CAS: 111721-75-6; 2-Bromo-3-Fluoroaniline

该化合物是一种卤化阴性衍生物,配有分子式C6H5BFF,该化合物是有机合成的多用途中间体,特别是在制备药品,农用化学品和特殊化学品方面.芳香环上存在溴和氟替代成分,这增强了其回活动性,使得能够在特定位置有选择性地发挥功能.其明确的结构和高纯度使得它适合交叉反应,如铃木或Buchwald-Hartwig的配对,便利复杂分子的制造.该化合物在标准条件下的稳定可以确保可靠的处理和储存.它通常用于需要精确卤化建筑块的研究和工业应用.

英文名称2-Bromo-3-Fluoroaniline
中文名称2-溴-3-氟苯胺
IUPAC名称2-bromo-3-fluoroaniline
其它别名2-溴-3-氟苯胺(Cas号:111721-75-6); Bromo-3-Fluoroaniline
CAS编号111721-75-6
MFCD编号:MFCD07369915
EINECS号:676-172-1
分子式:C6H5BrFN
分子量:190.01
产品CID: 151960
产品分类有机原料→分子砌块→芳环类化合物→苯类化合物

相似结构搜索
InChIKey: XZRSXRUYZXBTGD-UHFFFAOYSA-N
InChI=1S/C6H5BrFN/c7-6-4(8)2-1-3-5(6)9/h1-3H,9H2…
计算化学: 氢键受体数1.0氢键供体数1可旋转键数0

相似化合物

59255-94-6 500357-40-4 1253889-53-0

MSDS等安全信息

GHS象形图
GHS符号GHS07;
注释: Exclamation mark
危险类别急性毒性类别4(吸入)
急性毒性类别4(经皮)
急性毒性类别4(经口)
特定目标器官毒性 - 单次接触类别3
皮肤腐蚀/刺激类别2
严重眼刺激类别2
警示词Warning(警告)
危险描述H332 |吸入有害.
H312 |皮肤接触有害.
H302 |吞咽有害.
H335 |可能引起呼吸道刺激.
H315 |造成皮肤刺激.
H319 |造成严重眼刺激.
防范说明P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
危险等级6.1
UN编号2811
危险品标志Xi,Xn
风险等级Harmful/Irritant
安全声明9-26-36/37-60
危险类别码22-36-36/37/38-20/21/22

欧盟法规

ECHA物质C&L通报

上下游产品

合成工艺路线路线简述

合成目标产物 2-Bromo-3-Fluoroaniline 主要起始原料 2-Bromo-3-Fluoronitrobenzene
(文献来源)合成步骤主要原料 2-Bromo-3-Fluoronitrobenzene

2-溴-3-氟苯酚置于盐酸,Sodium Hydroxide体系中,用乙醇,水,N,N-二甲基甲酰胺用作溶剂,化学反应 5.0H,反应生成2-溴-3-氟苯胺
参考文献:2,3-二卤代苯胺的合成方法.4-功能化-1 H-吲哚的有用前体
标题:2,3-二卤代苯胺的合成方法.4-功能化-1 H-吲哚的有用前体
摘要:已经证明2,3-二卤代苯胺是用于合成4-卤代-1 H-吲哚的有用的起始原料.所制备的卤代吲哚的随后或原位官能化使得能够以非常好的总收率获得各种2,4-或2,3,4-区域选择性官能化的吲哚.由于在文献中没有描述制备2,3-二卤代苯胺的有效合成途径,因此现在提出了制备这些1,2,3-官能化的芳族前体的不同方法.最一般的涉及从相应的2,3-二卤代苯酚的smiles重排,并允许以直接且合成上有用的方式制备2,3-二卤代苯胺.
Doi:10.1021/jo200406F

专利信息

专利号:US-11873305-B2
优先权日:2020-06-30
标题 :Processes for synthesis of substituted indole intermediates for the synthesis of serd compounds
发明人：ZHANG HAIMING; XU JIE; WUITSCHIK GEORG; ANGELAUD REMY; HEROLD SEBASTIAN; STUTZ ALFRED; BRUETSCH TOBIAS; BURKHARD JOHANNES
权利人:GENENTECH INC; HOFFMANN LA ROCHE
摘要:Provided herein are processes for the preparation of indolyl intermediates using Wenker Synthesis for the total synthesis of SERD compounds useful in the treatment of cancer.

专利号:US-11401277-B2
优先权日:2017-11-29
标题 :Anti-bacterial heterocyclic compounds and their synthesis
发明人：PEER MOHAMED SHAHUL HAMEED; BHARATHAM NAGAKUMAR; KATAGIHALLIMATH NAINESH; SHARMA SREEVALLI; NANDISHAIAH RADHA; RAMACHANDRAN VASANTHI
权利人:BUGWORKS RES INC
摘要:The invention relates to compounds of Formula I and Formula (B) along with their stereoisomers, pharmaceutically acceptable salts, complexes, hydrates, solvates, tautomers, polymorphs, racemic mixtures, optically active forms, and pharmaceutically active derivatives thereof. These compounds are useful for killing or inhibiting the growth of a microorganism selected from the group consisting of bacteria, virus, fungi, and protozoa.

专利号:US-10912780-B2
优先权日:2017-06-08
标题:Heterocyclic compounds useful as anti-bacterial agents and method for production thereof
发明人：PEER MOHAMED SHAHUL HAMEED; BHARATHAM NAGAKUMAR; KATAGIHALLIMATH NAINESH; SHARMA SREEVALLI; NANDISHAIAH RADHA; RAMACHANDRAN VASANTHI; VENKATARAMAN BALASUBRAMANIAN
权利人:BUGWORKS RES INC
摘要:The present disclosure relates to compounds of Formula I, or their stereoisomers, pharmaceutically acceptable salts, complexes, hydrates, solvates, tautomers, polymorphs, racemic mixtures, optically active forms and pharmaceutically active derivatives thereof, and pharmaceutical compositions containing them as the active ingredient which can be used as medicaments. The aforementioned substances can also be used in the manufacture of medicaments for treatment, prevention or suppression of diseases, and conditions mediated by microbes. The present disclosure also relates to the synthesis and characterization of aforementioned substances.