CAS: 344423-98-9; Calcium (3R,5R)-7-(2-(4-Fluorophenyl)-5-Isopropyl-3-Phenyl-4-(Phenylcarbamoyl)-1H-Pyrrol-1-yl)-3,5-Dihydroxyheptanoate Trihydrate

2,4,7-Trimethoxychinolin置于正丁基锂,Sodium Hydride,二甲基亚砜体系中,用 四氢呋喃,乙醚 用作溶剂,化学反应 1.5H,反应生成阿托伐他汀钙三水合物
参考文献:线性呋喃喹啉生物碱的新合成
标题:线性呋喃喹啉生物碱的新合成
摘要:描述了一种新的合成方法,该方法使用二甲基s甲基化物从3-环氧乙烷基喹啉合成线性呋喃喹啉生物碱,十氢丁胺,γ-紫胶,Evolitrine和pteliene.
Doi:10.1016/j.Tetlet.2004.09.041

专利信息

专利号:US-7399773-B2
优先权日:2001-01-09
标 题 :Process for the synthesis of 5-(4-fluorophenyl)-1-[2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid and phenylamide
发明人：NELSON JADE DOUGLAS; PAMMENT MICHAEL GERARD
权利人:WARNER LAMBERT CO
摘要:An improved process for the preparation of 5-(4-fluorophenyl)-1-[2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid phenylamide by a novel synthesis is described where methyl cyanoacetate is converted in eight operations or fewer to the desired product, as well as other valuable intermediates used in the process.

专利号:WO-2008075165-A1
优先权日:2006-12-19
标 题 :Novel process for the synthesis of [r-(r*, r*)]-2-(4-fluorophenyl)-beta, delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrrole-1-heptanoic acid or a pharmaceutically acceptable salt thereof
发明人：CHOPRA TIMOTHY JAY; O'NEILL PADRAIG MARY; WILKES PHILIPPA BRENDA
权利人:PFIZER PROD INC; CHOPRA TIMOTHY JAY; O'NEILL PADRAIG MARY; WILKES PHILIPPA BRENDA
摘要:An improved synthesis for the preparation of [R-(R*, R*)]-2-(4-fluorophenyl)- β, δ-dihydroxy-5-(1- methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1 H-pyrrole-1-heptanoic acid or a pharmaceutically acceptable salt thereof, as well as other valuable intermediates used in the process, are described. The compounds prepared by a process of the invention are useful in treating hyperlipidemia, hypercholesterolemia, osteoporosis, benign prostatic hyperplasia, or Alzheimer's disease.

专利号:EP-2719288-A1
优先权日:2012-10-12
标 题:Composition for the treatment or prevention of dyslipidaemias
发明人：FULGA ION GIGEL; VASILE DANUT
权利人:FULGA ION GIGEL; VASILE DANUT
摘要:The invention is a composition consisting of a combination of a compound which decreases the synthesis of endogenous cholesterol with a compound that reduces cholesterol absorption, a compound that increases HDL and a compound that enhances cholesterol degradation, the ratio of the four compounds being 0.5...1: 0.5...1: 0.015: 1.5...2, expressed in parts by weight. Preferably, the composition according to the invention contains a combination of red rice yeast (or red rice extract) with niacin, sitostanol and taurine in oral pharmaceutical preparations to be used as food supplement or as medicine for the treatment or prevention of dyslipidaemias, for improving or preventing disturbances in the serum lipid profile.

专利号:US-2006122240-A1
优先权日:2002-11-05
标题 :Benzotriazoles and methods of prophylaxis or treatment of metabolic-related disorders thereof
发明人：SEMPLE GRAEME; SKINNER PHILIP J; CHERRIER MARTIN C; WEBB PETER; TAMURA SUSAN Y
权利人:ARENA PHARM INC
摘要:The present invention relates to certain benzotriazole carboxylic acid or ester derivatives of Formula (I), pharmaceutically acceptable salts and solvates thereof, which exhibit useful pharmaceutical properties, for example, as agonists for the GPCR referred to as hRUP38. Also provided by the present invention are pharmaceutical compositions containing compounds of the invention, and methods of using the compounds and compositions of the invention in the prophylaxis or treatment of metabolic-related disorders, including dyslipidemia, atherosclerosis, coronary heart disease, insulin resistance, type 2 diabetes, Syndrome-X and the like. In addition, the present invention also provides for the use of the compounds of the invention in combination with other active agents such as those belonging to the class of -glucosidase inhibitors, aldose reductase inhibitors, biguanides, HMG-CoA reductase inhibitors, squalene synthesis inhibitors, fibrates, LDL catabolism enhancers, angiotensin converting enzyme (ACE) inhibitors, insulin secretion enhancers and the like.

专利号:US-2008227846-A1
优先权日:2007-03-13
标 题:Methods of treating juvenile type 1 diabetes mellitus
发明人：SINGH INDERJIT; KEY LYNDON
权利人:MUSC FOUND FOR RES DEV; UNIV SOUTH CAROLINA
摘要:The present disclosure describes methods for treating or preventing Type 1 diabetes mellitus in juveniles, particularly in juveniles newly diagnosed with Type 1 diabetes. This prevention or treatment of Type 1 diabetes is achieved by administering one or more therapeutic agents to a juvenile in need, wherein the therapeutic agent is, for example, a competitive inhibitor of mevalonate synthesis, a competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, or an inducer of AMP protein kinase (AMPK) activity. In certain embodiments, juveniles with Type 1 diabetes are treated with an HMG-CoA reductase inhibitor such as a statin, thereby decreasing the destruction of islet cells, or maintaining endogenous insulin production, in the juvenile.

专利号:US-2008275104-A1
优先权日:1997-11-25
标 题 :Methods of treating juvenile type 1 diabetes mellitus
发明人：SINGH INDERJIT; KEY LYNDON
权利人:MUSC FOUND FOR RES DEV
摘要:The present disclosure describes methods for treating Type 1 diabetes mellitus in juveniles. This treatment of Type 1 diabetes is achieved by administering one or more therapeutic agents to a juvenile in need, wherein the therapeutic agent is, for example, a competitive inhibitor of mevalonate synthesis, a competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, or an inducer of AMP protein kinase (AMPK) activity. In certain embodiments, juveniles with Type 1 diabetes are treated with an HMG-CoA reductase inhibitor such as a statin.