CAS: 253342-48-2; 4,4,5,5-Tetramethyl-2-(M-Tolyl)-1,3,2-Dioxaborolane

上下游产品

toluene 4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane bis(pinacol)diborane 2-(3-chloro-5-methylphenyl)-4,4,5,5-tetra methyl-1,3,2-dioxaborolane 2-(3-(bromomethyl)phenyl)-4,4,5,5,-tetramethyl-1,3,2-dioxaborolane m-tolylboronic acid p-tolylboronic pinacol ester 2-methylphenylboronic acid pinacol ester

1-甲基-3-(甲硫基)苯置于吡啶体系中,用 水,1,2-二氯乙烷,丙酮 用作溶剂,化学反应 24.0H,反应生成3-甲基苯硼酸频呐醇酯
参考文献:通过光激活的cs活化,芳基s盐的氧化还原中性硼化反应.
标题:通过光激活的cs活化,芳基s盐的氧化还原中性硼化反应.
摘要:本文报道了一种使用双(频哪醇)二硼作为硼源进行芳基sulf盐的硼化的新光诱导策略.该方法利用氧化还原中性芳基sulf在无过渡金属条件下进行光激发时通过cs键活化来获得芳基自由基.因此,它可从容易获得的芳基sulf获得具有非常好性能的各种芳基硼酸酯,并伴有温和的条件,操作简便和易于扩展.
Doi:10.1021/acs.Orglett.9B03850

专利信息

专利号:WO-2012173572-A1
优先权日:2011-06-10
标 题 :Stereoselective synthesis of highly substituted enamides
发明人：PARK CHEOL-MIN; LIU YU
权利人:UNIV NANYANG TECH; PARK CHEOL-MIN; LIU YU
摘要:The disclosure provides new methods for the oxidative Heck cross-coupling reaction with electron-rich alkenes such as substituted β-amidoacrylate and other related substituted enamides. Previously, functionalization of enamides under Heck conditions has been limited to those with unsubstituted vinyl groups. By tuning the reaction parameters that allow for the balance between stability and reactivity of the reactants, the oxidative Heck cross-coupling reaction now provides highly substituted enamides in good to excellent yields. (II) (III) (I)·

专利号:US-9243004-B2
优先权日:2011-07-22
标题 :Synthesis of boronic esters and boronic acids using grignard reagents
发明人：CLARY JACOB W; SINGARAM BAKTHAN
权利人:CLARY JACOB W; SINGARAM BAKTHAN; UNIV CALIFORNIA
摘要:Boronic esters and boronic acids are synthesized at ambient temperature in an ethereal solvent by the reaction of Grignard reagents with a boron-containing substrate. The boron-containing substrate may be a boronic ester such as pinacolborane, neopentylglycolborane, or a dialkylaminoborane compound such as diisopropylaminoborane. The Grignard reagents may be pre-formed or generated from an alkyl, alkenyl, aryl, arylalkyl, heteroaryl, vinyl, or allyl halide compound and Mg 0 . When the boron-containing substrate is a boronic ester, the reactions generally proceed at room temperature without added base in about 1 to 3 hours to form a boronic ester compound. When the boron-containing substrate is a dialkylaminoborane compound, the reactions generally proceed to completion at 0° C. in about 1 hour to form a boronic acid compound.

专利号:US-11066395-B2
优先权日:2016-09-30
标题:Dimethylaminoethanol salt of a GLP-1 receptor modulator
发明人：VIDAL EPHRAIM; BAKALE ROGER; TURNBULL PHILIP; MOSER DAVID; ROBBINS ANDREW; GRANT CRAIG
权利人:RECEPTOS LLC
摘要:Crystalline 2-hydroxy-N,N-dimethylethanaminium 1-(2-(5-(tert-butyl)-thiophene-2-carboxamido)-3-(4-(5-(4′-ethyl-[1,1′-bi(cyclohexan)]-3-en-4-yl)pyrimidin-2-yl)phenyl)propanoyl)azetidine-3-carboxylate salt, and methods related to synthesis and therapeutic use of the same.

专利号:JP-2012528861-A
优先权日:2009-06-03
标 题 :Stereoselective synthesis of specific trifluoromethyl substituted alcohols.