CAS: 6591-63-5; (S)-(6-Methoxyquinolin-4-yl)((1S,2R,4S,5R)-5-Vinylquinuclidin-2-yl)Methanol Sulfate Hydrate(2:1:2)
该化合物是一种晶状的碱性碱性碱性衍生物,通常用于制药和研究用途.作为五碘硫酸盐盐,它具有很高的纯度和稳定性,适合精确的配方.二氢酸盐形式确保了对实验室和工业使用至关重要的一致溶解性和处理特性.其主要优势在于其特性清晰的药理活动,特别是作为作为参考标准的IA类抗呼吸剂.该化合物还用于用于校准和方法鉴定的分析化学.严格的质量控制措施确保遵守药理标准,支持临床和研究环境的可靠性能.
- 英文名称(S)-(6-Methoxyquinolin-4-yl)((1S,2R,4S,5R)-5-Vinylquinuclidin-2-yl)Methanol Sulfate Hydrate(2:1:2)
- 中文名称硫酸奎尼丁二水合物
- IUPAC名称(S)-(6-methoxyquinolin-4-yl)((1S,2R,4S,5R)-5-vinylquinuclidin-2-yl)methanol hemisulfate dihydrate
- 其它别名Quinidine Sulfate (2:1) (Salt), Dihydrate [who-Ip]; Quinidini Sulfas [who-Ip Latin]; Quinidine Sulfate Hydrate; Quinidine, Sulfate (2:1) (Salt); Quinidine Sulphate Dihydrate; Quinicardine; Quinidine Sulfate [who-Ip]; Quinidine Sulfate [mart.]; J-2
- CAS编号6591-63-5
- MFCD编号:MFCD00149346
- EINECS号:678-472-8
- FDA UNII编号:J13S2394HE
- 分子式:C40H54N4O10S
- 分子量:782.96
- 产品CID: 1640126
- 产品分类原料药 → 循环系统用药 → 抗心律失常药
- 相似结构搜索
- InChIKey: ZHNFLHYOFXQIOW-AHSOWCEXSA-N
- AKYHKWQPZHDOBW-ZAXYGKDDNA-N…
- 计算化学: 氢键受体数10.0氢键供体数5.0可旋转键数4.0
物理性质
- 熔点212-214 °C (分解)(文献)
- 沸点212-214 °C (分解)
- 闪点554 °C
- PH:[α]D20 +260～+270° (c=5, dil. HCl.10min)
- PSA:192.62
- LogP:6.5216
- 折射率275 ° (C=2, 0.1mol/L HCl)
- 蒸汽压0 mmHg at 25 °C
- 溶解性Slightly Soluble In Water, Soluble In Boiling Water And In Ethanol (96 Per Cent), Practically Insoluble In Acetone.
- 敏感性光敏感
- 外观形态白色至类白色
- 储存条件在惰性气体(氮气或氩气)下 2-8°C
MSDS等安全信息
欧盟法规
C&L通报合成工艺路线路线简述
海关参考信息
- 2901210000-乙烯
2901220000-丙烯
2905121000-正丙醇
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- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:US-10925977-B2
优先权日:2006-10-05
标 题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications
发明人：YANG DAVID J; YU DONGFANG; THOMPSON ANDREW S
权利人:YANG DAVID J; YU DONGFANG; THOMPSON ANDREW S; CEIL POINT LLC; UNIV TEXAS
摘要:Novel methods of synthesis of chelator-targeting ligand conjugates, compositions comprising such conjugates, and therapeutic and diagnostic applications of such conjugates are disclosed. The compositions include chelator-targeting ligand conjugates optionally chelated to one or more metal ions. Methods of synthesizing these compositions in high purity are also presented. Also disclosed are methods of imaging, treating and diagnosing disease in a subject using these novel compositions, such as methods of imaging a tumor within a subject and methods of diagnosing myocardial ischemia.
专利号:AU-2007308022-A2
优先权日:2006-10-05
标题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications
专利号:AU-2007308022-A1
优先权日:2006-10-05
标 题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications
专利号:US-2008107598-A1
优先权日:2006-10-05
标 题:Efficient Synthesis of Chelators for Nuclear Imaging and Radiotherapy: Compositions and Applications
专利号:AU-2007308022-B2
优先权日:2006-10-05
标题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications
专利号:CA-2664826-C
优先权日:2006-10-05
标 题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications
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📌 第三方产品分析报告
合成参考文献
摘要:Journal of Pharmacology and Experimental Therapeutics., 123(269), 1958 []
参考文献:10.1016/j.bmcl.2015.09.034
摘要:Russo CM, Adhikari AA, Wallach DR, Fernandes S, Balch AN, Kerr WG, Chisholm JD. Synthesis and initial evaluation of quinoline-based inhibitors of the SH2-containing inositol 5′-phosphatase (SHIP). Bioorganic & Medicinal Chemistry Letters. 2015 Nov;25(22):5344–8. doi: 10.1016/j.bmcl.2015.09.034.
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