CAS: 125995-03-1; 5-(4-Fluorophenyl)-1-(2-((2R,4R)-4-Hydroxy-6-Oxotetrahydro-2H-Pyran-2-yl)Ethyl)-2-Isopropyl-N,4-Diphenyl-1H-Pyrrole-3-Carboxamide

上下游产品

CAS号842163-03-5 (2R,4R)-1-[2-(4... | CAS号134523-00-5 阿伐他汀 | CAS号581772-29-4 Atorvastatin ac... | CAS号125971-86-0 tert-butyl 2-((... | CAS号125971-96-2 4-氟-α-[2-甲基-1-氧... | CAS号340266-37-7 [R-(R*,R*)]-2-(... | CAS号125971-95-1 (4R,6R)-2-[6-[2... | CAS号67-56-1 甲醇 | CAS号110862-44-7 α-[[2-(1,3-diox... | CAS号134523-01-6 阿伐他汀钠

Lipitor置于盐酸体系中,用 水 用作溶剂,化学反应 2.0H,以55%的收率获得阿托伐他汀内酯
参考文献:用强酸处理后形成的两种新的阿托伐他汀钙降解产物的表征
标题:用强酸处理后形成的两种新的阿托伐他汀钙降解产物的表征
摘要:阿托伐他汀钙(立普妥®,Sortis ®)是一种建立非常好的胆固醇合成酶(cse)抑制剂,通常用于治疗高胆固醇血症.已知该药物对酸处理敏感,但有关降解产物的结构的数据很少.在这里,我们报告鉴定两个仅在剧烈酸性条件下形成的阿托伐他汀的新型降解产物.同时用浓密治疗.用浓硫酸处理会导致羧酰苯胺残留物的损失(伴随侧链预期的内酯化/脱水过程).在盐酸水溶液中,内酯部分与吡咯在c-C键下形成复杂的桥连分子,异丙基迁移,羧酰苯胺残基丢失.通过NMR光谱对新型降解产物进行了表征,
Doi:10.3762/bjoc.15.206

专利信息

专利号:US-2007015260-A1
优先权日:2002-03-14
标 题:Synthesis of synthons for the manufacture of bioactive compounds
发明人：WONG CHI-HUEY; LIU JUNJIE; DESANTIS GRACE; BURK MARK
权利人:SCRIPPS RESEARCH INST
摘要:The present invention is based on the discovery that 2-deoxyribose-5-phosphate aldolase (DERA, EC 4.1.2.4) and variants thereof can be used to catalyze sequential asymmetric aldol reactions between a wide variety of donor and acceptor aldehydes. The reaction products typically contain at least two new stereogenic centers and can be produced in enantiomerically pure form. As such, DERA catalyzed asymmetric aldol chemistry can be exploited to produce synthons for the synthesis of a variety of bioactive molecules.

专利号:US-10647655-B2
优先权日:2016-09-02
标题:Method for the synthesis of permethrin
发明人：PULLAGURLA MANIK REDDY; NANDA KUMAR MECHERIL VALSAN; VELIGETLA MADHUSUDHANA RAO; RANGISETTY JAGADEESH BABU
权利人:BIOPHORE INDIA PHARMACEUTICALS PVT LTD
摘要:An improved method for the synthesis of substantially pure Permethrin having purity greater than 99.5% by Gas Chromatography provided. The embodiments also relates to a purification process of Permethrin by recrystallization from methanol-water mixture.

专利号:US-7399773-B2
优先权日:2001-01-09
标 题 :Process for the synthesis of 5-(4-fluorophenyl)-1-[2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid and phenylamide
发明人：NELSON JADE DOUGLAS; PAMMENT MICHAEL GERARD
权利人:WARNER LAMBERT CO
摘要:An improved process for the preparation of 5-(4-fluorophenyl)-1-[2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid phenylamide by a novel synthesis is described where methyl cyanoacetate is converted in eight operations or fewer to the desired product, as well as other valuable intermediates used in the process.

专利号:US-7232915-B2
优先权日:1997-12-19
标题:Process for the synthesis of 1,3-diols
发明人：BOSCH ROBERT LEE; MCCABE RICHARD JOSEPH; NANNINGA THOMAS NORMAN; STAHL ROBERT JOSEPH
权利人:WARNER LAMBERT CO
摘要:An improved process for the preparation of cis-1,3-diols is described where a beta hydroxy ketone is treated with a trialkylborane or dialkylalkoxyborane or a mixture of a trialkylborane and a dialkylalkoxyborane followed by recovery and reuse of the alkylborane species to convert additional beta hydroxy ketone to the cis-1,3-diol.

专利号:US-5155251-A
优先权日:1991-10-11
标题:Process for the synthesis of (5R)-1,1-dimethylethyl-6-cyano-5-hydroxy-3-oxo-hexanoate
发明人：BUTLER DONALD E; LE TUNG V; MILLAR ALAN; NANNINGA THOMAS N
权利人:WARNER LAMBERT CO
摘要:An improved process for the preparation of (5R)-1,1-dimethylethyl-6-cyano-5-hydroxy-3-oxo-hexanoate is described where a halo hydroxyester or other activated dihydroxyester is converted in two steps to the desired product.

专利号:US-5248793-A
优先权日:1990-10-17
标 题:Process for the synthesis of (4R-cis)-1,1-dimethylethyl 6-iodomethyl or 6-(phenyl-substituted)sulfonyloxymethyl-2,2-dimethyl-1,3-dioxane-4-acetate
发明人：MILLAR ALAN; BUTLER DONALD E
权利人:WARNER LAMBERT CO
摘要:An improved process for the preparation of (4R-cis)-1,1-dimethylethyl 6-cyanomethyl-2,2-dimethyl-1,3-dioxane-4-acetate is described where a hydroxy ester derivative is converted in two steps to the desired product, as well as valuable intermediates used in the process.