CAS: 20532-33-6; 5-Chlorobenzothiophene

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CAS号50548-46-4 1-Chloro-4-[(2,... | CAS号118743-10-5 (4-chlorophenyl... | CAS号13771-75-0 5-氯-1-苯并噻吩-2-羧酸 | CAS号106-54-7 4-氯苯硫酚 | CAS号110-81-6 二乙基二硫 | CAS号106-46-7 1,4-二氯苯 | CAS号32969-26-9 3-溴-5-氯苯并[b]噻吩 | CAS号20532-30-3 5-甲氧基苯并噻吩 | CAS号20532-28-9 5-氨基苯并噻吩 | CAS号2060-63-1 1-苯并噻吩-5-腈 | CAS号28540-51-4 5-氯苯并[b]噻吩-2-羧醛 | CAS号2060-64-2 1-苯并噻吩-5-羧酸 | CAS号128851-98-9 5-Chlorobenzo[b... | CAS号13771-75-0 5-氯-1-苯并噻吩-2-羧酸

5-氯-1-苯并噻吩-2-羧酸置于喹啉,铜体系中,化学反应 0.5H,以18%的收率获得5-氯苯并噻吩
参考文献:新的5-取代的苯并[ B ]噻吩衍生物的合成
标题:新的5-取代的苯并[ B ]噻吩衍生物的合成
摘要:我们小组以前的工作涉及1-(芳基)-3-[4-(芳基)哌嗪-1-基]丙烷衍生物的合成,以寻找具有双重作用方式的新型高效抗抑郁药:5-羟色胺再摄取抑制和5-Ht 1A受体的亲和力[1-4].从这些研究中我们得出结论,3-[4-(芳基)哌嗪-1-基]-1-(苯并[ B ]噻吩-3-基)丙烷衍生物导致了最佳结果.该研究项目的继续,需要制备一些新的3-酰基-5-取代的苯并[ B ]噻吩,其在5位上具有广泛的取代基,范围从硝基到羟基衍生物.为了获得这些衍生物,我们尽可能地将相应的5-取代的苯并[ B ]噻吩酰化.
Doi:10.1002/jhet.5570380502

专利信息

专利号:WO-9427985-A1
优先权日:1993-05-28
标题 :Process for the preparation of substituted 3-halomethyl-benzothiophenes, benzofurans and -indoles and intermediates thereof
发明人：PRIDGEN LENDON NORWOOD
权利人:SMITHKLINE BEECHAM CORP; PRIDGEN LENDON NORWOOD
摘要:This invention relates to novel intermediates and processes for preparing useful intermediates of formula (I) which are useful in the synthesis of pharmaceutically active agents.

专利号:US-2005192265-A1
优先权日:2003-03-20
标 题:Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting beta-amyloid peptide release and/or its synthesis by use of such compounds
发明人：THOMPSON RICHARD C; WILKIE STEPHEN; STACK DOUGLAS R; VANMETER ELDON E; SHI QING; BRITTON THOMAS C; AUDIA JAMES E; REEL JON K; MABRY THOMAS E; DRESSMAN BRUCE A; CWI CYNTHIA L; HENRY STEVEN S; MCDANIEL STACEY L; STUCKY RUSSELL D; PORTER WARREN J
摘要:Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions that include a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

专利号:WO-9967219-A1
优先权日:1998-06-22
标 题:Compounds for inhibiting beta-amyloid peptide release and/or its synthesis
发明人：AUDIA JAMES E; PORTER WARREN J; THOMPSON RICHARD C; WILKIE STEPHEN C; STACK DOUGLAS R; SHI QING
权利人:ELAN PHARM INC; LILLY CO ELI; AUDIA JAMES E; PORTER WARREN J; THOMPSON RICHARD C; WILKIE STEPHEN C; STACK DOUGLAS R; SHI QING
摘要:Compounds of formula (I), wherein W is a cyclic group of the type (2); (3); Y is represented by the formula (II); these compounds inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

专利号:WO-9966934-A1
优先权日:1998-06-22
标 题 :CYCLIC AMINO ACID COMPOUNDS, PHARMACEUTICAL COMPOSITIONS COMPRISING SAME, AND METHODS FOR INHIBITING β-AMYLOID PEPTIDE RELEASE AND/OR ITS SYNTHESIS BY USE OF SUCH COMPOUNDS
发明人：AUDIA JAMES E; DRESSMAN BRUCE A; SHI QING
权利人:ELAN PHARM INC; LILLY CO ELI; AUDIA JAMES E; DRESSMAN BRUCE A; SHI QING
摘要:Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

专利号:US-6774125-B2
优先权日:1998-06-22
标 题:Deoxyamino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
发明人：AUDIA JAMES E; THOMPSON RICHARD C; WILKIE STEPHEN C; BRITTON THOMAS C; PORTER WARREN J; HUFFMAN GEORGE W; LATIMER LEE H
权利人:ELAN PHARM INC; LILLY CO ELI
摘要:Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

专利号:US-6509331-B1
优先权日:1998-06-22
标题:Deoxyamino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
发明人：AUDIA JAMES E; THOMPSON RICHARD C; WILKIE STEPHEN C; BRITTON THOMAS C; PORTER WARREN J; HUFFMAN GEORGE W; LATIMER LEE H
权利人:ELAN PHARM INC; LILLY CO ELI
摘要:Disclosed are compounds which inhibit beta-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits beta-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.