CAS: 4858-85-9; 2,3-Dichloropyrazine

相似化合物

873-40-5 13484-50-9 14508-49-7

上下游产品

CAS号14508-49-7 2-氯吡嗪 | CAS号6863-76-9 3-氯吡嗪1-氧化物 | CAS号931-18-0 1,4-二氢吡嗪-2,3-二酮 | CAS号290-37-9 吡嗪 | CAS号2423-84-9 N,N-二氧化吡嗪 | CAS号16025-16-4 Pyrazine, 2-chl... | CAS号7732-18-5 水 | CAS号7782-50-5 氯气 | CAS号105985-17-9 3-氯吡嗪-2(1H)-酮 | CAS号40155-28-0 2-氯-3-甲氧基吡嗪 | CAS号6863-73-6 2-氨基-3-氯吡嗪 | CAS号63286-28-2 2-氯-3-肼基吡嗪 | CAS号313657-05-5 1-(3-氯-2-吡嗪)-4-甲基哌嗪 | CAS号32493-80-4 2,3-dichloro-5-... | CAS号14423-79-1 4-氨基-N-(3-氯吡嗪基)-苯磺酰胺 | CAS号1588-89-2 2,3-联苯基哌嗪 | CAS号720692-53-5 1-(3-氯吡嗪-2-基)吡咯烷-2-酮

2-氯吡嗪置于2,2,6,6-四甲基哌啶,正丁基锂,六氯乙烷体系中,用 四氢呋喃,正己烷 作为反应溶剂,化学反应 1.5H,以90%的收率获得产物2,3-二氯吡嗪
参考文献:从葡萄灰霉病菌合成吡嗪生物碱.二嗪43
标题:从葡萄灰霉病菌合成吡嗪生物碱.二嗪43
摘要:吡嗪的区域选择性金属化和交叉偶联反应提供了容易获得硼替拉嗪a和b以及硼替拉嗪a的异构体的优点,并且氯吡嗪的收率很高.
DOI:10.1021/jo0478196

专利信息

专利号:US-8846916-B2
优先权日:2009-05-11
标题:Sitagliptin synthesis
发明人：GORE VINAYAK GOVIND; GADAKAR MAHESHKUMAR; BHOSLE PRIYANKA; SHINDE SURESH
权利人:GORE VINAYAK GOVIND; GADAKAR MAHESHKUMAR; BHOSLE PRIYANKA; SHINDE SURESH; GENERICS UK LTD
摘要:The present invention relates to novel processes for the preparation of enantiomerically enriched β-amino acid derivatives such as β-amino esters useful for the synthesis of enantiomerically enriched biologically active molecules such as sitagliptin. The key step involves the resolution of the racemate with mandelic acid.

专利号:US-9574189-B2
优先权日:2005-12-01
标题:Enzymatic encoding methods for efficient synthesis of large libraries
发明人：FRANCH THOMAS; LUNDORF MIKKEL DYBRO; JACOBSEN SØREN NYBOE; OLSEN EVA KAMPMANN; ANDERSEN ANNE LEE; HOLTMANN ANETTE; HANSEN ANDERS HOLM; SØRENSEN ANDERS MALLING; GOLDBECH ANNE; DE LEON DAEN; KALDOR DITTE KIEVSMOSE; SLØK FRANK ABILDGAARD; HUSEMOEN GITTE NYSTRUP; DOLBERG JOHANNES; Jensen Kim Birkebæ; PEDERSEN LENE; NØRREGAARD-MADSEN MADS; GODSKESEN MICHAEL ANDERS; GLAD SANNE SCHRØDER; NEVE SØREN; THISTED THOMAS; KRONBORG TINE TITILOLA AKINLEMINU; SAMS CHRISTIAN KLARNER; FELDING JAKOB; FRESKGÃ…RD PER-OLA; GOULIAEV ALEX HAAHR; PEDERSEN HENRIK
权利人:FRANCH THOMAS; LUNDORF MIKKEL DYBRO; JACOBSEN SØREN NYBOE; OLSEN EVA KAMPMANN; ANDERSEN ANNE LEE; HOLTMANN ANETTE; HANSEN ANDERS HOLM; SØRENSEN ANDERS MALLING; GOLDBECH ANNE; DE LEON DAEN; KALDOR DITTE KIEVSMOSE; SLØK FRANK ABILDGAARD; HUSEMOEN GITTE NYSTRUP; DOLBERG JOHANNES; Jensen Kim Birkebæ; PEDERSEN LENE; NØRREGAARD-MADSEN MADS; GODSKESEN MICHAEL ANDERS; GLAD SANNE SCHRØDER; NEVE SØREN; THISTED THOMAS; KRONBORG TINE TITILOLA AKINLEMINU; SAMS CHRISTIAN KLARNER; FELDING JAKOB; FRESKGÃ…RD PER-OLA; GOULIAEV ALEX HAAHR; PEDERSEN HENRIK; NUEVOLUTION AS
摘要:Disclosed is a method for obtaining a bifunctional complex comprising a molecule linked to a single stranded identifier oligonucleotide, wherein a nascent bifunctional complex comprising a chemical reaction site and a priming site for enzymatic addition of a tag is a) reacted at the chemical reaction site with one or more reactants, and b) reacted enzymatically at the priming site with one or more tag(s) identifying the reactant(s).

专利号:US-2005107610-A1
优先权日:2003-11-19
标题 :Synthesis of 2-chloro-3,6-dialkyl pyrazines
发明人：RAPPATH DAVID W
权利人:PFIZER
摘要:A process for the production of 3,6-dialkyl-2,5-piperazinediones is disclosed.

专利号:US-11225655-B2
优先权日:2010-04-16
标题:Bi-functional complexes and methods for making and using such complexes
发明人：GOULIAEV ALEX HAAHR; FRANCH THOMAS; GODSKESEN MICHAEL ANDERS; JENSEN KIM BIRKEBAEK
权利人:GOULIAEV ALEX HAAHR; FRANCH THOMAS; GODSKESEN MICHAEL ANDERS; JENSEN KIM BIRKEBAEK; NUEVOLUTION AS
摘要:The present invention is directed to a method for the synthesis of a bi-functional complex comprising a molecule part and an identifier oligonucleotide part identifying the molecule part. A part of the synthesis method according to the present invention is preferably conducted in one or more organic solvents when a nascent bi-functional complex comprising an optionally protected tag or oligonucleotide identifier is linked to a solid support, and another part of the synthesis method is preferably conducted under conditions suitable for enzymatic addition of an oligonucleotide tag to a nascent bi-functional complex in solution.

专利号:WO-2008132314-A2
优先权日:2007-03-30
标题 :Method for the synthesis of cubic metal nanoparticles in the presence of two reducers

专利号:US-11702652-B2
优先权日:2005-12-01
标题:Enzymatic encoding methods for efficient synthesis of large libraries