CAS: 25503-90-6; 1-Acetylpiperidine-4-Carboxylic Acid

相似化合物

126501-70-0 155826-26-9 846057-27-0

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CAS号498-94-2 4-哌啶甲酸 | CAS号108-24-7 乙酸酐 | CAS号108-10-1 甲基异丁基甲酮 | CAS号3874-54-2 4-氯-4'-氟苯丁酮 | CAS号37586-22-4 苯基(哌啶-4-基)甲酮 | CAS号53220-41-0 4-(4-氯苯甲酰基)哌啶 | CAS号92822-02-1 4-(4'-氟苄基)哌啶 | CAS号25519-77-1 1-[4-(2,4-二氟苯甲酰... | CAS号84162-82-3 1-(4-(2,4-二氟苯甲酰... | CAS号25519-79-3 1-(4-苯甲酰基-1-哌啶)-乙酮 | CAS号59084-16-1 N-乙酰基哌啶-4-酰氯 | CAS号56346-57-7 4-(4-氟苯甲酰基)哌啶 | CAS号126291-66-5 1-Acetyl-piperi... | CAS号209808-06-0 1-B°C-4-(4-氯苯甲酰)哌啶

4-哌啶甲酸 反应生成1-乙酰基-4-哌啶甲酸
参考文献:Therapeutically Useful 1-Phenyl-2-Piperidinoalkanol Derivatives
标题:Therapeutically Useful 1-Phenyl-2-Piperidinoalkanol Derivatives
摘要:公式为:##str1## 的化合物,其中r.Sub.1为氢,卤素,三氟甲基,烷基,羟基,烷氧基,苄氧基,脂肪酰氧基或苯甲酰氧基,或当r.Sub.2为4-位上的羟基或甲氧基,R.Sub.3为氢时,R.Sub.1也可以表示羟甲基氨基甲酰或烷氧羰基,R.Sub.2为氢,卤素,烷基,羟基或烷氧基,R.Sub.3为氢或烷基,R.Sub.4为烷基(在这种情况下,化合物为(+/-)-Erythro),或当r.Sub.3表示氢时,R.Sub.4也可以为氢,R.Sub.5为氢,卤素,烷基,烷氧基或3-,4-和5-位置上的三个甲氧基团,并且其药学上可接受的酸盐,但排除其中:(A) R.Sub.1和r.Sub.2中的一个在4-位上,为羟基,烷氧基或苄氧基,另一个在3-位上,为氢,羟基,烷氧基或苄氧基,R.Sub.3和r.Sub.5为氢的化合物; (B) R.Sub.1在4-位上为卤素,R.Sub.4为甲基,R.Sub.2,R.Sub.3和r.Sub.5为氢的化合物,可用作药物.

专利信息

专利号:US-8703747-B2
优先权日:2008-07-23
标题 :Aminophosphinic derivatives that can be used in the treatment of pain
发明人：ROQUES BERNARD; PORAS HERVÉ; FOURNIE-ZALUSKI MARIE-CLAUDE
权利人:ROQUES BERNARD; PORAS HERVÉ; FOURNIE-ZALUSKI MARIE-CLAUDE; PHARMALEADS
摘要:The present invention relates to a compound of the following general formula (I): R 1 —NH—CH(R 2 )—P(â•?O)(OR 3 )—CH 2 —C(R 4 )(R 5 )—CONH—CH(R 6 )—COOR 7 (I) or a pharmaceutically acceptable salt of the latter, an isomer or a mixture of isomers in any proportions, especially a mixture of enantiomers, and in particular a racemic mixture, for which R 1 represents a —C(â•?O)—O—C(R 8 )(R 9 )—OC(â•?O)—R 10 group; R 2 represents an optionally substituted hydrocarbon-based chain, an aryl or heteroaryl group or a methylene group substituted by a heterocycle; R 3 represents a hydrogen atom or a —C(R 12 )(R 13 )—OC(â•?O)—R 14 group; R 4 and R 5 form, together with the carbon that bears them, a saturated hydrocarbon-based ring or an optionally substituted piperidine ring or R 4 represents a hydrogen atom and R 5 represents a phenyl or a benzyl that is optionally substituted, a heteroaromatic ring or a methylene group substituted by a heterocycle; R 6 represents an optionally substituted hydrocarbon-based chain or a phenyl or a benzyl that is optionally substituted; and R 7 represents a hydrogen atom or a benzyl, alkyl, heteroaryl, alkylheteroaryl, —CHMe—COOR 18 , —CHR 19 —OC(â•?O)OR 20 and —CHR 19 —OC(â•?O)OR 20 group. The present invention also relates to the use of these compounds as a medicinal product, and in particular for the treatment of pain, more avantageously neuropathic and neuroinflammatory pain, to their method of synthesis and also to the compositions containing them.

专利号:EP-3515880-B1
优先权日:2017-03-17
标题:Methods and compositions for synthesis of encoded libraries
发明人：LI JIN; MORGAN BARRY A; Wan jinqiao; DOU DENGFENG; LIU GUANSAI; CHANG YONG; CHEN QIUXIA; WANG XING; XU YANSHAN; HU DONGYAN; LIU JIAN; CHENG XUEMIN
权利人:HITGEN INC

专利号:US-2020149034-A1
优先权日:2017-03-17
标题:Methods and Compositions for Synthesis of Encoded Libraries

专利号:US-7049441-B2
优先权日:2001-01-18
标 题 :Process for preparation of benzylpiperidine compounds
发明人：MIKI SHOKYO; TAKEDA MITSUHIRO; NAKAMOTO KOJI
权利人:TAKEDA PHARMACEUTICAL
摘要:According to the process as shown in the following scheme having a step for reacting Compound (I) with Compound (II) to produce Compound (III), benzylpiperidine compounds useful as synthesis starting materials of pharmaceutical agents, agricultural chemicals and the like can be produced conveniently by a short step: n nwherein R 1 is a hydrogen atom or an amino-protecting group, R 2 is a hydrogen atom, a hydrocarbon group optionally having substituents, an alkoxy group optionally having substituents or a heterocyclic group optionally having substituents, and R 3 is a lower alkyl group.

专利号:RU-2083580-C1
优先权日:1991-08-23
标题 :1,7-anular derivatives of 3-(piperazinoalkyl)-indole, method of their synthesis (variants), pharmaceutical composition containing thereof and an intermediate compound for their synthesis

专利号:US-2006211603-A1
优先权日:2004-08-18
标 题:Ramoplanin derivatives possessing antibacterial activity
发明人：RAJU BORE G; CIABATTI ROMEO; MAFFIOLI SONIA I; SINGH UPINDER; ROMANO GABRIELLA; MICHELUCCI ELENA; TISENI PAOLO S; CANDIANI GIANPAOLO; KIM BUM; O'DOWD HARDWIN
权利人:VICURON PHARM INC
摘要:Novel ramoplanin derivatives are disclosed. These ramoplanin derivatives exhibit antibacterial activity. As the compounds of the subject invention exhibit potent activities against gram positive bacteria, they are useful antimicrobial agents. Methods of synthesis and of use of the compounds are also disclosed.