CAS: 16883-45-7; Tetramethylammonium Tetrahydroborate

该化合物是一种该化合物是一种稳定,可溶的减少剂,在有机和无机合成方面特别有用.甲基二甲胺具有一些优势,如在温和条件下具有高反应性,在减少碳基化合物方面有选择性,与水和酒精等极溶剂的兼容性.其离子特性会提高各种反应介质的溶性,促进同质反应.此外,与碱性金属卤氢化合物相比,甲基二乙酰二酰二甲苯二甲醚的湿性较低,可改善处理和储存稳定性.这些特性使得它成为受控制地减少制药,材料和精细化学应用的宝贵试剂.

结构式图片

相似化合物

75-58-1 75-57-0 64-20-0

欧盟法规

ECHA物质ECHA物质C&L通报REACH预注册

上下游产品

CAS号75-59-2 四甲基氢氧化铵 | CAS号16940-66-2 硼氢化钠 | CAS号75-57-0 四甲基氯化铵 | CAS号64-20-0 四甲基溴化铵 | CAS号75-22-9 三甲胺-硼烷络合物 | CAS号109704-53-2 四甲基三乙酰氧硼氢化铵

合成工艺路线路线简述

    硼氢化钠,四甲基氢氧化铵,水 以81%的收率获得
    参考文献:Evans,D. A.;Chapman,K. T.;Carreira,E. M.,J. Amer. Chem. Soc.,110,(1988) N 11,C. 3560-3578
    标题:Evans,D. A.;Chapman,K. T.;Carreira,E. M.,J. Amer. Chem. Soc.,110,(1988) N 11,C. 3560-3578

    海关参考信息

    专利信息


    专利号:US-2024239791-A1
    优先权日:2021-04-26
    标题 :Processes for the synthesis of valbenazine
    发明人:TUCKER JOHN LLOYD
    权利人:NEUROCRINE BIOSCIENCES INC
    摘要:The present application relates to processes for preparing (S)-(2R,3R,11bR)-3-isobutyl-9,10-dimethoxy-2,3,4,6,7,11b-hexahydro-1H-pyrido[2,1-a]isoquinolin-2-yl 2-amino-3-methylbutanoate di(4-methylbenzenesulfonate), which is an inhibitor of vesicular monoamine transporter 2 (VMAT2) useful in the treatment of hyperkinetic movement disorders such as tardive dyskinesia (TD).

    专利号:US-2022363680-A1
    优先权日:2019-09-13
    标题 :Processes for the synthesis of valbenazine
    发明人:TUCKER JOHN; KUCERA DAVID; HETTINGER DONALD; COCHRAN BRIAN M; BRANUM SHAWN; LE JACKIE; MCGEE KEVIN
    权利人:NEUROCRINE BIOSCIENCES INC
    摘要:The present application relates to processes for making (2R,3R,11bR)-3-isobutyl-9,10-dimethoxy-2,3,4,6,7,11b -hexahydro-1H-pyrido[2,1-a]isoquinolin-2-yl (S)-2-amino-3-methylbutanoate di(4-methylbenzenesulfonate), which is an inhibitor of vesicular monoamine transporter 2 (VMAT2) useful in the treatment of hyperkinetic movement disorders such as tardive dyskinesia (TD).

    专利号:US-7576240-B2
    优先权日:2006-04-26
    标 题 :Arylamine processes
    发明人:MURPHY LEANNE DAWN
    权利人:XEROX CORP
    摘要:Processes for selectively hydrogenating double and/or triple bonds in organic molecules include providing at least one organic molecule containing a double and/or triple bond, providing at least one hydrogen donor molecule, and hydrogenating the double and/or triple bond in the presence of at least one catalyst. Processes for preparing arylamine molecules include selectively hydrogenating double bonds in arylamine compounds by providing at least one organic molecule containing a multiple bond, providing at least one hydrogen donor molecule, and hydrogenating the multiple bond in the presence of at least one catalyst. The processes provide efficient, cost-effective and safe methods for conducting selective hydrogenation reactions in the synthesis of organic molecules, such as charge-transport molecules.

    专利号:US-2008076049-A1
    优先权日:2006-09-26
    标 题 :Arylamine processes
    发明人:SABAN MARKO D; MURPHY LEANNE DAWN; ENRIGHT THOMAS EDWARD
    权利人:XEROX CORP
    摘要:Continuous and batch processes for selectively hydrogenating double and/or triple bonds in organic molecules include providing at least one organic molecule containing a double and/or triple bond, providing at least one hydrogen donor molecule, and hydrogenating the double and/or triple bond in the presence of at least one catalyst. Continuous and batch processes for preparing arylamine molecules include selectively hydrogenating double bonds in arylamine compounds by providing at least one organic molecule containing a multiple bond, providing at least one hydrogen donor molecule, and hydrogenating the multiple bond in the presence of at least one catalyst. The continuous and batch processes provide efficient, cost-effective and safe methods for conducting selective hydrogenation reactions in the synthesis of organic molecules, such as charge-transport molecules.

    专利号:WO-2022232060-A1
    优先权日:2021-04-26
    标 题:Processes for the synthesis of valbenazine

    专利号:WO-2009143405-A2
    优先权日:2008-05-22
    标 题:Synthesis of graphene sheets and nanoparticle composites comprising same
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    主要参考文献

    参考标题:Carbapenams And Carbapen-2-Ems And Process Therefor
    摘要:Carbapenam-3-Carboxylic Acids And Carbapen-2-Em-3-Carboxylic Acids Substituted At The 1-Position With An Oxo, A Hydroxy Or An Acetoxy Group, Variously Substituted At The 2-Position With Such Groups As Methyl, Acetoxymethyl, Methanesulfonyloxy, Alkoxy, Alkylthio, Aminoalkylthio Or Amidinoalkylthio And Optionally Substituted At The 6-Position With A Hydroxyalkyl Group, An Acetoxyalkyl Group Or A Conventional Penicillin Side-Chain, Pharmaceutically-Acceptable Salts Thereof And Various Esters Thereof Wherein The Esterifying Group Is Selectively Removed In The Laboratory, Or Hydrolyzed Under Physiological Conditions. These Compounds Are Useful Either Systemically Or Topically In The Treatment Of Diseases Caused By Susceptible Microorganisms, As Animal Feed Additives For Promotion Of Growth, Or In The Preservation Of Biodegradable Materials, Or As Intermediates To Compounds Having Such Antibacterial Activity. Key To The Synthesis Of These Compounds Is The Light Catalyzed Rearrangement Of 2-Diazo-1-Oxoceph-3-Em-4-Carboxylates To 1-Oxocarbapen-2-Em-3-Carboxylates, A Newly Discovered Reaction Determined To Be Of General Applicability.

    合成参考文献


    摘要:National Technical Information Service., ORNL-5576
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