专利号:US-6861531-B2 优先权日:2002-03-27 标 题:Synthesis of 2,6-dicarbonylpyridines 发明人:GATELY DANIEL A 权利人:BOULDER SCIENT CO 摘要:Synthesis of 2,6-dicarbonylpyridines in solution in a hydrocarbon medium is described. The solutions of 2,6-dicarbonylpyridines may be used directly in further syntheses.
专利号:US-2005239808-A1 优先权日:2002-05-10 标题 :Active substances for the treatment, diagnosis and prophylaxis of diseases in which abnormal protein structures occur 发明人:SCHRADER THOMAS; RIESNER DETLEV; RZEPECKI PETRA; NAGEL-STEGER LUITGARD; WEHNER MARK; KIRSTEN CHRISTIAN; MOLT OLIVER; ZADMARD REZA; ASCHERMANN KATJA 权利人:SCHRADER THOMAS; RIESNER DETLEV; RZEPECKI PETRA; NAGEL-STEGER LUITGARD; WEHNER MARK; KIRSTEN CHRISTIAN; MOLT OLIVER; ZADMARD REZA; ASCHERMANN KATJA 摘要:The invention on hand refers to diseases associated with abnormal protein structures, including Alzheimer's disease, Creutzfeldt-Jakob's disease, BSE and other prion-associated diseases. It is the task of the invention on hand to provide new active agents preventing the formation of amyloid plaques and to dissolve existing plaques, such agents being convenient for therapy, diagnosis and prophylaxis of diseases that are associated with abnormal protein structures. This task is performed in terms of the current invention by heterocyclic or aromatic agents with a rigid structure and a donor-acceptor-donor pattern (DAD), the latter being formed by donors and acceptors of hydrogen bridge linkages which comply with the β-sheet structure of the peptide or protein and thus fit as binding partners. The heterocyclic or aromatic agents are available at least as dimers. They recognise peptides and proteins with a β-sheet structure, form stable complexes with them and inhibit their aggregation to β-amyloid plaques. Furthermore, the new active agents are able to dissolve β-amyloid plaques that already exist. Another task of the current invention is to provide methods for the synthesis of said heterocyclic or aromatic compounds.
专利号:MD-4847-C1 优先权日:2021-09-09 标 题:Tris(2,6-dimethyl pyridinedicarboxylate-1kONO)-di-m-(isothiocyanato-1,2kN)-(diisothiocyanato-2kN)barium(II)cobalt(II) with the properties of a stimulator of the synthesis of biologically active substances in mushrooms
专利号:US-2003187271-A1 优先权日:2002-03-27 标题 :Synthesis of 2, 6-dicarbonylpyridines
专利号:WO-03082824-A1 优先权日:2002-03-27 标 题 :Synthesis of 2,6-dicarbonylpyridines
专利号:CN-106596542-A 优先权日:2016-12-20 标 题 :Synthesis of a UV Fluorescent Molecular Probe and Its Detection of Nitrite
参考文献:10.1134/s1070328422700245 摘要:Bulhac I, Ureche D, Kravtsov V, Bourosh P. Synthesis and Structure of Heterometallic Compounds with Dimethyl Pyridine-2,6-dicarboxylate. Russ J Coord Chem. 2023 Feb;49(2):77–85. doi: 10.1134/s1070328422700245. 参考文献:10.1007/s13738-023-02863-1 摘要:Mukiza J, Habarurema G, Nkuranga JB, Sezirahiga J, Akin-Ojo O, Nkurunziza JB, Kampire E, Gakuba E, Blacque O. Thiocyanate-induced N-activation and nucleophilic 1,2-dearomatization of pyridinedicarbonyl dichloride: a synthetic route to a novel 1,2-dihydropyridine-based heterocyclic compound. J IRAN CHEM SOC. 2023 Aug 02;20(10):2657–64. doi: 10.1007/s13738-023-02863-1. 参考文献:10.1007/978-981-97-4764-1_10 摘要:Khalaf B, Jodeh S, Samhan S. Novel Cellulose-Based Hectocycle Nanopolymers for Arsenic Removal from Groundwater. 2024. In: Arsenic Remediation of Food and Water. 参考文献:10.1007/s00706-025-03288-7 摘要:Cinar S. Synthesis of novel pyridine-bodipy conjugate and investigation of ion recognition properties. Monatsh Chem. 2025 Feb 24;156(3):279–86. doi: 10.1007/s00706-025-03288-7. 参考文献:10.1007/s40843-025-3836-8 摘要:Chen S, Chang L, Zhang G, Xie W, Xiao X. Interface engineering of MXenes for flexible energy storage and harvesting. Sci. China Mater. 2026 Jan 28;69(3):1265–90. doi: 10.1007/s40843-025-3836-8.