CAS: 72657-23-9; (R)-Methyl 3-Hydroxy-2-Methylpropanoate

相似化合物

80657-57-4 42998-03-8 1910-47-0

上下游产品

diazomethane 3-hydroxyisobutyric acid (R)-3-hydroxy-2-methyl propionic acid methyl 2-hydroxymethylacrylate (2R)-3-benzyloxymethoxy-2-methylpropionic acid methyl ester 3-Benzyloxy-N-methoxy-2,N-dimethyl-propionamide (S)-3-benzyloxy-2-methylpropan-1-ol (R)-3-bromo-2-methylpropionic acid methyl ester

2-(羟甲基)丙烯酸甲酯置于glucose Dehydrogenase,Potassium Phosphate,葡萄糖,Ene Reductase Yqjm Wild Type Enzyme,还原型辅酶ii(Nadph)四钠盐体系中,用 2-甲基四氢呋喃,Aq. Phosphate Buffer 作为反应溶剂,以58%的收率获得产物(-)-甲基-D-Bata-羟基异丁酸酯
参考文献:寻找选择性开关-对烯还原酶yqjm立体互补变体的一种合理方法
标题:寻找选择性开关-对烯还原酶yqjm立体互补变体的一种合理方法
摘要:来自old Yellow Enzyme家族的烯还原酶是通用的生物催化剂,可用于合成旋光化合物.与化学合成中的竞争性催化剂相比,生物催化剂的一个缺点是通常只有一种产品的立体异构体可用.另一个缺点可能是某些酶-底物组合缺乏活性.在3-羟基-2-甲基丙酸甲酯的酶促合成中,我们能够合理地应对这两个挑战(通常称为罗氏烯还原酶yqjm.通过设计yqjm和工程底物突变体的高效,基于概念的方法,我们可以改变反应的速率常数和对映选择性.用成功的突变体已经进行了制备规模的反应.此外,对底物的反复修饰对罗氏酯前体及其衍生物的结合方式提供了基于实验的见解.
DOI:10.1002/adsc.201500149

专利信息

专利号:US-7348436-B2
优先权日:2004-03-02
标题 :Compounds useful for the synthesis of (+)-discodermolide and methods thereof
发明人：MYLES DAVID C; SHAW SIMON JAMES; SUNDERMANN KURT F
权利人:KOSAN BIOSCIENCES INC
摘要:Compounds and methods useful for the synthesis of (+)-discodermolide, a naturally occurring microtubule stabilizing agent useful as an anti-cancer agent.

专利号:US-6384228-B2
优先权日:1998-05-26
标题 :Method for synthesis of halopyridyl-azacyclopentane derivative and intermediate thereof
发明人：NODE MANABU; NAKAMURA DAISAKU; FUJIWARA TOSHIO; ICHIHASHI SHOGO
权利人:NIHON MEDIPHYSICS CO LTD
摘要:The present invention relates to a method for synthesis of an optically active halopyridyl-azacyclo-pentane derivative and the intermediate thereof which comprises preparing an optically active allene-1,3-dicarboxylic acid ester derivative from an optically active acetonedicarboxylic acid ester derivative and then proceeding through a 7-azabicyclo[2.2.1]heptane derivative to obtain the objective product.

专利号:US-7339066-B1
优先权日:2006-05-31
标题 :Intermediates for the synthesis of polypropionate antibiotics
发明人：PARKER KATHLYN; CAO HUANYAN
权利人:UNIV NEW YORK STATE RES FOUND
摘要:The invention relates to intermediate compounds of the formula n nwherein R 1 is H or a protecting group, R 2 and R 3 each independently represent H, methyl, or a leaving group, provided that at least one, but not both, of R 2 and R 3 is a leaving group. The intermediate compounds are useful for the synthesis of discodermolide, its derivatives, and related compounds.

专利号:US-7982054-B2
优先权日:2006-11-08
标题:Process for the synthesis of N-[3-[(2-methoxyphenyl] sulfanyl] -2-methylpropyl] -3,4-dihydro-2H-1,5-benzoxathiepin-3-amine
发明人：VACHER BERNARD; BRUNEL YVES; MAUREL JEAN-LOUIS
权利人:PF MEDICAMENT
摘要:The invention relates to a new process for the preparation of N-[3-[(2-methoxyphenyl)sulfanyl]-2-methylpropyl]-3,4-dihydro-2H-1,5-benzoxathiepin-3-amine.

专利号:US-2024109832-A1
优先权日:2020-11-11
标题:Rapid construction of tetralin, chromane, and indane motifs via cyclative c-h/c-h coupling: four-step total synthesis of (±)-russujaponol f
发明人：YU JIN-QUAN; ZHUANG ZHE
权利人:SCRIPPS RESEARCH INST
摘要:Disclosed herein is a process for achieving a palladium-catalyzed cyclative C(sp3)-H/C(sp2)-H coupling reaction using a native free carboxylic acid as a directing group, an amino acid ligand, and oxidant. The process is useful for synthesizing a range of biologically important scaffolds, including tetralins, chromanes, and indanes.

专利号:US-7884128-B2
优先权日:2005-10-13
标题:Process for total synthesis of pladienolide B and pladienolide D
发明人：KANADA REGINA MIKIE; ITO DAISUKE; SAKAI TAKASHI; ASAI NAOKI; KOTAKE YOSHIHIKO; NIIJIMA JUN
权利人:EISAI R&D MAN CO LTD
摘要:Process for producing compound of Formula: n nwherein P 2 , P 3 and R 2 are the same as defined below, characterized by comprising reacting a compound represented by Formula (7):n n nwherein P 3 means a protecting group for hydroxy group; and Het means a 1-phenyl-1H-tetrazol-5-yl group, with a compound represented by Formula (8):n n nwherein P 2 means a protecting group for hydroxy group; and R 2 means a phenyl group which may be substituted, in the presence of a base.