专利号:US-2025228878-A1 优先权日:2021-10-14 标题:Method for the synthesis of evoc probes 发明人:ALLSWORTH MAX; LABUSCHAGNE CHRISTIAAN 权利人:OWLSTONE MED LTD 摘要:A process for the synthesis of a glycoside, comprising the step of;n performing hydrolysis of a methyl ester glycoside in the presence of a base in water, to form a glycoside,n nwherein the propensity to reform the methyl ester glycoside is reduced. The invention also extends to methods for the detection or prognosis of cancer using a glycoside obtained by said process
专利号:US-2024209029-A1 优先权日:2021-04-21 标题:Adiponectin glycopeptides and compositions and methods of use thereof 发明人:WANG YU; LI XUECHEN; XU AIMIN; WU HONGXIANG; ZHANG YIWEI; LI YUANXIN 权利人:UNIV HONG KONG 摘要:An improved method for the chemical synthesis of glycosylated peptides has been developed. The method uses stereoselective glycan synthesis and chemical peptide ligation to produce glycopeptides at lower-cost and with higher efficiency/yield compared to conventional methods. In particular, a method for the large-scale, chemical synthesis of hydroxylated amino acid building blocks and glycosylated amino acids suitable for solid phase peptide synthesis (SPPS) are disclosed. SPPS-based methods using the glycosylated amino acids to chemically synthesize adiponectin-like peptides are also described. In vivo studies show that the adiponectin mimicking glycopeptides exhibit significant anticancer, anti-obesity and insulin sensitizing effects. Pharmaceutical compositions of the synthetic glycopeptides and methods of use thereof in treating diseases associated with deficient adiponectin are also described.
专利号:US-3838183-A 优先权日:1971-06-09 标 题:Synthesis of 2-methyl-3-buten-2-ol 发明人:WEHRLI P 权利人:HOFFMANN LA ROCHE 摘要:A PROCESS FOR PRODUCING 2-METHYL-3-BUTEN-2-OL BY REACTING ISOPRENE WITH A HYDROHALIDE AND THEN WITH AN AQUEOUS BASE AND THEN DISTILLING THE AQUEOUS MIXTURE IN THE PRESENCE OF EXCESS BASE TO MAINTAIN THE REACTION MIXTURE DURING DISTILLATION AT A PH OF AT LEAST 4.
专利号:US-8962858-B2 优先权日:2011-01-21 标题 :Methods and compounds useful in the synthesis of fused aminodihydrothiazine derivatives 发明人:MITASEV BRANKO; KIM DAE-SHIK; ZHANG HUIMING; FARTHING CHRISTOPHER N 权利人:EISAI R&D MAN CO LTD 摘要:Provided are compounds and methods useful for the preparation of compounds useful as inhibitors of beta-site amyloid precursor protein (APP)-cleaving enzyme.
专利号:US-5637757-A 优先权日:1995-04-11 标 题 :One-pot synthesis of ring-brominated benzoate compounds 发明人:HILL JOHN E; FAVSTRITSKY NICOLAI A; MAMUZIC RASTKO I; BHATTACHARYA BHABATOSH 权利人:GREAT LAKES CHEMICAL CORP 摘要:A method of preparing tetrabromobenzoate compounds from tetrabromophthalic anhydride by reacting tetrabromophthalic anhydride with alcohol in the presence of a decarboxylation catalyst. The reaction may be carried out in an excess of alcohol, or with a near stoichiometric amount of alcohol by performing the reaction in an inert solvent.
专利号:US-6716998-B2 优先权日:2001-10-05 标 题:Process for synthesis of 2-yl chroman derivatives 发明人:GROSS JONATHAN L 权利人:WYETH CORP 摘要:This invention provides a process for the stereospecific preparation of 2-yl-chroman and -chromene derivatives of the formula:These compounds are useful for the preparation of optically active 2-aminomethyl- and 2-azaheterocyclylmethyl-chromans.
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合成参考文献
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