichondrins, and analogs thereof. In particular, the present invention provides methods and compounds useful in the synthesis of compound of Formula (H3-A).

专利号:US-7420052-B2
优先权日:2001-08-24
标 题:Intermediates for synthesis of vinblastine, process for preparation of the intermediates and process for synthesis of vinblastines
发明人：FUKUYAMA TOHRU; TOKUYAMA HIDETOSHI; YOKOSHIMA SATOSHI
权利人:JAPAN SCIENCE & TECH AGENCY
摘要:An intermediate for vinblastine synthesis represented by general formula A. n ngeneral formula A.n n(in the formula, R 1 , R 2 , R 3 and R 4 are the group selected independently from the group consisting of H, lower alkyl group, lower alkoxy group, halogen, lower perfluoroalkyl group, lower alkylthio group, hydroxy group, amino group, mono- or di-alkyl or acylamino group, lower alkyl or arylsulfonyloxy group. R 5 is H, or a lower alkyl group or a substituted or non-substituted aryl group, R 6 is an alkyl group of carbon number 4 or less, R 7 is a substituted or non-substituted aryl group, R 8 is a substituted or non-substituted aryl group or lower alkyl group and R 9 is an acyl group or trialkylsilyl group.) A method for synthesis of the compound of general formula A utilizing radical ring forming reaction of thioanilides and using the compound of general formula B as the starting material, synthesizing thioanilide of general formula C by the reaction with compound 1 and the formation of a 11-membered ring by intramolecular alkylation of 2-nitrobenzenesulfonamide by which the reactions can proceed under mild conditions and high yield can be accomplished.

专利号:WO-2022256490-A9
优先权日:2021-06-03
标题:Improved synthesis of phosphoramidates for the treatment of hepatitis b virus
发明人：LOCKWOOD MARK
权利人:ANTIOS THERAPEUTICS INC
摘要:The synthesis of phosphoramidate prodrugs useful in the treatment of viral infections is disclosed. Specifically, an improved synthesis of phosphoramidate nucleotides useful in the treatment of Hepatitis B virus is disclosed.

专利号:US-2004018598-A1
优先权日:2000-05-30
标题 :Bio-intermediates for use in the chemical synthesis of polyketides
发明人：SANTI DANIEL; ASHLEY GARY; MYLES DAVID C
摘要:The present invention relates to compounds made by a subset of modules from one or more polyketide synthase (“PKS†) genes that are used as starting material in the chemical synthesis of novel molecules, particularly naturally occurring polyketides or derivatives thereof. The biologically derived intermediates (“bio-intermediates†) generally represent particularly difficult compounds to synthesize using traditional chemical approaches due to one or more stereocenters. In one aspect of the invention, an intermediate in the synthesis of epothilone is provided that feeds into the synthetic protocol of Danishefsky and co-workers. In another aspect of the invention, intermediates in the synthesis of discodermolide are provided that feed into the synthetic protocol of Smith and co-workers. By taking advantage of the inherent stereochemical specificity of biological processes, the syntheses of key intermediates and thus the overall syntheses of compounds like epothilone and discodermolide are greaty simplified.

专利号:US-8293930-B1
优先权日:2004-06-25
标题 :One pot synthesis of taxane derivatives and their conversion to paclitaxel and docetaxel
发明人：NAIDU RAGINA
权利人:NAIDU RAGINA; CHATHAM BIOTEC LTD
摘要:A process is provided for the semi-synthesis of taxane intermediates useful in the preparation of paclitaxel and docetaxel, in particular, the semi-synthesis of protected taxane intermediate in a one pot reaction of protecting the C-7 and C-10 positions and attaching a side chain at the C-13 position and subsequently deprotecting the group to form paclitaxel or docetaxel, and taxane intermediates.

专利号:US-7893283-B2
优先权日:2004-06-04
标题:Semi-synthesis of taxane intermediates and their conversion to paclitaxel and docetaxel
发明人：NAIDU RAGINA
权利人:CHATHAM BIOTEC LTD
摘要:A process is provided for the semi-synthesis of taxane intermediates useful in the preparation of paclitaxel and docetaxel, in particular, the semi-synthesis of protected taxane intermediates.