CAS: 1429334-00-8; (S)-N-((2-Oxo-3-(4-(3-Oxomorpholino)Phenyl)Oxazolidin-5-yl)Methyl)Acetamide

英文名称(S)-N-((2-Oxo-3-(4-(3-Oxomorpholino)Phenyl)Oxazolidin-5-yl)Methyl)Acetamide
中文名称利伐沙班杂质
IUPAC名称(S)-N-((2-oxo-3-(4-(3-oxomorpholino)phenyl)oxazolidin-5-yl)methyl)acetamide
其它别名Acetamide, N-[[(5S)-2-Oxo-3-[4-(3-Oxo-4-Morpholinyl)Phenyl]-5-Oxazolidinyl]Methyl]-; (S)-N-((2-Oxo-3-(4-(3-Oxomorpholino)Phenyl)Oxazolidin-5-yl)Methyl)Acetamide; N-[[(5S)-2-Oxo-3-[4-(3-Oxo-4-Morpholinyl)Phenyl]-5-Oxazolidinyl]Methyl]-Acetamide; Rivaroxaban Acetamide Impurity; (S)-N-[{3-(4-(3-Oxomorpholin-4-yl)Phenyl)-2-Oxo-1,3-Oxazolidin-5-Yl}Methyl]Acetamide; Rivaroxaban B; Rivaroxaban Impurity 1/(S)-N-[{3-(4-(3-Oxomorpholin-4-yl)Phenyl)-2-Oxo-1,3-Oxazolidin-5-Yl}Methyl]Acetamide; Rivaroxaban-1
CAS编号1429334-00-8
MFCD编号:MFCD28347521
FDA UNII编号:QWF3XH3UKZ
分子式:C16H19N3O5
分子量:333.34
产品CID: 656726
产品分类分析化学 → 标准品 → 药典标准品和杂质标准品

相似结构搜索
InChIKey: ZINXMVCVGXRHDV-AWEZNQCLSA-N
InChI=1S/C16H19N3O5/c1-11(20)17-8-14-9-19(16(22)24-14)13-4-2-12(3-5-13)18-6-7-23-10-15(18)21/h2-5,14H,6-10H2,1H3,(H,17,20)/t14-/m0/s1…
计算化学: 氢键受体数5.0氢键供体数1.0可旋转键数4.0

MSDS等安全信息

警示词Danger
危险描述H318-H411-
防范说明P280-P305+P351+P338+P310-
UN编号3077
安全声明CAUT
WGK Germany3

上下游产品

N-[(2S)-2-acetoxy-3-chloropropyl]acetamide 4-(4-aminophenyl)morpholin-3-one N-[(2S)oxiranylmethyl]acetamide N-[(2R)-2-hydroxy-3-{[4-(3-oxomorpholin-4-yl)phenyl]amino}propyl]acetamide 4-[4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl]morpholine-3-one

合成工艺路线路线简述

4-[4-[(5S)-5-(氨基甲基)-2-氧代-3-恶唑烷基]苯基]-3-吗啉酮盐酸盐置于potassium Carbonate,三乙胺体系中,用四氢呋喃,水用作溶剂,化学反应 4.0H,反应生成利伐沙班杂质4
参考文献:一种利伐沙班的有关物质f,G的合成方法
标题:一种利伐沙班的有关物质f,G的合成方法
摘要:本发明提出了一种利伐沙班的有关物质f,G的合成方法.本发明提供的一种利伐沙班的有关物质f,G的合成方法收率高,易于实现工业化生产和技术转换.

海关参考信息

2905122000-异丙醇
2909110000-乙醚
2912110000-甲醛
2912120000-乙醛
💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
详情请参考：📖 海关编码查询和海关进出口税则

专利信息

专利号:WO-2013046211-A1
优先权日:2011-09-27
标题 :Processes for the preparation of 5-chloro-n-({(5s)-2-oxo-3-[4-(3-oxo-4-morpholinyl) phenyl]-1,3-oxazolidin-5-yl}methyl)-2-thiophene-carboxamide and intermediates thereof
发明人：MOHAN RAO DODDA; KRISHNA REDDY PINGILI; VENKAT REDDY BUTHUKURI
权利人:SYMED LABS LTD; MOHAN RAO DODDA; KRISHNA REDDY PINGILI; VENKAT REDDY BUTHUKURI
摘要:TThe present invention provides processes for the preparation of 5-chloro-N-({(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)phenyl]-1,3-oxazolidin-5-yl}methyl)-2-thiophene-carboxamide (I) and intermediates thereof. Also provides novel intermediates and their use in the synthesis of oxazolidine derivatives.