CAS: 622-86-6; (2-Chloroethoxy)Benzene

该化合物是一种氯烷化合物,其特点是明显黄色,有明显的芳香气味.它是一个有机合成的多用途中间体,特别是在制药,农用化学品和特殊化学制品的制作方面.该化合物的活性氯乙基组能产生有效的核生殖替代反应,使其对将苯氧乙基聚醚引入目标分子具有价值.在受控条件下的稳定性确保实验室和工业环境中的可靠处理. 苯乙烯2-氯乙基乙醚通常储存在惰性大气中,以尽量减少降解. 适当的安全措施,包括通风和个人防护设备,由于其潜在的刺激性能,因此被推荐为适当的安全措施,包括通风和个人防护设备.

结构式图片

欧盟法规

REACH注册ECHA物质C&L通报REACH预注册

上下游产品

CAS号122-99-6 乙二醇苯醚 | CAS号34743-87-8 2-苯氧基乙基氯甲酸酯 | CAS号107-06-2 1,2-二氯乙烷 | CAS号108-95-2 苯酚 | CAS号56-93-9 苄基三甲基氯化铵 | CAS号67-68-5 二甲基亚砜 | CAS号104-15-4 对甲苯磺酸 | CAS号107-04-0 1-溴-2-氯乙烷 | CAS号104-66-5 1,2-二苯氧乙烷 | CAS号10561-60-1 dodecyl-dimethy... | CAS号55162-34-0 4-溴苯基 2-氯乙基醚 | CAS号37421-04-8 N-甲基-2-苯氧基乙基胺 | CAS号68047-06-3 4-羟基三苯氧胺(Z异构体) | CAS号100132-04-5 2-(2-phenoxyeth... | CAS号103628-22-4 1-[4-(2-氯乙氧基)苯基... | CAS号116057-75-1 碘昔芬 | CAS号13484-37-2 1-(2-苯氧基乙基)哌嗪 | CAS号3439-73-4 4-(2-Chloroetho...

合成工艺路线路线简述

    1,2-二苯氧基乙烷置于三氯化铝体系中,用 氯苯 作为反应溶剂,化学反应生成 2-氯苯乙醚
    参考文献:1059.由1,3-二芳氧基丙烷制备一些色度.第二部分
    标题:1059.由1,3-二芳氧基丙烷制备一些色度.第二部分
    摘要:
    DOI:10.1039/jr9650005718

    海关参考信息

    专利信息


    专利号:WO-2017080770-A1
    优先权日:2015-11-10
    标题 :Synthesis of (z)-endoxifen hydrochloride
    发明人:HEINKELE GEORG; MUERDTER THOMAS; SCHWAB MATTHIAS
    权利人:ROBERT BOSCH GES FÜR MEDIZINISCHE FORSCHUNG MBH
    摘要:The invention relates to the synthesis of tamoxifen, endoxifen and derivatives thereof. Starting from a substituted benzoic acid derivative and 2-phenoxyethyl halide, the intermediate product of general formula (I) is obtained. The compound of general formula (VI) or a salt thereof is obtained from the compound of general formula (I), via isomer purification of the compound of general formula (I) by obtaining the (Z)-isomers and reacting the (Z)-isomers with an amine of formula HNR 6 R 7 . Alternatively, the compound of general formula (I) is reacted with a compound of formula HNR 6 R 7 , and the amine thus obtained is then subjected to isomer purification, wherein the compound of general formula (VI) or a salt thereof is obtained.

    专利号:US-8912150-B2
    优先权日:2001-08-03
    标题:Ribosome structure and protein synthesis inhibitors
    发明人:STEITZ THOMAS A; MOORE PETER B; SUTCLIFFE JOYCE A; OYELERE ADEGBOYEGA K; IPPOLITO JOSEPH A
    权利人:RIB X PHARMACEUTICALS INC; UNIV YALE; MELINTA THERAPEUTICS INC
    摘要:The invention provides methods for producing high resolution crystals of ribosomes and ribosomal subunits as well as crystals produced by such methods. The invention also provides high resolution structures of ribosomal subunits either alone or in combination with protein synthesis inhibitors. The invention provides methods for identifying ribosome-related ligands and methods for designing ligands with specific ribosome-binding properties as well as ligands that may act as protein synthesis inhibitors. Thus, the methods and compositions of the invention may be used to produce ligands that are designed to specifically kill or inhibit the growth of any target organism.

