CAS: 87-01-4; 7-(Dimethylamino)-4-Methyl-2H-Chromen-2-One

该化合物是一种荧光可塑性诱导物,因其数量产量和光度高,广泛用作激光染色和荧光探针,其结构上有一个二甲基氨电子施放组和一个甲基替代组,这加强了其蓝绿色光谱范围内的斯托克斯转移和排放强度(~460纳米),这种复合物显示出溶血法行为,使其对极度敏感应用很有价值.它还被用于生物化学标签,光电子材料和PH-敏感氟磷.该化合物的合成多功能和与有机和水系统兼容性进一步扩大了其在研究和工业应用中的用途.

英文名称7-(Dimethylamino)-4-Methyl-2H-Chromen-2-One
中文名称7-(二甲基氨基)-4-甲基香豆素
IUPAC名称7-(dimethylamino)-4-methyl-2H-chromen-2-one
其它别名2-Nitrophenol-4-Sulfomethylamide; Cas-87-01-4; Gzeyllpoqrzudf-Uhfffaoysa-N; Fba 52; 7-(Dimethylamino)-4-Methyl-Chromen-2-One; 7-(Dimethylamino)-4-Methylchromen-2-One; Calcofluor Whi
CAS编号87-01-4
MFCD编号:MFCD00006862
EINECS号:201-717-3
FDA UNII编号:TOS1492Q9O
分子式:C12H13NO2
分子量:203.24
产品CID: 2502864
产品分类医药中间体 → 吡喃类化合物

相似结构搜索
产品信息参考;;;;
InChIKey: GZEYLLPOQRZUDF-UHFFFAOYSA-N
InChI=1S/C12H13NO2/c1-8-6-12(14)15-11-7-9(13(2)3)4-5-10(8)11/h4-7H,1-3H3…
计算化学: 氢键受体数3.0氢键供体数0.0可旋转键数1.0

MSDS等安全信息

GHS象形图
GHS符号GHS07 & GHS08;
注释: Exclamation mark & Health hazard
危险类别特定目标器官毒性 - 单次接触类别3
皮肤腐蚀/刺激类别2
严重眼刺激类别2
呼吸道致敏类别1
皮肤致敏类别1
警示词Danger(危险)
危险描述H335 |可能引起呼吸道刺激.
H315 |造成皮肤刺激.
H319 |造成严重眼刺激.
H334 |吸入可能引起过敏或哮喘症状或呼吸困难.
H317 |可能引起皮肤过敏反应.
防范说明P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313
危险品标志Xi
安全声明22-36/37/39-36-26
危险类别码20/21/22-36/37/38

欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

CAS号141-97-9 乙酰乙酸乙酯 | CAS号99-07-0 N,N-二甲基间羟基苯胺 | CAS号99-07-0 N,N-二甲基间羟基苯胺

合成工艺路线路线简述

141-97-9 + 99-07-0 = 87-01-4
反应条件:1.1 Catalysts: Methanesulfonic Acid,1,1,1-Trifluoro-,Erbium(3+) Salt (3:1) Solvents: Toluene; 8 H,110 °C
标题:Er(Otf)3-Catalyzed Synthesis Of Fluorescent 7-Aminocoumarins
作者:Bao,Xiaobo; Et Al
参考文献:Tetrahedron 日期:2022 卷标:123]

26093-31-2 = 87-01-4
反应条件:1.1 Reagents: Potassium Carbonate Solvents: Dimethylformamide; 6 H,Rt -> 60 °C; 60 °C -> Rt1.2 Solvents: Water-D2; Rt
标题:A General Strategy To Enhance Donor-Acceptor Molecules Using Solvent-Excluding Substituents
作者:Hoelzel,Conner A.; Et Al
参考文献:Angewandte Chemie 日期:2020 卷标:59(12) 页码:4785-4792]

16919-18-9 = 87-01-4 + 16919-18-9
反应条件:1.1 Solvents: Acetonitrile
标题:Preparation,Photochemistry,And Electronic Structures Of Coumarin Laser Dye Complexes Of Cyclopentadienylruthenium(Ii)
作者:Koefod,Robert S.; Et Al
参考文献:Inorganic Chemistry 日期:1989 卷标:28(12) 页码:2285-90]

141-97-9 + 99-07-0 = 87-01-4
反应条件:1.1 Catalysts: 2924486-53-1,2924486-54-2; 5 H,Rt -> 90 °C
标题:Development And Application Of A Supramolecular Bronsted Acid Catalyst Based On The Noria Macrocycle
作者:Hasselbrink,Carson Lawrence; Et Al
参考文献:Journal Of Organic Chemistry 日期:2022 卷标:87(23) 页码:16074-16078]

