CAS: 136030-00-7; (1R,2S)-1-Amino-2,3-Dihydro-1H-Inden-2-Ol

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CAS号7480-35-5 顺式-1-氨基-2,3-二氢-... | CAS号180186-94-1 (+)-2,2'-亚甲基双[(... | CAS号766556-66-5 6-甲氧基吲哚-3-甲酸

(1R,2R)-2-Acetoxy-1-Azidoindan置于palladium On Activated Charcoal 氢气,Sodium Methylate,Potassium Carbonate,三苯基膦,偶氮二甲酸二乙酯体系中,用 四氢呋喃,甲醇,乙醇 用作溶剂,25.0 °C,100.0 Kpa 条件下,反应 8.0H,反应生成(1R,2S)-1-氨基-2-茚醇
参考文献:Lipase-Mediated Resolution Of Trans-1-Azidoindan-2-Ol: A New Route To Optically Pure Cis-1-Aminoindan-2-Ol
标题:Lipase-Mediated Resolution Of Trans-1-Azidoindan-2-Ol: A New Route To Optically Pure Cis-1-Aminoindan-2-Ol
摘要:通过在有机溶剂中经由脂肪酶介导的动力学转酯化反应,已经制备得到了具有光学纯度的反式-1-叠氮茚-2-醇两种对映异构体.此外,还开发了一种利用上述所得光学纯度叠氮醇来制备具有光学纯度的顺式-1-氨基茚-2-醇的方法.
Doi:10.1055/s-1996-4328

专利信息

专利号:US-7452994-B2
优先权日:2001-09-12
标 题 :Synthesis of enantiomerically pure amino-substituted fused bicyclic rings
发明人：MCEACHERN ERNEST J; BRIDGER GARY J; SKUPINSKA KRYSTYNA A; SKERLJ RENATO T; YANG WEN
权利人:ANORMED INC
摘要:This invention describes various processes for synthesis and resolution of racemic amino-substituted fused bicyclic ring systems. One process utilizes selective hydrogenation of an amino-substituted fused bicyclic aromatic ring system. An alternative process prepares the racemic amino-substituted fused bicyclic ring system via nitrosation. In addition, the present invention describes the enzymatic resolution of a racemic mixture to produce the (R)- and (S)-forms of amino-substituted fused bicyclic rings as well as a racemization process to recycle the unpreferred enantioner. Further provided by this invention is an asymmetric synthesis of the (R)- or (S)-enantiomer of primary amino-substituted fused bicyclic ring systems.

专利号:US-2013150622-A1
优先权日:2011-12-12
标题:Stereoselective synthesis of tapentadol and its salts
发明人：FANDRICK DANIEL ROBERT; RODRIGUEZ SONIA; YANG BING-SHIOU
权利人:BOEHRINGER INGELHEIM INT; BOEHRINGER INGELHEIM INT
摘要:A process for the synthesis of a salt of tapentadol.

专利号:EP-1730108-B1
优先权日:2004-03-18
标 题:Stereoselective synthesis of vitamin d analogues
发明人：SABROE THOMAS PETER; CALVERLEY MARTIN JOHN
权利人:LEO PHARMA AS
摘要:The present invention relates to intermediates useful for the synthesis of calcipotriol or calcipotriol monohydrate, to methods of producing said intermediates, and to methods of stereoselectively reducing said intermediates.

专利号:EP-1735276-B1
优先权日:2004-04-02
标题:Novel method for the preparation of intermediates useful for the synthesis of vitamin d analogues
发明人：HANSEN ERIK TORNGAARD; SABROE THOMAS PETER; CALVERLEY MARTIN JOHN; PEDERSEN HENRIK; DEUSSEN HEINZ-JOSEF WILHELM
权利人:LEO PHARMA AS
摘要:The present invention relates to novel methods for the preparation of intermediates which are useful in the synthesis of cacipotriol. The present invention relates further to the use of intermediates produced with said methods for making calcipotriol or calcipotriol monohydrate.

专利号:EP-2280974-B1
优先权日:2008-04-30
标题:Stereoselective synthesis of certain trifluoromethyl-substituted alcohols
发明人：REEVES JONATHAN TIMOTHY; SONG JINHUA J; TAN ZHULIN
权利人:BOEHRINGER INGELHEIM INT; BOEHRINGER INGELHEIM PHARMA
摘要:A process for stereoselective synthesis of a compound of Formula (I) wherein R1, R2, R3, R4, and R5 are as described herein.

专利号:US-8759555-B2
优先权日:2004-03-18
标 题:Stereoselective synthesis of vitamin D analogues
发明人：SABROE THOMAS PETER; CALVERLEY MARTIN JOHN
权利人:SABROE THOMAS PETER; CALVERLEY MARTIN JOHN; LEO PHARMA AS
摘要:The present invention relates to intermediates useful for the synthesis of calcipotriol or calcipotriol monohydrate, to methods of producing said intermediates, and to methods of stereoselectively reducing said intermediates.