L-酪氨酸,氯乙酰氯置于sodium Hydroxide体系中,用 乙醚,水 用作溶剂,化学反应 0.33H,反应生成氯乙酰基-L-酪氨酸 参考文献:Pcl3-Mediated Synthesis Of Green/cyan Fluorescent Protein Chromophores Using Amino Acids 标题:Pcl3-Mediated Synthesis Of Green/cyan Fluorescent Protein Chromophores Using Amino Acids 摘要:一种高效合成绿色和青色荧光蛋白色素的方法已成功开发,使用的原料包括l-酪氨酸和l-色氨酸,并利用pcl3进行反应. Doi:10.1039/c5Nj03144C
专利号:FR-2845389-A1 优先权日:2002-10-04 标 题 :PROCESS FOR THE SYNTHESIS OF PEPTIDES COMPRISING AT LEAST ONE GLYCIN MOLECULE
专利号:DE-60316973-T2 优先权日:2002-10-04 标题 :PROCESS FOR SYNTHESIS OF PEPTIDES CONTAINING AT LEAST ONE GLYCIN MOLECULE
专利号:US-5340734-A 优先权日:1992-11-25 标 题 :Method for making stable, extracellular tyrosinase and synthesis of polyphenolic polymers therefrom
专利号:CA-2149764-C 优先权日:1992-11-25 标 题 :Method for making stable, extracellular tyrosinase and synthesis of polyphenolic polymers therefrom
专利号:US-9783800-B2 优先权日:2014-02-03 标 题:Method for producing peptides having azole-derived skeleton 发明人:SUGA HIROAKI; GOTO YUKI; KATO YASUHARU 权利人:UNIV TOKYO 摘要:Object of the present invention is to develop an artificial synthesis system of various peptides having an azole derivative structure and develop a library of such peptides. The present invention provides a method of producing a peptide having, in the backbone thereof, an azole derivative structure comprising the step of: synthesizing a substrate peptide of an azoline structure introducing enzyme having, in the modified region thereof, at least any one of the following amino acids, n n[in any of the compounds,n X 1 represents a group selected from the group consisting of SH, OH, NH 2 , SR 1 , OR 1 , NHR 1 , and N 3 (R 1 represents a protecting group), X 2 represents an easily eliminable group; and X 3 represents hydrogen or a substituted or unsubstituted alkyl or aryl group having from 1 to 10 carbon atoms]; reacting the substrate peptide with an azoline structure introducing enzyme to obtain a peptide having an azoline derivative structure; and converting the azoline derivative structure of the resulting peptide into an azole derivative structure by inducing an HX 2 elimination reaction of X 2 group.
专利号:CN-102976967-A 优先权日:2012-11-13 标题:Synthesis and Study of an Intermediate of Glycyl-L-Tyrosine
参考文献:10.1038/s41570-019-0159-2 摘要:Sohrabi C, Foster A, Tavassoli A. Methods for generating and screening libraries of genetically encoded cyclic peptides in drug discovery. Nat Rev Chem. 2020 Feb;4(2):90–101. doi: 10.1038/s41570-019-0159-2.