CAS: 347-42-2; 2-(Trifluoromethyl)Quinoline

相似化合物

1075184-01-8 176722-64-8 176722-74-0

上下游产品

1-trifluoromethyl-3-(phenylamino)prop-2-en-1-one aniline p-toluidinep-toluidine 1-phenylimino-3-phenoxy-3-trifluoromethylprop-2-ene 2-(trifluoromethyl)quinoline-4-carboxylic acid 2-trifluoromethyl-8-quinolinecarboxylic acid 2-trifluoromethyl-3-quinolinecarboxylic acid

2-(三氟甲基)喹啉-4(1H)-酮置于正丁基锂,三溴氧磷体系中,用 四氢呋喃,正己烷 用作溶剂,化学反应 2.25H,反应生成2-三氟甲基喹啉
参考文献:2-(三氟甲基)喹啉酮的选择性和高效结构制备
标题:2-(三氟甲基)喹啉酮的选择性和高效结构制备
摘要:苯胺与 Et 4,4,4-三氟乙酰乙酸酯之间的酸催化环化-缩合反应得到 1,4-二氢-2-三氟甲基-4H-4-喹啉酮,可轻松转化为 4-溴-2-(三氟甲基)喹啉.当用丁基锂处理时,它们进行卤素/金属交换,反应生成2-三氟甲基-4-喹啉基锂,和氢/金属交换,当用二异丙基氨基锂处理时反应生成4-溴-2-三氟甲基-3-喹啉基锂.后一种中间体的捕获提供了 3 官能化的产物,可以通过溴原子的亲电取代进一步加工.这些调查产生了一些意想不到的发现,最值得注意的是前所未有的支撑效应和违反直觉的卤素反应性.[在 Scifinder (R) 上]
Doi:10.1002/ejoc.200390217

专利信息

专利号:US-7129357-B2
优先权日:2003-09-15
标题:Synthesis of quinoline 5-carboxamides useful for the preparation of PDE IV inhibitors
发明人：ANDREWS DAVID R; TANG SUHAN; WU WENXUE; KALLINEY SAMI Y; SUDHAKAR ANANTHA; NIELSEN CHRISTOPHER
权利人:SCHERING CORP
摘要:In one embodiment, the present application discloses a process for making the compound of the formula:

专利号:EP-1756029-B1
优先权日:2004-04-08
标 题:Novel compounds, the preparation and the use thereof for a regiospesific synthesis of perfluor(alkyl) group heterocycles
发明人：EL KHARRAT SALEM; LAURENT PHILIPPE; BLANCOU HUBERT
权利人:CENTRE NAT RECH SCIENT; UNIV MONTPELLIER II
摘要:The invention relates to compounds of formula (1), wherein Z is a hydrogen or halogen atom; R'F is a perfluoroalkyl group CnF2n+1 in which n is an integer ranging from 1 to 12; R is in an ortho, meta or para position and represents an electron donor group, an electron attracting group, an aryl group or a heteroaryl group with the provision that R is an aryl or a heteroaryl. A method for preparing the inventive compounds (1) and a method for preparing heterocyclic compounds therefrom are also disclosed.

专利号:US-6774125-B2
优先权日:1998-06-22
标 题:Deoxyamino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
发明人：AUDIA JAMES E; THOMPSON RICHARD C; WILKIE STEPHEN C; BRITTON THOMAS C; PORTER WARREN J; HUFFMAN GEORGE W; LATIMER LEE H
权利人:ELAN PHARM INC; LILLY CO ELI
摘要:Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

专利号:US-6509331-B1
优先权日:1998-06-22
标题:Deoxyamino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
发明人：AUDIA JAMES E; THOMPSON RICHARD C; WILKIE STEPHEN C; BRITTON THOMAS C; PORTER WARREN J; HUFFMAN GEORGE W; LATIMER LEE H
权利人:ELAN PHARM INC; LILLY CO ELI
摘要:Disclosed are compounds which inhibit beta-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits beta-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

专利号:US-6696438-B2
优先权日:1998-06-22
标题:Cyclic amino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
发明人：AUDIA JAMES E; DRESSMAN BRUCE A; SHI QING
权利人:ELAN PHARM INC; LILLY CO ELI
摘要:Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

专利号:US-7390801-B2
优先权日:1996-12-23
标题:Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
发明人：THORSETT EUGENE D; PLEISS MICHAEL A; LATIMER LEE H; JOHN VARGHESE; FREEDMAN STEPHEN; BRITTON THOMAS C; AUDIA JAMES A; REEL JON K; DRESSMAN BRUCE A; DROSTE JAMES J; HENRY STEVEN S; STUCKY RUSSELL D; PORTER WARREN J
权利人:ATHENA NEUROSCIENCES INC; LILLY CO ELI
摘要:Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.