CAS: 656-64-4; 3-Bromo-4-Fluoroaniline

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CAS号1007-16-5 3-溴-4-氟苯甲酸 | CAS号701-45-1 2-溴-1-氟-4-硝基苯 | CAS号7758-19-2 亚氯酸钠 | CAS号77771-02-9 3-溴-4-氟苯甲醛 | CAS号1072-85-1 1-溴-2-氟苯 | CAS号452-62-0 3-溴-4-氟甲苯 | CAS号13194-71-3 2-溴-4-甲基苯胺盐酸盐 | CAS号811842-30-5 3-溴-4-氟碘苯 | CAS号836619-77-3 N-B°C-3-溴-4-氟苯胺 | CAS号77123-60-5 3-乙炔基-4-氟苯胺 | CAS号1160789-91-2 5-溴-6-氟苯并[d]噻唑-2-胺 | CAS号710351-24-9 3-BROMO-4-FLUOR... | CAS号890129-90-5 3-环丙基-4-氟苯胺 | CAS号937816-89-2 1-(2-氨基-4-溴-5-氟...

3-溴-4-氟苯甲酸置于三(2-氯乙基)胺,硫酸体系中,化学反应生成 3-溴-4-氟苯胺
参考文献:The Orton Rearrangement In Aprotic Solvents. Some Observations On The Reactions Of P-Substituted N-Bromoacylanilides In Chlorobenzene And Trichloroacetic Acid
标题:The Orton Rearrangement In Aprotic Solvents. Some Observations On The Reactions Of P-Substituted N-Bromoacylanilides In Chlorobenzene And Trichloroacetic Acid
摘要:一系列对位取代的n-溴代苯甲酰胺在氯苦基甲酸三氯乙酸处理时的定性和动力学行为已经研究.先前对邻硝基衍生物展示的异常反应已被证明也发生在对位异构体上.讨论了正常和异常反应的机制.描述了一些4-氟-3-溴苯胺的衍生物.
DOI:10.1139/v60-331

专利信息

专利号:US-9873688-B2
优先权日:2013-11-08
标 题:Process for the synthesis of an indoleamine 2,3-dioxygenase inhibitor
发明人：TAO MING; FRIETZE WILLIAM; MELONI DAVID J; WENG LINGKAI; ZHOU JIACHENG; PAN YONGCHUN
权利人:INCYTE CORP; INCYTE HOLDINGS CORP
摘要:The present application is directed to processes and intermediates for making 4-({2-[(aminosulfonyl)amino]ethyl}amino)-N-(3-bromo-4-fluorophenyl)-N′-hydroxy-1,2,5-oxadiazole-3-carboximidamide, which is an inhibitor of indoleamine 2,3-dioxygenase, useful in the treatment of cancer and other disorders.

专利号:EP-3744715-A1
优先权日:2013-11-08
标题:Process for the synthesis of an indoleamine 2,3-dioxygenase inhibitor

专利号:TW-202309014-A
优先权日:2013-11-08
标题 :Process for the synthesis of an indoleamine 2,3-dioxygenase inhibitor

专利号:US-2018244663-A1
优先权日:2013-11-08
标 题:Process for the synthesis of an indoleamine 2,3-dioxygenase inhibitor

专利号:TW-202100523-A
优先权日:2013-11-08
标题:Process for the synthesis of an indoleamine 2,3-dioxygenase inhibitor

专利号:EP-3066085-B1
优先权日:2013-11-08
标题:Process for the synthesis of an indoleamine 2,3-dioxygenase inhibitor