    专利号:US-7385064-B1
    优先权日:2005-11-30
    标题 :Catalysts for use in enantioselective synthesis
    发明人:DAVIES HUW M L; REDDY RAVISEKHARA P
    权利人:UNIV NEW YORK STATE RES FOUND
    摘要:Disclosed are compounds having the following formula: n nin which Z 11 is selected from a substituted or unsubstituted saturated adamantyl or other polycyclic group and a substituted or unsubstituted branched acyclic group containing at least 5 carbon atoms at least one of which is a tertiary carbon; and in which Z 12 is a cyclic imide. Methods of using these compounds as chiral catalysts for carbenoid reactions and for enantioselective C—H aminations are also described.

    专利号:US-5202444-A
    优先权日:1990-11-27
    标题:Optically isomeric inositol and process for making optically active compound
    发明人:OZAKI SHOICHIRO; AKIYAMA TAKAHIKO; KAGEYAMA KUNIO; MACHIDA MORIHISA
    权利人:YOKOHAMA RUBBER CO LTD
    摘要:Optically active diols and hydroxycarboxylic acids and their esters are produced by deriving 1L-1,2:5,6-di-O-cyclohexylidene-chiro-inositol from 1L-chiro-inositol as an asymmetric source, followed by introduction of a selected class of sterically hindering and asymmetrically reactive groups into the first-mentioned compound and by subsequent reduction of the resulting compound. Seven specific inositols are also derivable from synthesis of those ultimate compounds.

    专利号:US-4269773-A
    优先权日:1976-04-27
    标 题:Fused oxazolidine compounds
    发明人:MITSURU YOSHIOKA; TERUJI TSUJI; YASUHIRO NISHITANI; WATARU NAGATA
    权利人:SHIONOGI & CO
    摘要:Compounds represented by the following formula prepared from 6-aminopenicillanic acid are key intermediates in a stereo-specific synthesis of 1-oxadethiacephalosporins, highly active antibiotics: +TR [wherein COA and COB each is carboxy or protected carboxy; COX is carboxy, protected carboxy, or a group of the formula -COCQ=N2 or -COCHQ-Z (in which Q is hydrogen, lower alkyl or aryl; and Z is hydrogen or a nucleophilic group); Hal is halogen; R is lower alkyl or aralkyl; and Y is hydrogen or acyl].

    专利号:DE-102015222031-A1
    优先权日:2015-11-10
    标题 :Synthesis of (Z) -endoxifene hydrochloride
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    主要参考文献

    参考标题:Synthesis Of Pyrido[2,3‐ B ]Indole Derivatives Via Rhodium‐catalyzed Cyclization Of Indoles And 1‐sulfonyl‐1,2,3‐triazoles
    作者:Shengguo Duan,Yuehui An,Bing Xue,Yidian Chen,Wan Zhang,Ze‐feng Xu,Chuan‐ying Li |发布日期:2020.4.27
    摘要:Acyloxy‐substituted α,β‐unsaturated Imines Generated In Situ From Triazoles Can Act As Aza‐[4 C] Synthons And Be Trapped By Indoles In A Stepwise [4 + 2] Cycloaddition Reaction, Thus Providing Rapid Access To Valuable Pyrido[2,3‐b]Indoles In High Yields. Attractive Features Of This Reaction System Include Operational Simplicity, Readily Available Substrates, Construction Of Sterically Demanding Quaternary

    合成参考文献


    摘要:Schafer, E. W., Jr., and W. A. Bowles Jr. 1985. Acute oral toxicity and repellency of 933 chemicals to house and deer mice. Archives of Environmental Contamination and Toxicology 14:111-129. https://www.aphis.usda.gov/ws/nwrc/chem-effects-db/S_schafer851.pdf
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