专利号:US-9512426-B2 优先权日:2009-12-17 标 题:Method for rapidly evaluating performance of short interfering RNA with novel chemical modifications 发明人:BUTORA GABOR; DAVIES IAN W; FLANAGAN WILLIAM MICHAEL; FU WENLANG; KENSKI DENISE M; QI NING 权利人:SIRNA THERAPEUTICS INC 摘要:It is an object of the instant invention to provide a method for the rapid evaluation of novel sugar modifications to be used in siRNA synthesis including the rapid evaluation of chemical modification patterns within the siRNA to effectuate increased stability and ultimately increased efficacy of a siRNA therapeutic. It is a further object of the instant invention to provide novel nucleosides useful for siRNA therapy.
专利号:WO-9325556-A1 优先权日:1992-06-18 标 题:Methods and intermediates for the asymmetric synthesis of camptothecin and camptothecin analogs
专利号:JP-3499554-B2 优先权日:1992-06-18 标题:Methods and intermediates for asymmetric synthesis of camptothecin and camptothecin analogs
专利号:WO-2010039922-A1 优先权日:2008-10-03 标 题:Calcilytic compounds 发明人:CASILLAS LINDA N; CHARNLEY ADAM KENNETH; DEMARTINO MICHAEL P; DONG XIAOYANG; HARRIS PHILIP ANTHONY; MARQUIS ROBERT W JR; RAMANJULU JOSHI M; TROUT ROBERT 权利人:GLAXOSMITHKLINE LLC; CASILLAS LINDA N; CHARNLEY ADAM KENNETH; DEMARTINO MICHAEL P; DONG XIAOYANG; HARRIS PHILIP ANTHONY; MARQUIS ROBERT W JR; RAMANJULU JOSHI M; TROUT ROBERT 摘要:Novel calcilytic compounds, pharmaceutical compositions, methods of synthesis and methods of using them are provided.
参考文献:10.1038/ncomms9580 摘要:Tamura M, Kishi R, Nakagawa Y, Tomishige K. Self-assembled hybrid metal oxide base catalysts prepared by simply mixing with organic modifiers. Nature Communications. 2015 Oct 05;6(1):8580. doi: 10.1038/ncomms9580.