CAS: 105601-04-5; 3-(1-(Dimethylamino)Ethyl)Phenol

相似化合物

139306-10-8 851086-95-8 5441-61-2

上下游产品

CAS号50-00-0 甲醛 | CAS号63720-38-7 3-(1-氨基乙基)苯酚 | CAS号923035-06-7 3-[1-(methylami... | CAS号5441-61-2 Phenol,3-[1-(di... | CAS号58114-05-9 1-(1-chloroethy... | CAS号591-31-1 3-甲氧基苯甲醛 | CAS号105601-20-5 3-(1-(二甲基氨基)乙基)... | CAS号851086-95-8 3-[(1R)-1-(二甲基氨... | CAS号139306-10-8 3-(1-(S)-(N,N-二...

1-(3-羟基苯基)乙醇置于氯化亚砜,Potassium Carbonate,Potassium Iodide,Potassium Hydroxide体系中,用 二氯甲烷,N,N-二甲基甲酰胺,乙腈 用作溶剂,化学反应 4.5H,反应生成3-[1-(二甲基氨基)乙基]苯酚
参考文献:2,4-双取代苯乙酮化合物及其旋光异构体,药 学上可接受的盐及应用
标题:2,4-双取代苯乙酮化合物及其旋光异构体,药 学上可接受的盐及应用
摘要:本发明涉及一种2,4‑双取代苯乙酮化合物及其旋光异构体,药学上可接受的盐.本发明还公开了2,4‑双取代苯乙酮化合物及其旋光异构体,药学上可接受的盐在治疗神经变性疾病方面的应用,该类新化合物不仅具有乙酰胆碱酯酶抑制活性和aβ聚集抑制能力,其水解产物还具有金属离子螯合作用,可以从多个靶点进行治疗,具有较好的神经变性疾病应用前景.

专利信息

专利号:US-8932838-B2
优先权日:2010-06-17
标 题 :Biocatalysts and methods for the synthesis of (S)-3-(1-aminoethyl)-phenol
发明人：CABIROL FABIEN LOUIS; GOHEL ANUPAM; OH SEONG HO; SMITH DEREK J; WONG BRIAN; LALONDE JAMES J
权利人:CODEXIS INC
摘要:The present disclosure provides engineered transaminase polypeptides having improved properties as compared to naturally occurring transaminases including the ability of converting the substrate, 3′-hydroxyacetophenone to (S)-3-(1-aminoethyl)-phenol in enantiomeric excess and high percentage conversion. Also provided are polynucleotides encoding the engineered transaminases, host cells capable of expressing the engineered transaminases, and methods of using the engineered transaminases to synthesize (S)-3-(1-aminoethyl)-phenol and related compounds useful in the production of active pharmaceutical ingredients.

专利号:US-10882819-B2
优先权日:2018-09-26
标 题 :Synthesis of novel intermediate(s) for preparing rivastigmine
发明人：YADAV JHILLU SINGH; EPPA GYANCHANDER; VACHHARAJANI PRANAV RAMESHBHAI; VEKARIYA NUTAN BHARATBHAI; BHAVSAR CHETAN UMESHBHAI; MODI RAJIV INDRAVADAN; KHAMAR BAKULESH MAFATLAL
权利人:CADILA PHARMACEUTICALS LTD; CADILA CORP CAMPUS
摘要:The present invention relates to novel intermediate(s), which are useful for the preparation of Rivastigmine compound of formula (I) and its pharmaceutically acceptable salts. The present invention further relates to the processes for the preparation of such novel intermediate(s) and preparation of Rivastigmine using such novel intermediate(s).

专利号:US-2010256229-A1
优先权日:2009-04-02
标题:Compositions of cholinesterase inhibitors
发明人：DU SHOUCHENG; ANDERSEN MARC W; COUGHLIN DANIEL; KOLCHINSKI ALEXANDER
权利人:COLUCID PHARMACEUTICALS INC
摘要:The present invention is directed to compositions, methods of use, and processes for the synthesis related to 3-((S)-1-(dimethylamino)ethyl)phenyl methyl-((R)-1-phenylpropan-2 yl)carbamate, and its pharmaceutically acceptable salt forms, including the hydrogen fumarate salt. The present invention also relates to a novel form polymorph of 3-((S)-1-(dimethylamino)ethyl)phenylmethyl-((R)-1-phenylpropan-2 yl)carbamate, characterized by a unique X-ray diffraction pattern and Differential Scanning Calorimetry profile, as well a unique crystalline structure.

专利号:US-2020095195-A1
优先权日:2018-09-26
标 题:Synthesis of novel intermediate(s) for preparing rivastigmine

专利号:US-2013089898-A1
优先权日:2010-06-17
标 题:Biocatalysts and methods for the synthesis of (s)-3-(1-aminoethyl)-phenol

专利号:US-2014356944-A1
优先权日:2010-06-17
标 题:Biocatalysts and methods for the synthesis of (s)-3-(1-aminoethyl)-phenol