专利号:US-8420848-B2 优先权日:2009-01-09 标题:Process for the synthesis of beta glycerol phosphate 发明人:KULKARNI YASHWANT 权利人:KULKARNI YASHWANT; SIGMA ALDRICH CO LLC 摘要:The present invention provides methods for the preparation of beta glycerol phosphate and its salts. In particular, the invention provides efficient methods for the synthesis of beta glycerol phosphate of high purity.
专利号:WO-2009028973-A1 优先权日:2007-08-31 标 题:Massive production of mycobacterial glucosyl-3-phosphoglycerate synthase and the use of this enzyme as a target for antimycobacterial substances 发明人:SIMOES DA COSTA MILTON; DA SILVA EMPADINHAS NUNO MIGUEL 权利人:BIOCANT PARK CT DE INOVACAO EM; SIMOES DA COSTA MILTON; DA SILVA EMPADINHAS NUNO MIGUE 摘要:The present invention describes the isolation, identification and characterization of a gene (gpgS) and of the function of the corresponding enzyme responsible for the synthesis of glucosyl-3-phosphoglycerate (GpgS), the precursor of glucosylglycerate, a component of the methylglucose polysaccharides from mycobacteria and some closely related bacteria. This gene is conserved among mycobacteria and is essential for the growth of Mycobacterium tuberculosis, the causative agent of tuberculosis. The invention discloses the gpgS gene, processes for production of the enzymes encoded by the genes from Mycobacterium bovis and Mycobacterium smegmatis, the properties of the enzymes, the construction of plasmids that include the genes and of Escherichia coli clones containing these plasmids and that can be used for the large scale production of the enzymes, aiming at the identification or development of specific molecules that can inhibit this enzyme involved in the metabolic pathway leading to the synthesis of the methylglucose polysaccharides from mycobacteria. Therefore the present invention is applicable to the area of the pharmaceutical industry.
专利号:US-8202985-B2 优先权日:2005-10-31 标 题:Monomer compositions for the synthesis of polynucleotides, methods of synthesis, and methods of deprotection 发明人:DELLINGER DOUGLAS J; TIMAR ZOLTAN; SIERZCHALA AGNIESZKA; DELLINGER GERALDINO; CARUTHERS MARVIN H 权利人:DELLINGER DOUGLAS J; TIMAR ZOLTAN; SIERZCHALA AGNIESZKA; DELLINGER GERALDINO; CARUTHERS MARVIN H; AGILENT TECHNOLOGIES INC; UNIV COLORADO 摘要:Nucleotide monomers, polynucleotides, methods of making each, and methods of deprotecting each, are disclosed. An embodiment of the nucleotide monomer, among others, includes a nucleotide monomer having a heterobase protecting group selected from structures I through III as described herein. An embodiment of the polynucleotide, among others, includes a plurality of nucleotide moieties having a heterobase protecting group selected from one of structures I through III as described herein.
专利号:US-7759471-B2 优先权日:2005-10-31 标题 :Monomer compositions for the synthesis of RNA, methods of synthesis, and methods of deprotection 发明人:DELLINGER DOUGLAS J; TIMAR ZOLTAN; SIERZCHALA AGNIESZKA; DELLINGER GERALDINE; CARUTHERS MARVIN H 权利人:AGILENT TECHNOLOGIES INC; UNIV COLORADO 摘要:Nucleotide monomers, polynucleotides, methods of making each, methods of deprotecting each, and the like are disclosed herein.
专利号:US-9935319-B2 优先权日:2011-06-17 标题 :Synthesis of hetero ionic compounds using dialkylcarbonate quaternization 发明人:FRIESEN CODY A; WOLFE DEREK; JOHNSON PAUL BRYAN 权利人:FLUIDIC INC 摘要:Methods of preparing hetero ionic complexes, and ionic liquids from bisulfate salts of heteroatomic compounds using dialkylcarbonates as a primary quaternizing reactant are disclosed. Also disclosed are methods of making electrochemical cells comprising the ionic liquids, and an electrochemical cell comprising an alkaline electrolyte and a hetero ionic complex additive.
专利号:US-2023407293-A1 优先权日:2021-10-27 标 题:Dna-encoded and affinity-tagged masked-warhead compounds and use thereof in assembling libraries of small molecules enabled for late-stage purification and multiplexed screening of covalent ligands 发明人:MAIANTI JUAN PABLO 权利人:MAIANTI JUAN PABLO 摘要:The present disclosure relates to DNA-encoded and affinity-tagged masked warhead installation compounds and use thereof in the synthesis of electrophilic warhead DNA-Encoded Libraries (eDEL), including substituted and unsubstituted acrylamide warheads, which can be purified from unreacted library intermediates and byproducts.
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