CAS: 867160-71-2; Cis-3-(8-Amino-1-(2-Phenylquinolin-7-yl)Imidazo[1,5-A]Pyrazin-3-yl)-1-Methylcyclobutan-1-Ol

上下游产品

CAS号867164-54-3 2-苯基喹啉-7-频哪醇硼酸酯 | CAS号936901-75-6 顺式-3-(8-氨基-1-溴咪... | CAS号936901-73-4 3-(1-BROMO-8-CH...

3-(8-Bromo-1-Chloroh-Pyrrolo[1,2-A]Pyrazin-6-yl)Cyclobutanone无结构图 在 三苯基膦 氨,Caesium Carbonate体系中,用 四氢呋喃,水,N,N-二甲基甲酰胺,异丙醇作为反应溶剂,反应 18.0H,获得 3-[8-Amino-1-(2-Phenylquinolin-7-yl)Imidazo[1,5-A]Pyrazin-3-Yl]-1-Methylcyclobutan-1-Ol
参考文献:[En] Process For The Preparation Of The Compound Osi-906[Fr] Pr°Cédé De Préparation Du Composé Osi-906
标题:[En] Process For The Preparation Of The Compound Osi-906[Fr] Pr°Cédé De Préparation Du Composé Osi-906

专利信息

专利号:US-2024342244-A1
优先权日:2021-07-28
标 题:Isthmin Protein Therapeutics for the Treatment of Non-Alcoholic Fatty Liver Disease
发明人：SVENSSON KATRIN JENNIFER; VOILQUIN LAETITIA
权利人:UNIV LELAND STANFORD JUNIOR
摘要:Compositions and methods are provided for the treatment of one or both of type 2 diabetes and fatty liver disease, e.g. non-alcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH). The adipokine Isthmin-1 (ISM1) protein increases adipose glucose uptake while suppressing hepatic lipid synthesis.

专利号:US-2017107577-A1
优先权日:2014-03-11
标题:Determining Cancer Aggressiveness, Prognosis and Responsiveness to Treatment
发明人：AL-EJEH FARES
权利人:THE COUNCIL OF THE QUEENSLAND INST OF MEDICAL RES
摘要:The invention provides methods of determining the aggressiveness, prognosis and response to therapy for particular cancers, which include comparing the expression levels of one or a plurality of differentially expressed genes from one or more 5 functional metagenes, including a Carbohydrate/Lipid Metabolism metagene, a Cell Signalling metagene, a Cellular Development metagene, a Cellular Growth metagene, a Chromosome Segregation metagene, a DNA Replication/Recombination metagene, an Immune system metagene, a Metabolic Disease metagene, a Nucleic Acid Metabolism metagene, a Post-Translational Modification metagene, a Protein 10 Synthesis/Modification metagene and a Multiple Networks metagene. The method disclosed herein may be particularly suitable as a companion diagnostic for cancer therapies.

专利号:US-2012220595-A1
优先权日:2009-11-12
标题:Deuterated Tyrosine Kinase Inhibitors
发明人：EPSTEIN DAVID M; JIN MEIZHONG; MULVIHILL MARK J
权利人:EPSTEIN DAVID M; JIN MEIZHONG; MULVIHILL MARK J; OSI PHARMACEUTICALS LLC
摘要:Compounds of Formula I, as shown below and defined herein: enriched in deuterium, and pharmaceutically acceptable salts thereof, synthesis, intermediates, formulations, and methods of disease treatment therewith, including cancers mediated at least in part by IGF-1R and/or IR.