CAS: 17420-30-3; 2-Amino-5-Nitrobenzonitrile

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2-氯-5-硝基苯甲腈置于ammonium Hydroxide,Copper(L) Iodide体系中,化学反应 6.5H,反应生成2-氰基-4-硝基苯胺
参考文献:绿色和可回收的无配体无铜(i)催化体系,用于氨水溶液中的卤代硝基苯胺的胺化
标题:绿色和可回收的无配体无铜(i)催化体系,用于氨水溶液中的卤代硝基苯胺的胺化
摘要:卤代硝基苯的胺化是生产相应硝基苯胺的重要反应.的直接胺化p-Chloronitrobenzene(p-Cnb)至p硝基苯胺(p-Nan)用含水nh 3溶液在不存在配体,无机碱和有机溶剂的研究了在各种过渡金属的盐.已经发现,就p-Cnb转化,P-Nan选择性(~100%)以及反应后分离和再循环而言,Cui是最有效的催化剂.高p的97%-Nan收率在200oc下在6.5小时,用nh的摩尔比来获得3 / P-Cnb和cui /p-Cnb分别为21和0.1.提出了一种可能的反应机理,其中nh 3不仅是底物,而且还是与cui配位的配体,形成了水溶性cu配合物,然后开始催化循环.研究了诸如nh 3浓度,Cui浓度,温度和时间等反应变量对p-Cnb转化率和p-Nan选择性的影响.在室温下,所需的p-Nan产物不溶于水,但cu络合物催化剂是水溶性的,因此包含催化剂和nh 3的水相可以轻松
Doi:10.1016/j.Mcat.2019.110462

专利信息

专利号:WO-2014170910-A1
优先权日:2013-04-04
标 题:Process for the preparation of lapatinib
发明人：MUDDASANI PULLA REDDY; TALASILA SAMBASIVA RAO; SATTI VENKATA REDDY; NEKKANTI SATISH CHOWDARY; NANNAPANENI VENKAIAH CHOWDARY
权利人:NATCO PHARMA LTD
摘要:Present process relates to an improved and commercial process for the preparation of lapatinib of formula-I or its pharmaceutically acceptable p-toluenesulfonate salt involving novel intermediates of formulae-XVII, XVIII, and XIX. Present process utilizes Meerwein reaction as a key step in the aryl C-C bond formation step avoiding costly boronate coupling chemistry used in the conventional synthesis of lapatinib.

专利号:US-4719053-A
优先权日:1980-08-01
标题 :Beta-chloroethylsulfonylmethyl-benzoic halides as intermediates
发明人：SCHLAEFER LUDWIG; HAEHNLE REINHARD
权利人:HOECHST AG
摘要:New beta -chloroethylsuflonylmethyl-benzoic acid halides which can serve as fibre-reactive anchors for thesynthesis of novel organic, water-soluble compounds, preferably dyestuffs, having fibre-reactive and fibre-finishing properties, such as preferably dyestuff properties, and containing, as a fibre-reactive group, one or two beta -chloroethylsufonylmethylbenzoic acid amide groups. For the synthesis of these novel fibre-finishing compounds, said new beta -chloroethylsulfonylmethyl-benzoic acid halide compounds are reacted with an organic, water-soluble compound having fibre-finishing properties and continuing one or two amino groups. Also precursors of the fibre-finishing, fibre-reactive compounds, containing said beta -chloroethylsulfonylmethyl-benzxoic acid amid grouping, can be employed for their synthesis. The novel fibre-finishing compounds can be applied onto suitable fibre materials, such as especially cellulose fibre material and natural or synthetic polyamide fibre materials, and fixed on these fibre materials in a manner similar to application and fixation methods usual in the technique for fibre-reactive compounds. The fibre-finished material, such as dyed material, shows very good wet fastnesses.

专利号:US-4257942-A
优先权日:1977-10-06
标题:New water-insoluble azo dyes
发明人：DEFEO FRANCESCO; CIPOLLI ROBERTO
权利人:ACNA
摘要:The present invention relates to the synthesis of new dyes having the following general formula: wherein: D is the residue of a diazotizable component of the carbocyclic or heterocyclic series X is an ethylene group, optionally substituted by halogen-methyl, alkyl C1-C4, aryl, aralkyl or CH2OCO(HN)nR (wherein R and n have the meanings hereinafter defined); R is alkyl C1-C8 optionally substituted by halogen, CN,COOH; aryl optionally substituted by one or more atoms of halogen, alkyl C1-C4, alkoxyl C1-C4; alkoxyl C1-C4; alkoxyl C1-C8; Aryloxy; aralkoxy; cycloalkoxy; aralkyl; naphthyl optionally substituted by halogen; alkenyl C2-C8, optionally substituted by halogen, CN, COOH; R1 and R2, either like or unlike each other, may be alkyl C1-C4 optionally substituted by halogen or CN groups; aralkyl; R3 is H; halogen, alkyl C1-C4; alkoxyl C1-C4, optionally substituted. n is 0 or 1.

专利号:US-4740604-A
优先权日:1986-05-26
标题:Benzanthrone lactones
发明人：WEIS CLAUS D; SUTTER PETER
权利人:CIBA GEIGY CORP
摘要:There are disclosed benzanthrone lactones of formula ##STR1## wherein R 1 , R 2 and R 3 are as defined in claim 1. The benzanthrone lactones of formula (1) are important intermediates for the synthesis of novel dyes which are obtained by coupling suitable diazo components to said compounds of formula (1).

专利号:US-4118384-A
优先权日:1976-02-21
标题 :Process for preparation of azo dyestuffs by coupling in presence of aromatic sulphonic acid-formaldehyde reaction product
发明人：MOLLS HANS-HEINZ; SCHIWY WILLY; HORNLE REINHOLD; NEBELING REINHARD
权利人:BAYER AG
摘要:Dyestuff dispersions and dyestuff solutions free from salt or at least having a low salt content are obtained in that the diazotization is carried out with addition of free dispersing agent acid to which, after the synthesis, either no basic agents are added or basic agents are added only up to a pH value of 3. The disclosed process gives dyestuff compositions of low salt content and results in readily dispersible dyestuffs when water insoluble dyestuffs are prepared and stable solutions when water soluble dyestuffs are prepared. The process is widely applicable and chemical constitution of the dyestuffs is conventional.

专利号:US-7572798-B2
优先权日:2001-02-26
标题 :Combi-molecules having signal transduction inhibitory properties and DNA damaging properties
发明人：JEAN-CLAUDE BERTRAND J; DUDOUIT FABIENNE; MATHESON STEPHANIE
权利人:UNIV MCGILL
摘要:The present invention relates to a series of new chemical agents that demonstrate anti-tumor activity. More particularly, the present invention relates to molecules, referred to as “combi-moleculesâ€?, that combine two major mechanisms of anti-tumor action. A combi-molecule is capable of degrading to a ligand involved in cell signaling pathways and to an agent capable of damaging DNA. More specifically, the present invention relates to molecules capable of blocking epidermal growth factor receptor (EGFR) mediated signal transduction and capable of damaging DNA. The present invention also relates to a general method of synthesis of these combi-molecules.