CAS: 28549-12-4; (S)-2-Hydroxy-2-Phenylacetonitrile

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CAS号37577-28-9 左旋去甲麻黄碱 | CAS号492-39-7 Cathine | CAS号23364-44-5 (1S,2R)-2-氨基-1,...

(R)-(+)-苯乙醇腈置于甲烷磺酸,三苯基膦,偶氮二甲酸二乙酯体系中,用 甲醇 用作溶剂,化学反应生成羟基(苯基)乙腈
参考文献:Warmerdam,E. G. J. C.; Brussee,J.; Kruse,C. G.,Phosphorus,Sulfur And Silicon And The Related Elements,1993,Vol. 75,# 1-4,P. 3-6
标题:Warmerdam,E. G. J. C.; Brussee,J.; Kruse,C. G.,Phosphorus,Sulfur And Silicon And The Related Elements,1993,Vol. 75,# 1-4,P. 3-6

专利信息

专利号:WO-2007093765-A1
优先权日:2006-02-13
标题 :Process for the cyanation of aldehydes
发明人：NORTH MICHAEL; BELOKON YURI
权利人:NPIL PHARMACEUTICALS UK LTD; NORTH MICHAEL; BELOKON YURI
摘要:The present invention relates to a process for the cyanation of aldehydes, particularly to the asymmetric cyanation of aldehydes, including the synthesis of chiral cyanohydrins and derivatives thereof, such as chiral O-acyl cyanohydrins. The process of the present invention comprises: reacting the aldehyde with a cyanating agent in the presence of a chiral catalyst and less than a stoichiometric amount of an ionic cyanide source. Chiral catalysts employed in the process according to the present invention are of the formula: (1), (3a), (3b).

专利号:US-8940516-B2
优先权日:2006-12-08
标题:Method for the synthesis of chiral cyanohydrins via a hydroxynitrile lyase from brassicaceae
发明人：EGGERT THORSTEN; ANDEXER JENNIFER
权利人:EVOCATAL GMBH
摘要:The invention concerns a polypeptide which can be isolated from the Brassicaceae family and which has at least the activity of a hydroxynitrile lyase (HNL). The hydroxynitrile lyase of the invention is the first HNL from the Brassicaceae family. The plants ( Arabidopsis ) from which this enzyme or its gene is isolated is also described as non-cyanogenic. All HNL-containing plants described so far are cyanogenic plants and so it has until now been assumed that only cyanogenic plants contain hydroxynitrile lyases. Surprisingly, it transpires that a polypeptide (AtHNL) of the invention is (R)-selective. The amino acid sequence gives a theoretical molecular weight of 29.2 kDa for the AtHNL subunit. The calculated molecular mass of the protein of approximately 30 kDa can be confirmed by SDS gel electrophoresis.