CAS: 138-41-0; 4-Sulfamoylbenzoic Acid

上下游产品

CAS号70-55-3 对甲苯磺酰胺 | CAS号10130-89-9 4-氯磺酰基苯甲酸 | CAS号17202-49-2 4-羧基苯磺酰叠氮 | CAS号701-34-8 4-溴苯磺酰胺 | CAS号657-84-1 对甲苯磺酸钠 | CAS号3240-35-5 4-甲酰基苯磺酰胺 | CAS号1135-00-8 4-正丁基苯磺胺 | CAS号3119-02-6 对氰基苯磺酰胺 | CAS号1146-43-6 N-(4-羟基苯基)-4-甲基苯磺酰胺 | CAS号834-04-8 4-sulfamoyl-cin... | CAS号35264-29-0 4-肼基羰基苯磺酰胺 | CAS号57-66-9 丙磺舒 | CAS号3240-35-5 4-甲酰基苯磺酰胺 | CAS号49584-26-1 4-氰基苯磺酰氯 | CAS号80-13-7 哈拉宗 | CAS号106145-03-3 4-(chlorosulfam... | CAS号22808-73-7 4-磺酰胺苯甲酸甲酯 | CAS号103204-31-5 prop-2-enyl 4-s... | CAS号1206-37-7 4-二甲基磺酰基苯甲酸 | CAS号3119-02-6 对氰基苯磺酰胺

对甲苯磺酰胺置于potassium Permanganate体系中,用 水 用作溶剂,化学反应生成对羧基苯磺酰胺
参考文献:具有苯并磺酰胺的咪唑并噻二唑和噻唑三唑支架作为有效的与肿瘤相关的人碳酸酐酶ix和xii抑制剂
标题:具有苯并磺酰胺的咪唑并噻二唑和噻唑三唑支架作为有效的与肿瘤相关的人碳酸酐酶ix和xii抑制剂
摘要:为了研究两种支架对两种选定的人碳酸酐酶同工型(hca I,Ii,Ix)的抑制潜力,合成了两个系列的20种新颖的杂环化合物,分别是咪唑并噻二唑(3A-3J)和噻唑三唑(4A-4J),带有苯磺酰胺部分. &xii).相对于人同工型hca I,化合物3J,4A-4C和4J表现出 比标准药物乙酰唑胺(aza)更好的抑制潜力(k I <100 Nm).针对hca Ii,除3A外,所有化合物均显示出中度抑制作用与aza相比,显示出近两倍的轮廓.对于hca Ix,所有化合物均显示出比aza中等的抑制潜能,而对于hca Xii,化合物3A-3C与aza相比显示出更好的抑制潜能.
Doi:10.1016/j.Bmc.2016.12.047

专利信息

专利号:US-11186678-B2
优先权日:2018-11-30
标 题 :Radical cascade-enabled synthesis of precision polymers with complex main-chain structures
发明人：NIU JIA; HUANG HANCHU; WANG WENQI
权利人:TRUSTEES BOSTON COLLEGE
摘要:Radical cascade reactions enabling sequence-controlled ring-closing polymerization and ring-opening polymerization for the controlled synthesis of polymers with complex main-chain structures are provided. Facile syntheses leading to low-strain macrocyclic monomers consisting of the ring-opening triggers and extended main-chain structures are also provided. The present disclosure further provides methods for excellent control over polymer molecular weights and molecular weight distributions and high chain-end fidelity allows for the preparation of polymeric systems with well-defined architectures. Further provided are the general nature of the radical cascade-triggered transformations in polymer chemistry, and its application to the synthesis of polymers with diverse main-chain structural motifs with tailored functions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.

专利号:US-4142050-A
优先权日:1975-11-06
标题 :Salts of 1,3-bis(β-ethylhexyl)-5-amino-5-methyl-hexahydropyrimidine
发明人：KUNZ WILHELM; POSSELT KLAUS
权利人:DOLL GMBH
摘要:Novel salts of 1,3-bis-( beta -ethylhexyl)-5-amino-5-methyl-hexahydropyrimidine (hexetidine) with substituted benzoic acids and processes of preparing these salts are described. These novel salts have useful bacteriostatic activity and show stability in storage. The invention accordingly comprises compositions containing the novel salts and having bacteriostatic activity. The salts are additionally useful for the purification of hexetidine contained in raw mixtures obtained from the synthesis of this compound.

专利号:US-6583318-B2
优先权日:2001-05-17
标 题:Method for synthesis of α-sulfonamido amide, carboxylic acid and hydroxamic acid derivatives
发明人：CAMPIAN EUGENE; LOU BOLIANG; MJALLI ADNAN M M
权利人:ADVANCED SYNTECH LLC
摘要:A method of synthesizing alpha-sulfonamido amide, carboxylic acid or hydroxamic acid derivatives comprising providing a set of polymer-bound reactant(s) (sulfonamide, aldehyde or ketone, isocyanide or acid) to react with three sets of the other three reactants to form an array of polymer-bound alpha-sulfonamido amide-type intermediates and use of such intermediates for the preparation of combinatorial libraries.

专利号:US-10370409-B2
优先权日:2011-10-25
标题 :Synthesis of libraries of peptide tertiary amides
发明人：KODADEK THOMAS; GAO YU
权利人:SCRIPPS RESEARCH INST
摘要:The present disclosure is directed to a novel class of peptide-like oligomers called peptide tertiary amides (PTAs) and a combinatorial library of PTAs along with synthetic routes for the preparation of large combinatorial libraries of these compounds. The peptide tertiary amides provide an exceptional source of high affinity and selective protein ligands that are useful as tools for biological research and as drug leads, among others.

专利号:US-7262023-B2
优先权日:2002-07-24
标题:Microbiological process for the production of 7-substituted 11-hydroxy steroids, 7,17-substituted 11-Halogen steroids and uses thereof
发明人：ZORN LUDWIG; BOHLMANN ROLF; GALLUS NORBERT; KUENZER HERMANN; MUHN HANS-PETER; NUBBEMEYER REINHARD
权利人:BAYER SCHERING PHARMA AG
摘要:A novel method of synthesis for the manufacture of upstream products for the production of compounds with general formulas 8, 10, and 12 is described. In this synthesis, compounds with general formula 4,B are produced in a microbiological reaction. The meanings of R 7 , R 10 , R 11 , R 13 , R 17 and R 17′ as well as of the grouping U—V—W—X—Y—Z are indicated in the claims

专利号:US-2003013910-A1
优先权日:2001-05-17
标 题:Method for synthesis of alpha-sulfonamido amide, carboxylic acid and hydroxamic acid derivatives