1,3-二氟苯置于溴体系中,用 二氯甲烷 用作溶剂,化学反应 2.0H,以99%的收率获得1-溴-2,4-二氟苯 参考文献:溴化 的 芳香族化合物使用fe 2 O 3 /沸石 催化剂 标题:溴化 的 芳香族化合物使用fe 2 O 3 /沸石 催化剂 摘要:催化性 溴化 未激活 芳香族化合物使用fe 2 O 3 /沸石催化剂体系.Febr 3被确定为由hbr和fe 2 O 3原位形成的催化物质.这催化剂易于处理且具有成本效益,也可以回收利用.反应系统也适合一锅法溴化/ Cc键的形成 苯. Doi:10.1039/c2Gc35821B
专利信息
专利号:WO-2013091696-A1 优先权日:2011-12-21 标题 :Synthesis of intermediates for preparing anacetrapib and derivatives thereof 发明人:HUMLJAN JAN; MARAS NENAD 权利人:LEK PHARMACEUTICALS; HUMLJAN JAN; MARAS NENAD 摘要:The present invention relates to the field of organic chemistry, more specifically to the synthesis of intermediate compounds which can be used in the synthesis of pharmaceutically active agents such as anacetrapib or derivatives thereof.
专利号:EP-2468735-A1 优先权日:2010-12-23 标 题:Synthesis of intermediates for preparing anacetrapib and derivates thereof 权利人:LEK PHARMACEUTICALS 摘要:The present invention relates to the field of organic chemistry, more specifically to the synthesis of intermediate compounds which can be used in the synthesis of pharmaceutically active agents such as anacetrapib or derivatives thereof.
专利号:US-9212118-B2 优先权日:2010-12-23 标题:Synthesis of intermediates for preparing anacetrapib and derivatives thereof 发明人:HUMLJAN JAN; MARAS NENAD 权利人:HUMLJAN JAN; MARAS NENAD; LEK PHARMACEUTICALS 摘要:The present invention relates to the field of organic chemistry, more specifically to the synthesis of intermediate compounds which can be used in the synthesis of pharmaceutically active agents such as anacetrapib or derivatives thereof.
专利号:US-5349099-A 优先权日:1993-12-13 标题:Process for preparing intermediates for the synthesis of antifungal agents 发明人:KUO SHEN-CHUN; HOU DONALD; ZHAN ZHENG-YUN 权利人:SCHERING CORP 摘要:Disclosed is a process for preparing allylic halides of the formula I ##STR1## wherein X is Cl, Br or I, for use as intermediates in the synthesis of substituted tetrahydrofuran azole anti-fungal agents.
专利号:US-2024101516-A1 优先权日:2021-01-20 标 题:Synthesis of polyfluorinated aryl and heteroaryl carboxamides 发明人:KADUSKAR RAHUL; BORATE KAILASKUMAR; ADHAV SUYOG; THIRUNAVUKKARASU SARAVANAN; SHINDE HARISH; GOETZ ROLAND 权利人:BASF SE 摘要:The presently claimed invention relates to a process for the preparation of mono-, di-, tri-, fluoro arylamide or hetroarylamide.
专利号:WO-2004050654-A1 优先权日:2002-11-29 标 题 :Synthesis of pyrrolidine compound and salt thereof 发明人:KAWANISHI YASUYUKI; UENAKA MASAAKI; IDE YUTAKA; SHINOMOTO SHOJI; OKUNO TAKAYUKI 权利人:SHIONOGI & CO; KAWANISHI YASUYUKI; UENAKA MASAAKI; IDE YUTAKA; SHINOMOTO SHOJI; OKUNO TAKAYUKI 摘要:A p-toluenesulfonate, sulfate, or hydrochloride of the compound represented by the formula (I): (I) a solvate of any of these, or crystals of any of these; and processes for producing these.
[参考文献]: Ram Shankar Upadhayaya, Et Al. Optically Active Antifungal Azoles: Synthesis And Antifungal Activity Of (2R,3S)-2-(2,4-Difluorophenyl)-3-(5-[2-[4-Aryl-Piperazin-1-Yl]-Ethyl]-Tetrazol-2-Yl/1-Yl)-1-[1,2,4]-Triazol-1-Yl-Butan-2-Ol. Bioorg Med Chem. 2004 May 1;12(9):2225-38.
合成参考文献
摘要:Amatore, M.; Aubert, C.; Malacria, M.; Petit, M., Science of Synthesis Knowledge Updates, (2012) 3, 48. 摘要:Lubell, W. D.; St-Cyr, D. J.; Dufour-Gallant, J.; Hopewell, R.; Boutard, N.; Kassem, T.; Dörr, A.; Zelli, R., Science of Synthesis Knowledge Updates, (2013) 1, 309. 摘要:Dong, X.; Liu , H., Science of Synthesis Knowledge Updates, (2019) 3, . 摘要:Rudzinski, D. M.; Leadbeater, N. E., Science of Synthesis Knowledge Updates, (2012) 1, 374. 摘要:Ouali, A.; Taillefer, M., Science of Synthesis: C-1 Building Blocks in Organic Synthesis, (2013) 2, 108.