CAS: 1073-13-8; 4,4-Dimethyl-2-Cyclohexen-1-One

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5020-09-7 35161-12-7 17429-32-2

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CAS号932-01-4 4,4-二甲基环己-1-醇 | CAS号78-94-4 丁烯酮 | CAS号78-84-2 异丁醛 | CAS号13544-11-1 2,2-dimethyl-5-... | CAS号930-68-7 环己烯酮 | CAS号80663-78-1 3-chloro-6,6-di... | CAS号2403-57-8 1-(2-甲基-1-丙烯基)吡咯烷 | CAS号7664-93-9 硫酸 | CAS号4255-62-3 4,4-二甲基环己酮 | CAS号5020-09-7 4,4-dimethylcyc... | CAS号932-01-4 4,4-二甲基环己-1-醇 | CAS号1846-48-6 6,6-dimethylbic... | CAS号37165-47-2 (4aR,4bR,8aS,8b... | CAS号37402-51-0 (4aS,4bS,8aS,8b... | CAS号65638-73-5 2-benzyl-4,4-di... | CAS号1619-28-9 3-isopropyl-2-c... | CAS号32264-57-6 4,4,6,6-tetrame...

4,4-二甲基环己酮置于1,10-菲罗啉,三氟甲磺酸三甲基硅酯,Bis(Acetoxy)Iodylbenzene体系中,用 氘代乙腈 用作溶剂,化学反应 0.5H,以70%的收率获得4,4-二甲基-2-环己基-1-酮
参考文献:双齿氮连接 I(V) 试剂,Bi(N)-Hvi:制备,稳定性,结构和反应性
标题:双齿氮连接 I(V) 试剂,Bi(N)-Hvi:制备,稳定性,结构和反应性
摘要:高价碘 (V) 试剂是一类强效有机氧化剂.虽然 I(V) 化合物戴斯-马丁高碘烷和 Ibx 的使用很广泛,但此类试剂长期以来一直受到溶解度和稳定性问题的困扰.人们为衍生这些支架以调节反应性和物理性质做出了广泛的努力,但仍然存在相当大的创新空间.在此,我们描述了一种新兴的 I(V) 试剂 Bi(N)-Hvi 的制备,热稳定性,优化的几何结构和合成实用性,Bi( N )-Hvi 在碘中心上具有配位结合的二齿氮配体. Bi( N )-Hvi 表现出非常好的安全性,更高的溶解度,并且相对于常见的 I(V) 试剂具有优异的氧化反应性. Bi( N )-Hvi的高度模块化合成和原位生成为i(V)试剂和反应开发提供了新颖且便捷的筛选平台.
Doi:10.1021/acs.Joc.1C00375

专利信息

专利号:US-5780603-A
优先权日:1996-11-15
标题:Combinatorial synthesis of carbohydrate libraries
发明人：HINDSGAUL OLE
权利人:SYNSORB BIOTECH INC
摘要:Disclosed are methods for synthesizing very large collections of diverse thiosaccaride derivatives optionally attached to a solid support. Also disclosed are libraries of diverse thiosaccaride derviatives.

专利号:US-5965719-A
优先权日:1996-11-15
标 题:Combinatorial synthesis of carbohydrate libraries
发明人：HINDSGAUL OLE
权利人:SUNSORB BIOTECH INC
摘要:Disclosed are methods for synthesizing very large collections of diverse thiosaccharide derivatives optionally attached to a solid support. Also disclosed are libraries of diverse thiosaccharide derivatives.

专利号:US-9090545-B2
优先权日:2011-10-14
标 题 :Asymmetric synthesis of organic compounds
发明人：FLETCHER STEPHEN P; MAKSYMOWICZ REBECCA M; ROTH PHILIPPE M C
权利人:ISIS INNOVATION
摘要:The present invention provides processes for the production of chiral compounds in a stereoisomeric excess. The present processes involve reacting a hydrometallated alkene compound with a compound comprising a conjugated-bond system under conditions such that the compounds undergo an asymmetric 1,4- or 1,6-conjugate addition reaction, generating a chiral compound in a stereoisomeric excess. The reaction is performed in the presence of a metal catalyst, which catalyst preferably comprises a non-racemic chiral ligand.

专利号:US-7902196-B2
优先权日:2005-03-17
标 题 :Synthesis of avrainvillamide, strephacidin B, and analogues thereof
发明人：MYERS ANDREW G; HERZON SETH B; WULFF JEREMY EARLE; SIEGRIST ROMAIN; SVENDA JAKUB; ZAJAC MATTHEW ALLEN
权利人:HARVARD COLLEGE
摘要:The syntheses of the natural products, avrainvillamide and stephacidin B, are provided. The α,β-unsaturated nitrone functionality of avrainvillamide and its 3-alkylidene-3H-indole 1-oxide core is shown to covalently and reversibly bond to heteroatom-based nucleophiles. This capability may allow these molecules to bind active site nucleophiles and may provide the basis for designing potent and selective enzyme inhibitors. Both avrainvillamide and its dimer stephacidin B have been reported to exhibit antiproliferative activity, and avrainvillamide has been reported to exhibit antimicrobial activity against multi-drug resistant bacteria. Avrainvillamide has been found to target cytoskeleton-linking membrane protein (CLIMP-63) thereby preventing cells from undergoing mitosis. The invention provides syntheses of these natural products as well as analogs of these natural products and their functional cores. The compounds of the invention may be used in the treatment of diseases such as cancer, autoimmune diseases, and bacterial infection.

专利号:US-2009143581-A1
优先权日:2005-03-17
标题 :Synthesis of avrainvillamide, strephacidin b, and analogues thereof

专利号:CA-2601135-A1
优先权日:2005-03-17
标 题 :Synthesis of avrainvillamide, stephacidin b, and analogues thereof