CAS: 3858-78-4; Butan-1-Amine Hydrochloride

相似化合物

15567-09-6 1907-65-9 541-35-5

上下游产品

N-chloro-n-butylamine N-butylamine diisopropyl N-butylphosphoramidate chloranilN-(5-methylfurfuryl)-n-butylamine N-butylacetamide n-butyl is°Cyanide N-butylpyridin-4-amine

正丁胺置于盐酸体系中,用 1,4-二氧六环,二氯甲烷 用作溶剂,化学反应 1.0H,反应生成正丁胺盐酸盐
参考文献:通过球磨直接酰胺化酯**
标题:通过球磨直接酰胺化酯**
摘要:描述了通过球磨对酯进行直接机械化学酰胺化.操作简单的程序需要一种酯,一种胺和亚化学计量的 Kotbu,并被用于制备一个包含 78 个酰胺结构的大型和多样化的库,效率适中至极好.杂芳族和杂环组分特别表明适合这种机械化学协议.这种直接合成平台已应用于活性药物成分 (Api) 和农用化学品的合成以及活性药物的克级合成,所有这些都在没有反应溶剂的情况下进行.
Doi:10.1002/anie.202106412

专利信息

专利号:US-5910594-A
优先权日:1997-02-13
标题 :Process for the manufacture of 5-cyano-4-lower alkyl-oxazoles
发明人：BEHRINGER KLAUS; BONRATH WERNER; PAULING HORST
权利人:ROCHE VITAMINS INC
摘要:A process for the manufacture of a 5-cyano-4-lower alkyl-oxazole by the dehydration of a 5-carbamoyl-4-lower alkyl-oxazole is disclosed. The reaction is carried out by dehydrating the oxazole with silicon tetrachloride in the presence of an amine in an aprotic organic solvent. 5-Carbamoyl-4-methyl-oxazole may be dehydrated by the process in accordance with the invention to obtain 5-cyano-4-methyl-oxazole, which is a valuable intermediate in the synthesis of pyridoxine.

专利号:US-4701527-A
优先权日:1983-12-05
标 题 :Synthesis of salicylamides with improved reaction kinetics and improved effective yields
发明人：KOERMER GERALD S; GUTIERREZ EDDIE N; PROROK MARYFRANCES
权利人:LEVER BROTHERS LTD
摘要:A method of synthesizing with improved reaction kinetics and improved effective yields salicylamide compounds of the formula: or wherein R1 is a substituent selected from the group consisting of -H, -COCnH2n+1 and -CnH2n+1 wherein n is an integer with a value of from 1 through to about 15, R2 is a substituent selected from the group consisting of -H, -CN, -NO2, -F, -Cl, -Br, -I, -CF3, -CBr3, -CCl3, -CI3 and R1 and R3 is an R2 substituted heterocyclic compound selected (e.g.) from the group consisting of furan, thiazole, benzothiazole and purine which comprises reacting a phenyl salicylate ester bearing an R1 substituent on the benzene ring of the salicylic acid portion thereof with an R2 substituted aniline or a heterocyclic amine NH2-R3 and with a Lowry-Bronsted acid catalyst, optionally in the presence of an inert solvent such as a halogenated or unhalogenated aromatic compound or a polyethylene glycol of average molecular weight 1000 to 6000 or mixtures thereof at a temperature of above about 150 DEG C. for about one half to about 4 hours. When the Lowry-Bronsted acid catalyst takes the form of the hydrochloride salt of the reactant aniline or heterocyclic amine the amount of the free reactant aniline or heterocyclic amine is reduced proportionately.

专利号:EP-1491540-B1
优先权日:2001-03-30
标题 :Intermediates useful for the synthesis of pyridazinone aldose reductase inhibitors

专利号:KR-20200006544-A
优先权日:2017-04-21
标 题:Process for preparing PIPERAZINE ring for the synthesis of pyrazinocarbazole (PYRAZINOCARBAZOLE) derivatives

专利号:CN-105949358-A
优先权日:2010-10-20
标题:Synthesis of Methylene Malonate Essentially Free of Impurities

专利号:ES-2274369-T3
优先权日:2001-03-30
标 题:USEFUL INTERMEDIATES FOR SYNTHESIS OF PIRIDAZINONAS INHIBIDORAS OF ALDOSA REDUCTASA.