硝基萘置于chromium(Vi) Oxide,溶剂黄146体系中,化学反应生成 3-硝基邻苯二甲酸酐 参考文献:Bogert; Boroschek,Journal Of The American Chemical Society,1901,Vol. 23,P. 751 标题:Bogert; Boroschek,Journal Of The American Chemical Society,1901,Vol. 23,P. 751
专利号:US-2007122842-A1 优先权日:2005-11-30 标题 :Massively parallel synthesis of proteinaceous biomolecules 发明人:RAJASEKARAN JOHN J; TIWARI GUNJAN; CABEZAS EDELMIRA; FIDANZA JACQUELINE A; SUNDARARAJAN NARAYAN 权利人:RAJASEKARAN JOHN J; TIWARI GUNJAN; CABEZAS EDELMIRA; FIDANZA JACQUELINE A; SUNDARARAJAN NARAYAN 摘要:Methods for fabricating dense arrays of polymeric molecules in a highly multiplexed manner are provided using semiconductor-processing-derived lithographic methods. Advantageously, the methods are adaptable to the synthesis of a variety of polymeric compounds. For example, arrays of peptides and polymers joined by peptide bonds may be fabricated in a highly multiplexed manner.
专利号:US-2007122841-A1 优先权日:2005-11-30 标题:Massively parallel synthesis of proteinaceous biomolecules 发明人:RAJASEKARAN JOHN J; TIWARI GUNJAN; CABEZAS EDELMIRA; FIDANZA JACQUELINE A; SUNDARARAJAN NARAYAN 权利人:RAJASEKARAN JOHN J; TIWARI GUNJAN; CABEZAS EDELMIRA; FIDANZA JACQUELINE A; SUNDARARAJAN NARAYAN 摘要:Methods for fabricating dense arrays of polymeric molecules in a highly multiplexed manner are provided using semiconductor-processing-derived lithographic methods. Advantageously, the methods are adaptable to the synthesis of a variety of polymeric compounds. For example, arrays of peptides and polymers joined by peptide bonds may be fabricated in a highly multiplexed manner.
专利号:US-9499578-B2 优先权日:2005-12-29 标题 :Massively parallel synthesis of biopolymeric arrays 发明人:RAJASEKARAN JOHN J; CABEZAS EDELMIRA; FIDANZA JACQUELINE A; TIWARI GUNJAN 权利人:RAJASEKARAN JOHN J; CABEZAS EDELMIRA; FIDANZA JACQUELINE A; TIWARI GUNJAN; INTEL CORP 摘要:Methods for fabricating dense arrays of polymeric molecules in a highly multiplexed manner are provided using semiconductor-processing-derived lithographic methods. Advantageously, the methods are adaptable to the synthesis of a variety of polymeric compounds. For example, arrays of branched peptides and polymers joined by peptide bonds may be fabricated in a highly multiplexed manner.
专利号:US-4374979-A 优先权日:1981-04-27 标 题:Regiospecific synthesis of anthracyclinone compounds such as daunomycinone 发明人:MITSCHER LESTER A 权利人:UNIV KANSAS ENDOWMENT ASS 摘要:A regiospecific synthesis for anthracyclinones asymmetric is disclosed. The synthesis is based upon a regiospecific bromination of the C-7 position of the alpha -tetralone which after transposing the keto group to the beta -position and reaction with an organo-lithium compound is condensed with a phthalate ester.
专利号:US-8614086-B2 优先权日:2006-12-28 标题 :Quality control methods for the manufacture of polymer arrays 发明人:HOLT GORDON; ANTANIUS GHADEER; BARNETT BRANDON 权利人:HOLT GORDON; ANTANIUS GHADEER; BARNETT BRANDON; INTEL CORP 摘要:Described are quality control methods and devices for the reproducible manufacturing and integrity monitoring of polymers on electrochemical synthesis and detection chips. The devices and methods allow for simultaneous manufacturing and synthesis of polymers.
专利号:US-6444111-B1 优先权日:1996-07-05 标 题:Electrochemical solid phase synthesis of polymers 发明人:MONTGOMERY DONALD D 权利人:COMBIMATRIX CORP 摘要:A solid phase synthesis method for the preparation of diverse sequences of separate polymers or nucleic acid sequences using electrochemical placement of monomers of nucleic acids at a specific location on a substrate containing at least one electrode that is preferably in contact with a buffering or scavenging solution to prevent chemical crosstalk between electrodes due to diffusion of electrochemically generated reagents.
[参考文献]: Koichiro Teshima, Et Al. Analytical Method For Determination Of Allylic Isoprenols In Rat Tissues By Liquid Chromatography/tandem Mass Spectrometry Following Chemical Derivatization With 3-Nitrophtalic Anhydride. J Pharm Biomed Anal. 2008 Jul 15;47(3):560-6. [参考文献]: M Pawlowska, Et Al. Sensitive Enantiomeric Separation Of Aliphatic And Aromatic Amines Using Aromatic Anhydrides As Nonchiral Derivatizing Agents. J Chromatogr A. 1994 Apr 22;666(1-2):485-91.
合成参考文献
摘要:Kleemann, A.; Engel, J.; Kutscher, B.; Reichert, D., Pharmaceutical Substances[Online], Thieme: Stuttgart, (2014). 摘要:McKeown, N. B., Science of Synthesis, (2004) 17, 1262. 摘要:Krohn, K.; Böker, N., Science of Synthesis, (2006) 28, 375.