141-97-9 + 99-07-0 = 87-01-4
反应条件:1.1 Reagents: Zinc Chloride Solvents: Ethanol; 20 H,Rt -> Reflux; Reflux -> Rt1.2 Reagents: Hydrochloric Acid Solvents: Water; 2 H,Rt
标题:Enantioselective Synthesis And Application Of Small And Environmentally Sensitive Fluorescent Amino Acids For Probing Biological Interactions
作者:Noden,Michael; Et Al
参考文献:Journal Of Organic Chemistry 日期:2021 卷标:86(17) 页码:11407-11418]

506-59-2 + 878672-65-2 = 87-01-4
反应条件:1.1 Reagents: Cesium Carbonate Catalysts: Tris(Dibenzylideneacetone)Dipalladium,X-Phos Solvents: 1,4-Dioxane; 4 H,100 °C
标题:Azetidine-Containing Heterospirocycles Enhance The Performance Of Fluorophores
作者:Zhou,Junliang; Et Al
参考文献:Organic Letters 日期:2020 卷标:22(11) 页码:4413-4417]

68076-36-8 + 80883-54-1 = 87-01-4
反应条件:1.1 Reagents: Diisopropylethylamine,O-(7-Azabenzotriazol-1-Yl)-N,N,N′,N′-Tetramethyluronium Hexafluorophosphate Solvents: Dimethylformamide; 1 H,Rt1.2 Solvents: Dimethylformamide; 4 H,Rt
标题:Bromophycolide A Targets Heme Crystallization In The Human Malaria Parasite Plasmodium Falciparum
作者:Stout,E. Paige; Et Al
参考文献:Chemmedchem 日期:2011 卷标:6(9) 页码:1572-1577]

99-07-0 + 1830-54-2 = 87-01-4
反应条件:1.1 Reagents: Sulfuric Acid Solvents: Methanol; Overnight,Rt
标题:Evaluation Of Novel Fluorescence Probes For Conjugation Purposes Using The Traceless Staudinger Ligation
作者:Wodtke,Robert; Et Al
参考文献:Dyes And Pigments 日期:2015 卷标:113 页码:263-273

Alkaline Earth Salt Of/the/ Methylsulfuric Acid 反应生成 7-二甲氨基-4-甲基香豆素
参考文献:Dey,Journal Of The Chemical Society,1915,Vol. 107,P. 1637
标题:Dey,Journal Of The Chemical Society,1915,Vol. 107,P. 1637

专利信息

专利号:US-12006540-B2
优先权日:2015-09-28
标题:Synthesis of novel disulfide linker based nucleotides as reversible terminators for DNA sequencing by synthesis
发明人：JU JINGYUE; LI XIAOXU; CHEN XIN; LI ZENGMIN; KUMAR SHIV; SHI SHUNDI; GUO CHENG; REN JIANYI; HSIEH MIN-KANG; CHIEN MINCHEN; TAO CHUANJUAN; ERTURK ECE; KALACHIKOV SERGEY; RUSSO JAMES J
权利人:UNIV COLUMBIA
摘要:Disclosed herein, inter alia, are compounds, compositions, and methods of use thereof in the sequencing of a nucleic acid.

专利号:US-5419966-A
优先权日:1991-06-10
标题 :Solid support for synthesis of 3'-tailed oligonucleotides
发明人：REED MICHAEL W; MEYER JR RICH B; PETRIE CHARLES R; TABONE JOHN C
权利人:MICROPROBE CORP
摘要:A solid support for oligonucleotide synthesis has the structure where CPG represents a controlled pore glass matrix, the wavy line represents a carbon chain covalently linking the NH group with the controlled pore glass matrix, X is 2,2'-dimethoxytrityl or H, and R is alkyl, aryl, arylalkyl, heteroalkyl, or heteroaryl. The dimethoxytrityl group is removed from the solid support by treatment with acid, and the oligonucleotide is built, step-by-step in a conventional synthesizer after attachment of the 3' end of the first oligonucleotide unit to the hydroxyl function connected to the R group.

专利号:US-11959137-B2
优先权日:2015-09-28
标题:Synthesis of novel disulfide linker based nucleotides as reversible terminators for DNA sequencing by synthesis

专利号:US-2024376536-A1
优先权日:2015-09-28
标题 :Design and synthesis of novel disulfide linker based nucleotides as reversible terminators for dna sequencing by synthesis

专利号:US-2022411860-A1
优先权日:2015-09-28
标题:Design and synthesis of novel disulfide linker based nucleotides as reversible terminators for dna sequencing by synthesis

专利号:US-2023160000-A1
优先权日:2015-09-28
标题:Synthesis of novel disulfide linker based nucleotides as reversible terminators for dna sequencing by synthesis