CAS: 107724-20-9; Methyl (4As,4Br,5Ar,6As,7R,9As,9Br,10R)-4A,6A-Dimethyl-2,4'-Dioxo-2,4,4A,4',5A,5',6,6A,8,9,9A,9B,10,11-Tetradecahydro-3H,3'H-Spiro[cyclopenta[1,2]Phenanthro[4,4A-B]Oxirene-7,2'-Furan]-10-Carboxylate

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CAS号95716-70-4 孕烯羧酸内酯 | CAS号67-56-1 甲醇 | CAS号192704-54-4 4'S(4'α),7'α-he... | CAS号124-41-4 甲醇钠 | CAS号192569-17-8 11α-羟基坎利酮 | CAS号95716-71-5 3-氟苄脒盐酸盐

依普利酮中间体a2-2置于dipotassium Hydrogenphosphate,双氧水体系中,用82%的收率获得依普利酮
参考文献:依普利酮的化学生物合成
标题:依普利酮的化学生物合成
摘要:本文将描述一种合成依普利酮的方法,该方法已上市用于治疗高血压.合成从野生山药中的 Dhea 开始,并使用微生物和化学转化的组合来构建依普利酮.
Doi:10.1055/s-2008-1032064

专利信息

专利号:US-10973847-B2
优先权日:2017-06-30
标题 :Core-to-surface polymerization for the synthesis of star polymers and uses thereof
发明人：JOHNSON JEREMIAH A; GOLDER MATTHEW R
权利人:MASSACHUSETTS INST TECHNOLOGY
摘要:Disclosed are methods, compositions, reagents, systems, and kits to prepare star polymers, as well as compositions and uses thereof. Various embodiments show that synthesis of these polymers contain low metal concentration to provide polymers for diverse biomedical applications including in vivo applications.

专利号:US-9562068-B2
优先权日:2014-10-17
标 题 :Process for the preparation of 7 α-(methoxycarbonyl)-3-OXO-17alpha-pregn-4,9(11)-dien-21,17-carbolactone, a useful intermediate for the synthesis of molecules with pharmacological activity
发明人：LENNA ROBERTO; DI BRISCO RICCARDO; BARBIERI FRANCESCO
权利人:IND CHIMICA SRL; IND CHIMICA SRL
摘要:An improved process for the preparation of intermediate (V) through the elimination of a molecule of water from intermediate (IV) is described. n nIntermediate (V) is a key molecule for the synthesis of eplerenone, a synthetic steroid with pharmacological activity used in the treatment of chronic pathological conditions, including hypertension.

专利号:US-8367394-B2
优先权日:2007-07-04
标题:Process for the synthesis of 9α-hydroxy-steroids
发明人：OLASZ KATALIN; TEGDES ANIKO; GANCSOS VALERIA; HANTOS GABOR; KOENCZOEL KALMAN; BALOGH GABOR; ERDELYI SANDOR
权利人:RICHTER GEDEON NYRT; OLASZ KATALIN; TEGDES ANIKO; GANCSOS VALERIA; HANTOS GABOR; KOENCZOEL KALMAN; BALOGH GABOR; ERDELYI SANDOR
摘要:The present invention relates to a novel selective synthesis of 9α-hydroxy-steroid derivatives of the general formula (I) (I)—wherein the meaning of -A-A′- is —CH 2 —CH 2 — or —CHâ•?CH— group—by the bioconversion of compounds of the general formula (II) (II) wherein the meaning of -A-A′- is —CH 2 —CH 2 — or —CHâ•?CH— group—by using Nocardia farcinica bacterium strain, deposition number of which is NCAIM (P)—B 001342, as hydroxylating microorganism in the bioconversion.

专利号:US-2008287407-A1
优先权日:2003-12-10
标题 :Nitric Oxide Releasing Pyruvate Compounds, Compositions and Methods of Use
发明人：GARVEY DAVID S; FANG XINQIN; KHANAPURE SUBHASH P; RANATUNGA RAMANI R; WEY SHIOW-JYI
权利人:NITROMED INC
摘要:The invention describes novel nitrosated and/or nitrosylated pyruvate compounds and pharmaceutically acceptable salts thereof, and novel compositions comprising at least one nitrosated and/or nitrosylated pyruvate compound, and, optionally, at least one compound that donates, transfers or releases nitric oxide, stimulates endogenous synthesis of nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor or is a substrate for nitric oxide synthase, and/or at least one therapeutic agent. The invention also provides novel compositions comprising at least one pyruvate compound and at least one compound that donates, transfers or releases nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor, stimulates endogenous synthesis of nitric oxide or is a substrate for nitric oxide synthase and/or at least one therapeutic agent. The invention also provides novel kits comprising at least one pyruvate compound, that is optionally nitrosated and/or nitrosylated, and, optionally, at least one nitric oxide donor and/or at least one therapeutic agent. The invention also provides methods for treating diseases resulting from oxidative stress, diabetes, reperfusion injury following ischemia, preservation of tissues, organs, organ parts and/or limbs.

专利号:US-2024368164-A1
优先权日:2021-04-28
标 题 :Purine nucleosides, their intermediates, and methods of preparation thereof
发明人：RAVI RAMA SURESH; JACOBSON KENNETH A; POE RUSSELL BIRCH
权利人:ASTROCYLE PHARMACEUTICALS INC; US HEALTH
摘要:The present invention provides purine nucleoside analog compounds and methods of use thereof for treatment of certain injuries, disorders and conditions, for example brain injuries such as stroke or traumatic brain injuries. The present invention further provides methods of synthesizing such compounds, and intermediates useful in the synthesis of such compounds.

专利号:US-6610844-B2
优先权日:1996-12-11
标题:Processes for preparation of 9,11-epoxy steroids and intermediates useful therein
发明人：NG JOHN S; LIU CHIN; ANDERSON DENNIS K; LAWSON JON P; WIECZOREK JOSEPH; KUNDA SASTRY A; LETENDRE LEO J; POZZO MARK J; SING YUEN-LUNG L; WANG PING T; YONAN EDWARD E; WEIER RICHARD M; KOWAR THOMAS R; BAEZ JULIO A; ERB BERNHARD
权利人:SEARLE & CO
摘要:Multiple novel reaction schemes, novel process steps and novel intermediates are provided for the synthesis of epoxymexrenone and other compounds of Formula Iwherein-A-A- represents the group -CHR4-CHR5- or -CR4=CR5-;R3, R4 and R5 are independently selected from the group consisting of hydrogen, halo, hydroxy, lower alkyl, lower alkoxy, hydroxyalkyl, alkoxyalkyl, hydroxycarbonyl, cyano and aryloxy;R1 represents an alpha-oriented lower alkoxycarbonyl or hydroxyalkyl radical;-B-B- represents the group -CHR6-CHR7- or an alpha- or beta-oriented group:where R6 and R7 are independently selected from the group consisting of hydrogen, halo, lower alkoxy, acyl, hydroxyalkyl, alkoxyalkyl, hydroxycarbonyl, alkyl, alkoxycarbonyl, acyloxyalkyl, cyano and aryloxy; andR8 and R9 are independently selected from the group consisting of hydrogen, hydroxy, halo, lower alkoxy, acyl, hydroxyalkyl, alkoxyalkyl, hydroxycarbonylalkyl, alkoxycarbonylalkyl, alkoxycarbonyl, acyloxyalkyl, cyano and aryloxy, or R8 and R9 together comprise a carbocyclic or heterocyclic ring structure, or R8 or R9 together with R6 or comprise a carbocyclic or heterocyclic ring structure fused to the pentacyclic D ring.