CAS: 99586-65-9; 4-Chloropicolinamide

相似化合物

19235-89-3 180748-30-5 220000-87-3

上下游产品

4-Chloro-pyridine-2-carboxylic acid methyl ester ammonia 4-chloro-pyridine-2-carbonitrile 4-chloro-pyridine-2-carbonyl chloride 2-Amino-4-chloropyridine 4-(4-amino-3-fluorophenoxy)pyridine-2-carboxyamide 4-(3-Fluoro-4-{[1-(4-fluorophenylcarbamoyl)cyclopropanecarbonyl] amino }phenoxy)pyridine-2-carboxamide 4-(4-amino-2,5-difluorophenoxy)picolinamide

2-吡啶甲酸置于ammonium Hydroxide,氯化亚砜,Sodium Bromide体系中,用 氯苯,甲苯 作为反应溶剂,化学反应 25.0H,反应生成 4-氯吡啶-2-甲酰胺
参考文献:带有缩氨基脲部分的新型 4-(2-氟苯氧基)-2-(1H-四唑-1-基)吡啶作为有效抗肿瘤剂的合成和生物学评价
标题:带有缩氨基脲部分的新型 4-(2-氟苯氧基)-2-(1H-四唑-1-基)吡啶作为有效抗肿瘤剂的合成和生物学评价
摘要:合成了一系列带有缩氨基脲部分的 4-(2-氟苯氧基)-2-(1H-四唑-1-基)吡啶,并评估了它们的体外抗肿瘤效力.与索拉非尼和 Pac-1 相比,一些化合物(10B,10C,10E-10H,10M-10P,10R 和 11B)表现出中等至优异的抗肿瘤活性,以及对人胎肺成纤维细胞的低毒性细胞系 Wi-38.最有希望的化合物 10P(ic50 = 0.08,0.36,0.97 µm)的活性是索拉非尼的 45.1-,6.1-和 2.4 倍(ic50 = 3.61,2.19,2.32 µm),是 17,2.9 倍和 17 倍,更好pac-1 (Ic50 = 1.36,1.17,2.83 µm) 分别对抗三种癌细胞系(ht-29,H460 和 Mkn-45).此外,
DOI:10.1002/ardp.201300188

专利信息

专利号:US-8372971-B2
优先权日:2004-08-25
标 题:Heterocyclic compounds and methods of use
发明人：WRASIDLO WOLFGANG; DNEPROVSKAIA ELENA
权利人:TARGEGEN INC; WRASIDLO WOLFGANG; DNEPROVSKAIA ELENA
摘要:Heterocyclic compounds derived from benzotriazine, triazines, triazoles and oxadiazoles are disclosed. The methods of synthesis and of use of such heterocyclic compounds are also provided.

专利号:US-9181188-B2
优先权日:2002-02-11
标 题:Aryl ureas as kinase inhibitors
发明人：DUMAS JACQUES; SCOTT WILLIAM J; CHIEN DU-SCHIENG; NASSAR ALA; LEE WENDY; BJORGE SUSAN; MUSZA LASZLO L; RIEDL BERND
权利人:DUMAS JACQUES; SCOTT WILLIAM J; CHIEN DU-SCHIENG; NASSAR ALA; LEE WENDY; BJORGE SUSAN; MUSZA LASZLO L; RIEDL BERND; BAYER HEALTHCARE LLC
摘要:This invention relates to new aryl ureas and methods for their synthesis. The inventive compounds are useful in the treatment of (i) raf mediated diseases, for example, cancer, (ii) p38 mediated diseases such as inflammation and osteoporosis, and (iii) VEGF mediated diseases such as angiogenesis disorders.

专利号:CN-112679424-A
优先权日:2019-10-18
标 题:Synthesis method of regorafenib

专利号:CN-112851677-A
优先权日:2019-11-26
标题:Synthesis method of imidazopyridine or pyrimidine derivative