CAS: 75-16-1; Methylmagnesium Bromide

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CAS号74-83-9 溴甲烷 | CAS号74-95-3 二溴甲烷 | CAS号110100-09-9 2-(2-氯嘧啶-5-基)丙烷-2-醇 | CAS号10449-86-2 5,10-Dihydro-10... | CAS号107680-06-8 (2R,3R)-2-(2,4-... | CAS号107680-05-7 (3R,2S)-2-(2,4-... | CAS号112182-59-9 2,2-dimethyl-5-... | CAS号1565-75-9 2-苯基-2-丁醇 | CAS号10192-93-5 3,4-二甲基-3,4-二苯基己烷 | CAS号26613-38-7 (2-methyl-1-phe... | CAS号1053655-98-3 1-(异喹啉-8-基)乙酮 | CAS号107971-38-0 PHENYL 3,4-DIHY...

溴甲烷置于碘,Magnesium体系中,用 乙醚 作为反应溶剂,化学反应生成 甲基溴化镁
参考文献:使用手性膦-亚磷酸酯配体的格氏试剂对肉桂酸铜的对映选择性铜催化烯丙基烷基化
标题:使用手性膦-亚磷酸酯配体的格氏试剂对肉桂酸铜的对映选择性铜催化烯丙基烷基化
摘要:使用格氏试剂的铜(i)催化的e-3-芳基-烯丙基氯化物(肉桂酰氯)的s N 2'型烯丙基取代代表了一种合成具有苄基立体中心的化合物的有效方法.通过筛选小的模块化手性膦-亚磷酸酯配体文库,确定了一种新的基于铜(i)的催化剂体系,该体系可以以极高的区域和对映体选择性进行此类反应.使用taddol衍生的配体(3 Mol%),溴化铜(i).二甲基硫醚(cubr.sme 2)(2.5 Mol%)和甲基叔丁基醚(mtbe)获得最佳结果.制备了具有高达99%ee的各种(1-烷基-烯丙基)苯衍生物(gc)的分离产率高达99%.在大多数情况下,产物包含少于3%的线性区域异构体(除了邻位取代的底物).富电子和电子不足的肉桂酰氯均已成功使用.通过比较实验和计算出的cd光谱来确定产品的绝对构型.通过与亚硫酰氯反应,由相应的醇制备底物.通过在mtbe中在三苯基膦(pph 3)(3Mol%)的存在下在低温下用cubr.sme
DOI:10.1002/adsc.201000213

专利信息

专利号:WO-2025053792-A1
优先权日:2023-09-06
标题:Collective synthesis of phantomolin family through total synthesis of the sesquiterpene lactone molephantin
发明人：CHIBA SHUNSUKE; PATOURET REMI HENRI LOUIS; LI HOI YEUNG; LAI SOAK KUAN
权利人:UNIV NANYANG TECH
摘要:Disclosed herein are processes to generate an intermediate in the total synthesis of (+)- molephantin or a derivative thereof, and a total synthesis of (+)-molephantin or a derivative thereof. Also disclosed herein are methods of forming a compound of formula XIV and of forming a compound of formula XV, wherein compound of formula XIV and compound of formula XV are as defined in the description.

专利号:WO-2022256490-A9
优先权日:2021-06-03
标题:Improved synthesis of phosphoramidates for the treatment of hepatitis b virus
发明人：LOCKWOOD MARK
权利人:ANTIOS THERAPEUTICS INC
摘要:The synthesis of phosphoramidate prodrugs useful in the treatment of viral infections is disclosed. Specifically, an improved synthesis of phosphoramidate nucleotides useful in the treatment of Hepatitis B virus is disclosed.

专利号:US-7615169-B2
优先权日:2004-09-20
标题 :Method for synthesis of colloidal nanoparticles
发明人：STROUSE GEOFFREY FIELDING; GERBEC JEFFREY A; MAGANA DONNY
权利人:UNIV CALIFORNIA
摘要:A method for synthesis of high quality colloidal nanoparticles using comprises a high heating rate process. Irradiation of single mode, high power, microwave is a particularly well suited technique to realize high quality semiconductor nanoparticles. The use of microwave radiation effectively automates the synthesis, and more importantly, permits the use of a continuous flow microwave reactor for commercial preparation of the high quality colloidal nanoparticles.

专利号:US-2022267266-A1
优先权日:2019-07-09
标 题 :Improved, cost effective process for synthesis of vitamin d3 and its analogue calcifediol from ergosterol
发明人：DATLA ANUPAMA; NAGRE PRASHANT; TAMORE JAGDISH; PRABHU MANOJKUMAR SADANAND; KADAM SACHIN VASANT
权利人:FERMENTA BIOTECH LTD
摘要:Disclosed herein is an improved and efficient process for synthesis of vitamin D3 and its analogue Calcifediol from Ergosterol. Particularly, the present invention discloses the synthesis of key intermediate 3β-tert-Butyldimethylsilyloxy-22-hydroxy-23,24-bisnorchola-5,7-diene (5), and novel intermediate β-tert-Butyldimethylsilyloxy-22-iodo-23,24-bisnorchola-5,7-diene (9) by a simple and cost effective process. The industrially viable processes for preparation of said intermediate(s) results in providing provitamins with various side chains and the desired products in high yield.

专利号:US-4910310-A
优先权日:1988-10-03
标 题:Synthesis of N-substituted 1,5-dideoxy-1,5-imino-L-fucitol derivatives
发明人：CAMPBELL ARTHUR L; BEHLING JAMES R; BABIAK KEVIN A; NG JOHN S; MUELLER RICHARD A; FLEET GEORGE W J
权利人:SEARLE & CO
摘要:Novel intermediates and method for the chemical synthesis of N-substituted 1,5-dideoxy-1,5-imino-L-fucitol derivatives are provided. A preferred intermediate is 1,5-dideoxy-1,5-imino-3, 4-O-isopropylidene-L-fucitol which is used to prepare the HIV inhibitor 1,5-dideoxy-1,5-imino-[N-ω-methyl caproate]-L-fucitol. These compounds are prepared in a short synthesis from the known compound 2,3-O-isopropylidene-D-lyxono-1,4-lactone or in a multi-step synthesis from D-galactose.

专利号:US-7927516-B2
优先权日:2004-09-20
标题 :Method for synthesis of colloidal nanoparticles
发明人：STROUSE GEOFFREY F; GERBEC JEFFREY A; MAGANA DONNY
权利人:UNIV CALIFORNIA
摘要:A method for synthesis of high quality colloidal nanoparticles using comprises a high heating rate process. Irradiation of single mode, high power, microwave is a particularly well suited technique to realize high quality semiconductor nanoparticles. The use of microwave radiation effectively automates the synthesis, and more importantly, permits the use of a continuous flow microwave reactor for commercial preparation of the high quality colloidal nanoparticles.