CAS: 99548-54-6; Methyl 3-Bromo-2-Methylbenzoate

上下游产品

3-溴-2-甲基苯甲酸 3-Bromo-2-Methylbenzoic Acid 76006-33-2
2-甲基-5-溴苯甲酸 5-Bromo-2-Methylbenzoic Acid 79669-49-1

3-溴-2-甲基苯甲酸置于硫酸体系中,用 甲醇 作为反应溶剂,化学反应生成 2-甲基-3-溴苯甲酸甲酯
参考文献:1-Substituted Phenyl-1-(1H-Imidazol-4-yl) Alcohols,Process For Producing The Same And Use Thereof
标题:1-Substituted Phenyl-1-(1H-Imidazol-4-yl) Alcohols,Process For Producing The Same And Use Thereof
摘要:提供一种具有类固醇c17,20-裂解酶抑制活性的化合物,并且作为预防或治疗前列腺增生和乳腺癌等肿瘤的药物.所述化合物的结构式如下:其中r为氢原子或保护基,R1为较低的烷基或环烃基,R2为芳香烃基,可选择地具有取代基,或芳香杂环基,可选择地具有取代基,R3为烃基,可选择地具有取代基,羟基,可选择地具有取代基,硫醇基,可选择地具有取代基,氨基,可选择地具有取代基,酰基或卤原子,N为0到4的整数,以及其盐具有类固醇c17,20-裂解酶抑制活性,并且作为预防或治疗前列腺增生和乳腺癌等肿瘤的药物.

专利信息

专利号:US-2018065917-A1
优先权日:2016-09-02
标 题 :Immune checkpoint inhibitors, compositions and methods thereof
发明人：WEBBER STEPHEN E; ALMASSY ROBERT J
权利人:POLARIS PHARMACEUTICALS INC
摘要:The present invention provides synthesis, pharmaceutically acceptable formulations and uses of compounds in accordance with Formula (I), or a stereoisomer, a tautomer or a pharmaceutically acceptable salt thereof. n n n n n n n n n n For Formula (I) compounds R 1 , R 2 , X 1 , Y 1 and n are as defined in the specification. The inventive Formula (I) compounds are inhibitors of the PD-1/PD-L1 protein/protein binding or functional interaction and find utility in any number of therapeutic applications, including but not limited to treatment of proliferative disorders such as cancer and infectious diseases.

专利号:CN-110177551-B
优先权日:2016-11-11
标 题:Heterocyclic modulators of lipid synthesis